The atypical CDK activator Spy1 regulates the intrinsic DNA damage response and is dependent upon p53 to inhibit apoptosis

Cell Cycle

Volumn 8, Issue 1, 2009, Pages 66-75

  McAndrew, Christopher W ^a   Gastwirt, Randy F ^a   Donoghue, Daniel J ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Cyclin; DNA damage; Mutagenesis; p53; Repair; Speedy ringo; Tumorigenesis

Indexed keywords

CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE ACTIVATING KINASE; CYCLIN E; HISTONE H2AX; PROTEIN P21; PROTEIN P53; PYRIMIDINE DIMER; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SPY1; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; SPDYA PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; BREAST CARCINOMA; CARCINOGENESIS; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL STRAIN HCT116; CONTROLLED STUDY; DNA DAMAGE; EXCISION REPAIR; HUMAN; HUMAN CELL; OSTEOSARCOMA CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; BIOLOGICAL MODEL; COMET ASSAY; DNA REPAIR; GENETICS; METABOLISM; MUTATION; RADIATION EXPOSURE; TUMOR CELL LINE; ULTRAVIOLET RADIATION;

APOPTOSIS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; COMET ASSAY; CYCLIN E; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; DNA DAMAGE; DNA REPAIR; HUMANS; MODELS, BIOLOGICAL; MUTATION; PYRIMIDINE DIMERS; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 60749120565     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.1.7451     Document Type: Article

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