Molecular Mechanism of the Enterococcal Aminoglycoside 6′ -N-Acetyltransferase′: Role of GNAT-Conserved Residues in the Chemistry of Antibiotic Inactivation

Biochemistry

Volumn 43, Issue 2, 2004, Pages 446-454

  Draker, Kari Ann ^a   Wright, Gerard D ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; CATALYSIS; ENZYMES; MUTAGENESIS; PH EFFECTS; PROTEINS; VISCOSITY;

MUTATIONS;

MOLECULAR DYNAMICS;

ACETYL COENZYME A; ACYLTRANSFERASE; AMIDE; AMIKACIN; AMINO ACID; AMINOGLYCOSIDE ANTIBIOTIC AGENT; GCN5 RELATED N ACETYLTRANSFERASE; GLUTAMINE; HISTIDINE; KANAMYCIN A; LEUCINE; MUTANT PROTEIN; NEAMINE; NEOMYCIN; RIBOSTAMYCIN; SOLVENT; TOBRAMYCIN; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; CATALYSIS; CHEMISTRY; CHROMOSOME; CONTROLLED STUDY; DRUG ACETYLATION; ENTEROCOCCUS FAECIUM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME MECHANISM; GENETIC CONSERVATION; GRAM POSITIVE BACTERIUM; MOLECULAR DYNAMICS; NONHUMAN; PH; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTON TRANSPORT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STEADY STATE; VISCOSITY;

ACETYLTRANSFERASES; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; CONSERVED SEQUENCE; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS FAECIUM; ENZYME ACTIVATION; GLUTAMIC ACID; HISTIDINE; HISTONE ACETYLTRANSFERASES; HYDROGEN-ION CONCENTRATION; KINETICS; LEUCINE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; TYROSINE;

BACTERIA (MICROORGANISMS); ENTEROCOCCUS; ENTEROCOCCUS FAECIUM; POSIBACTERIA;

EID: 0347093476     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035667n     Document Type: Article

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