Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 662, Issue 1-2, 2009, Pages 10-15

  Xiong, Xing Dong ^a   Qiu, Fu En ^a   Fang, Jian Hong ^a   Shen, Yi ^b   Liang, Chun ^b   Jiang, Wenqi ^c   Zhuang, Shi Mei ^a,c  

^a SUN YAT SEN UNIVERSITY   (China)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^c SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

Cdc6; Diffuse large B cell lymphoma; Hepatocellular carcinoma; Non Hodgkin lymphoma; Risk; Single nucleotide polymorphism

Indexed keywords

CASPASE; CELL CYCLE PROTEIN 6; ETOPOSIDE; MESSENGER RNA;

ADULT; APOPTOSIS; ARTICLE; B CELL LYMPHOMA; CANCER RISK; CANCER SUSCEPTIBILITY; FEMALE; GENE STRUCTURE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; LARGE CELL LYMPHOMA; LIVER CELL CARCINOMA; LOGISTIC REGRESSION ANALYSIS; MALE; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; PROTEIN FUNCTION;

ADULT; AGED; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; CELL CYCLE PROTEINS; ETOPOSIDE; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIVER NEOPLASMS; LYMPHOMA, NON-HODGKIN; MALE; MIDDLE AGED; NUCLEAR PROTEINS; NUCLEIC ACID CONFORMATION; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER;

EID: 60749100323     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2008.11.014     Document Type: Article

References (24)

1. Cocker J.H., Piatti S., Santocanale C., Nasmyth K., and Diffley J.F. An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature 379 (1996) 180-182
2. Speck C., and Stillman B. Cdc6 ATPase activity regulates ORC-Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication. J. Biol. Chem. 282 (2007) 11705-11714
3. Williams R.S., Shohet R.V., and Stillman B. A human protein related to yeast Cdc6p. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 142-147
4. Yan Z., DeGregori J., Shohet R., Leone G., Stillman B., Nevins J.R., and Williams R.S. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 3603-3608
5. Clay-Farrace L., Pelizon C., Santamaria D., Pines J., and Laskey R.A. Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1. EMBO J. 22 (2003) 704-712
6. Lau E., Zhu C., Abraham R.T., and Jiang W. The functional role of Cdc6 in S-G2/M in mammalian cells. EMBO Rep. 7 (2006) 425-430
7. Oehlmann M., Score A.J., and Blow J.J. The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation. J. Cell Biol. 165 (2004) 181-190
8. Feng D., Tu Z., Wu W., and Liang C. Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells. Cancer Res. 63 (2003) 7356-7364
9. Pelizon C., d'Adda di Fagagna F., Farrace L., and Laskey R.A. Human replication protein Cdc6 is selectively cleaved by caspase 3 during apoptosis. EMBO Rep. 3 (2002) 780-784
10. Yim H., Hwang I.S., Choi J.S., Chun K.H., Jin Y.H., Ham Y.M., Lee K.Y., and Lee S.K. Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells. J. Cell Biol. 174 (2006) 77-88
11. Yim H., Jin Y.H., Park B.D., Choi H.J., and Lee S.K. Caspase-3-mediated cleavage of Cdc6 induces nuclear localization of p49-truncated Cdc6 and apoptosis. Mol. Biol. Cell 14 (2003) 4250-4259
12. Williams G.H., Romanowski P., Morris L., Madine M., Mills A.D., Stoeber K., Marr J., Laskey R.A., and Coleman N. Improved cervical smear assessment using antibodies against proteins that regulate DNA replication. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 14932-14937
13. Murphy N., Ring M., Heffron C.C., King B., Killalea A.G., Hughes C., Martin C.M., McGuinness E., Sheils O., and O'Leary J.J. p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer. J. Clin. Pathol. 58 (2005) 525-534
14. Karakaidos P., Taraviras S., Vassiliou L.V., Zacharatos P., Kastrinakis N.G., Kougiou D., Kouloukoussa M., Nishitani H., Papavassiliou A.G., Lygerou Z., and Gorgoulis V.G. Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability-evidence of E2F-1 transcriptional control over hCdt1. Am. J. Pathol. 165 (2004) 1351-1365
15. Borlado L.R., and Mendez J. CDC6: from DNA replication to cell cycle checkpoints and oncogenesis. Carcinogenesis 29 (2008) 237-243
16. Gonzalez S., Klatt P., Delgado S., Conde E., Lopez-Rios F., Sanchez-Cespedes M., Mendez J., Antequera F., and Serrano M. Oncogenic activity of Cdc6 through repression of the INK4/ARF locus. Nature 440 (2006) 702-706
17. Liontos M., Koutsami M., Sideridou M., Evangelou K., Kletsas D., Levy B., Kotsinas A., Nahum O., Zoumpourlis V., Kouloukoussa M., Lygerou Z., Taraviras S., Kittas C., Bartkova J., Papavassiliou A.G., Bartek J., Halazonetis T.D., and Gorgoulis V.G. Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Res. 67 (2007) 10899-10909
18. Frey U.H., Alakus H., Wohlschlaeger J., Schmitz K.J., Winde G., van Calker H.G., Jockel K.H., Siffert W., and Schmid K.W. GNAS1 T393C polymorphism and survival in patients with sporadic colorectal cancer. Clin. Cancer Res. 11 (2005) 5071-5077
19. Wolfe K.J., Wickliffe J.K., Hill C.E., Paolini M., Ammenheuser M.M., and Abdel-Rahman S.Z. Single nucleotide polymorphisms of the DNA repair gene XPD/ERCC2 alter mRNA expression. Pharmacogenet. Genomics 17 (2007) 897-905
20. Nackley A.G., Shabalina S.A., Tchivileva I.E., Satterfield K., Korchynskyi O., Makarov S.S., Maixner W., and Diatchenko L. Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. Science 314 (2006) 1930-1933
21. Turner J.J., Hughes A.M., Kricker A., Milliken S., Grulich A., Kaldor J., and Armstrong B. WHO non-Hodgkin's lymphoma classification by criterion-based report review followed by targeted pathology review: an effective strategy for epidemiology studies. Cancer Epidemiol. Biomarkers Prev. 14 (2005) 2213-2219
22. Zuker M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res. 31 (2003) 3406-3415
23. Vaziri C., Saxena S., Jeon Y., Lee C., Murata K., Machida Y., Wagle N., Hwang D.S., and Dutta A. A p53-dependent checkpoint pathway prevents rereplication. Mol. Cell 11 (2003) 997-1008
24. Gonzalez M.A., Tachibana K.E., Laskey R.A., and Coleman N. Control of DNA replication and its potential clinical exploitation. Nat. Rev. Cancer 5 (2005) 135-141