Enzyme induction and cytotoxicity in human hepatocytes by chlorpyrifos and N,N-diethyl-m-toluamide (DEET)

Drug Metabolism and Drug Interactions

Volumn 23, Issue 3-4, 2008, Pages 237-260

  Das, Parikshit C ^a   Cao, Yan ^a   Rose, Randy L ^a   Cherrington, Nathan ^b   Hodgson, Ernest ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Chlorpyrifos; CYP isoforms; Cytotoxicity; DEET; Human hepatocytes

Indexed keywords

ADENYLATE KINASE; CASPASE 3; CASPASE 7; CHLORPYRIFOS; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 3A4; DIETHYLTOLUAMIDE; MESSENGER RNA; TESTOSTERONE; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; INSECT REPELLENT; INSECTICIDE; ISOENZYME;

APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENVIRONMENTAL EXPOSURE; ENZYME INDUCTION; ENZYME SPECIFICITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN IMPACT (ENVIRONMENT); LIVER CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; TESTOSTERONE METABOLISM; TOXICOKINETICS; BIOSYNTHESIS; CELL CULTURE; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; TOXICITY; TUMOR CELL CULTURE;

ADENYLATE KINASE; CASPASE 3; CASPASE 7; CELL DEATH; CELLS, CULTURED; CHLORPYRIFOS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEET; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; INSECT REPELLENTS; INSECTICIDES; ISOENZYMES; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 60749088324     PISSN: 07925077     EISSN: None     Source Type: Journal    
DOI: 10.1515/DMDI.2008.23.3-4.237     Document Type: Article

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