Blood pressure and heart rate QTL in mice of the B6/D2 lineage: Sex differences and environmental influences

Physiological Genomics

Volumn 36, Issue 3, 2009, Pages 158-166

  Blizard, David A ^a   Lionikas, Arimantas ^a   Vandenbergh, David J ^a   Vasilopoulos, Terrie ^a   Gerhard, Glenn S ^b   Griffith, James W ^c   Klein, Laura C ^a   Stout, Joseph T ^a   Mack, Holly A ^a   Lakoski, Joan M ^d   Larsson, Lars ^a,e   Spicer, Jeanne M ^a   Vogler, George P ^a   McClearn, Gerald E ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b GEISINGER MEDICAL CENTER   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e UPPSALA UNIVERSITY   (Sweden)

Author keywords

Quantitative trait locus; Sex specificity; Stress

Indexed keywords

MITOCHONDRIAL DNA;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; C57BL 6 MOUSE; CARDIOVASCULAR FUNCTION; CHROMOSOME 14; CHROMOSOME 4; CONTROLLED STUDY; CUFF; DBA 2 MOUSE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; ENVIRONMENTAL STRESS; FEMALE; GENETIC ANALYSIS; GENETIC CORRELATION; HEART RATE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SEX DIFFERENCE; STRAIN DIFFERENCE; SYSTOLIC BLOOD PRESSURE; TAIL;

ANIMALS; BLOOD PRESSURE; CHROMOSOME MAPPING; CHROMOSOMES, MAMMALIAN; EPISTASIS, GENETIC; FEMALE; GENOTYPE; HEART RATE; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, INBRED STRAINS; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; SEX FACTORS; STRESS, PHYSIOLOGICAL;

MUS;

EID: 60549086144     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00035.2008     Document Type: Article

References (76)

1. Alyonycheva T, Cohen-Gould L, Siewert C, Fischman DA, Mikawa T. Skeletal muscle-specific myosin binding protein-H is expressed in Purkinje fibers of the cardiac conduction system. Circ Res 80: 665-672, 1997.
2. Belknap JK, Mitchell SR, O'Toole LA, Helms ML, Crabbe JC. Type I and type II error rates for quantitiative trait loci (QTL) mapping studies using recombinant-inbred mouse strains. Behav Genet 26: 149-160, 1996.
3. Bers DM. Cardiac excitation-contraction coupling. Nature 415: 198-205, 2002.
4. Blizard DA, Bailey DW. Genetic correlation between open-field activity and defecation: analysis with CXB recombinant-inbred strains. Behav Genet 9: 349-357, 1979.
5. Blizard DA, Welty R. Cardiac activity in the mouse: strain differences. J Comp Physiol Psychol 77: 337-344, 1971.
6. Brodde OE, Bruck H, Leineweber K. Cardiac adrenoceptors: physiological and pathophysiological relevance. J Pharm Sci 100: 323-337, 2006.
7. Broman KW. Mapping quantitative trait loci in the case of a spike in the phenotype distribution. Genetics 163: 1169 -1175, 2003.
8. Carrier L, Bonne G, Bahrend E, Yu B, Richard P, Niel F, Hainque B, Cruaud C, Gary F, Labeit S, Bouhour JB, Dubourg O, Desnos M, Hagege AA, Trent RJ, Komajda M, Fiszman M, Schwartz K. Organization, and sequence of human cardiac myosin binding protein C gene (MYBPC3) and identification of mutations predicted to produce truncated proteins in familial hypertrophic cardiomyopathy. Circ Res 80: 427-434, 1997.
9. Churchill GA. Recombinant inbred strain panels: a tool for systems genetics. Physiol Genomics 31: 174-175, 2007.
10. Churchill GA, Doerge RW. Empirical threshold values for quantitative trait mapping. Genetics 138: 963-971, 1994.
11. Cowley AW Jr. The genetic dissection of essential hypertension. Nat Rev Genet 7: 829-840, 2006.
12. Cui JS, Hopper JL, Harrap SB. Antihypertensive treatments obscure familial contributions to blood pressure variation. Hypertension 41: 207-210, 2003.
13. 2+(i) in female rat cardiac myocytes. Clin Exp Pharm Physiol 30: 489-494, 2003.
14. DiPetrillo K, Tsaih SW, Sheehan S, Johns C, Kelmenson P, Gavras H, Churchill GA, Paigen B. Genetic analysis of blood pressure in C3H/HeJ and SWR/J mice. Physiol Genomics 17: 215-220, 2004.
15. Du XJ, Fang L, Kiriazis H. Sex dimorphism in cardiac pathophysiology: experimental findings, hormonal mechanisms, and molecular mechanisms. Pharm Ther 111: 434-475, 2006.
16. Garrett MR, Rapp JP. Defining the blood pressure QTL on chromosome 7 in Dahl rats by a 177-kb congenic segment containing Cyp11b1. Mamm Genome 14: 268-273, 2003.
17. Gomez-Fabre PM, Helou K, Stahl F. Predictions based on the rat-mouse comparative map provide mapping information on over 6000 new rat genes. Mamm Genome 13: 189-193, 2002.
18. Gross V, Tank J, Obst M, Plehm R, Blumer KJ, Diedrich A, Jordan J, Luft FC. Autonomic nervous system and blood pressure regulation in RGS2-deficient mice. Am J Physiol Regul Integr Comp Physiol 288: R1134-R1142, 2005.
19. Hamet P, Merlo E, Seda O, Broeckel U, Tremblay J, Kaldunski M, Gaudet D, Bouchard G, Deslauriers B, Gagnon F, Antoniol G, Pausová Z, Labuda M, Jomphe M, Gossard F, Tremblay G, Kirova R, Tonellato P, Orlov SN, Pintos J, Platko J, Hudson TJ, Rioux JD, Kotchen TA, Cowley AW Jr. Quantitative founder-effect analysis of French Canadian families identifies specific loci contributing to metabolic phenotypes of hypertension. Am J Hum Genet 76: 815-32, 2005.
20. Hamilton M, Pickering GW, Roberts JAF, Sowry GSC. The aetiology of hypertension. 4 The role of inheritance. Clin Sci 13: 273, 1954.
21. Heximer SP, Knutsen RH, Sun XG, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wyss JM, Mecham RP, Blumer KJ. Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest 111:1259-1259, 2003.
22. Hunt SC, Ellison RC, Atwood LD, Pankow JS, Province MA, Leppert MF. Genome scans for blood pressure, and hypertension: the National Heart, Lung, and Blood Institute Family Heart Study. Hypertension 40:1-6, 2002.
23. Jaworski R, Jirout M, Closson S, Breen L, Flodman PL, Spence MA, Kren V, Krenova D, Pravenec M, Printz MP. Heart rate and blood pressure quantitative trait loci for the airpuff startle reaction. Hypertension 39: 348-352, 2002.
24. Joe B, Garrett MR, Dene H, Rapp JP. Substitution mapping of a blood pressure quantitative trait locus to a 2.73 Mb region on rat chromosome 1. J Hypertens 21: 2077-2084, 2003.
25. Johnson BD, Zheng W, Korach KS, Scheuer T, Catterall WA, Rubanyi GM. Increased expression of the cardiac L.-type calcium channel in estrogen receptor-deficient mice. J Gen Physiol 110: 135-140, 1997.
26. Klein RF. Genetic regulation of bone mineral density in mice. J Musculoskelet Neuronal Interact 2: 232-236, 2002.
27. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genetics 11: 241-247, 1995.
28. Levan G, Szpirer J, Szpirer C, Klinga K, Hanson C, Islam MQ. The gene map of the Norway rat (Rattus norvegicus) and comparative mapping with mouse and man. Genomics 10: 699 -718, 1991.
29. Martin LJ, Comuzzie AG, Sonnenberg GE, Myklebust J, James R, Marks J, Blangero J, Kissebah AH. Major quantitative trait locus for resting heart rate maps to a region on chromosome 4. Hypertension 43: 1146-1151, 2004.
30. McBride MW, Carswell HV, Graham D, Carr FJ, Charchar FJ, Macrae IM, Dominiczak AFD. Genetic and gender determinants of cerebrovascular disease. Sem Nephrol 22: 127-134, 2002.
31. Meng H, Garrett MR, Dene H, Rapp JP. Localization of a blood pressure QTL to a 2.4-cM interval on rat chromosome 9 using congenic strains. Genomics 81: 210-220, 2003.
32. Miall WE, Oldham PD. A study of arterial blood pressure and its inheritance in a sample of the general population. Clin Sci (Lond) 14:459-488, 1955.
33. Ostchega Y, Dillon CF, Hughes JP, Carroll M, Yoon S. Trends in hypertension prevalence, awareness, treatment, and control in older U.S. adults: data from the National Health and Nutrition Examination Survey 1988 to 2004. J Am Geriatr Soc 55: 1056-1065, 2007.
34. Park ES, Echetebu CO, Soloff S, Soloff MS. Oxytocin stimulation of RGS2 mRNA expression in cultured human myometrial cells. Am J Physiol Endocrinol Metab 282: E580-E584, 2002.
35. Park SJ, Choi DJ, Kim CW. Hypertensive left ventricular hypertrophy: relation to beta-adrenergic receptor kinase-1 (betaARK1) in peripheral lymphocytes. J Hypertens 22: 1025-32, 2004.
36. Pravenec M, Zidek V, Musilova A, Vorlicek J, Kren V, St Lezin E, Kurtz TW. Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat. J Hypertens 19:1061-1064, 2001.
37. Pravenec M, Kren V, Krenova D, Zidek V, Simakova M, Musilova A, Vorlicek J, Lezin ES, Kurtz TW. Genetic isolation of quantitative trait loci for blood pressure development, and renal mass on chromosome 5 in the spontaneously hypertensive rat. Physiol Res 52: 285-289, 2003.
38. Province MA, Kardia SLR, Ranade K, Rao DC, Thiel BA, Cooper RS, Risch N, Turner ST, Cox DR, Hunt SC, Weder AB, Boerwinkle EA. Meta-analysis of genome-wide linkage scans for hypertension: the National Heart Lung and Blood Institute Family Blood Pressure Program. Am J Hypertens 16: 144-147, 2003.
39. Ramensky V, Bork P, Sunyaev S. Human non-synonymous SNPs: server and survey. Nucleic Acids Res 30: 3894-3900, 2002.
40. Rao DC, Province MA, Leppert MF, Oberman A, Heiss G, Ellison RC, Arnett DK, Eckfeldt JH, Schwander K, Mockrin SC, Hunt SC. A genome-wide affected sibpair linkage analysis of hypertension: the HyperGEN Network. Am J Hypertens 16: 148-150, 2003.
41. Rapp JP. Genetic analysis of inherited hypertension in the rat. Physiol Res 80: 135-172, 2000.
42. Rice T, Rankinen T, Province MA, Chagnon YC, Pérusse L, Borecki IB, Bouchard C, Rao DC. Genome-wide linkage analysis of systolic and diastolic blood pressure: the Québec Family Study. Circulation 102:1956 -1963, 2000.
43. Rice T, Rankinen T, Chagnon YC, Province MA, Pérusse L, Leon AS, Skinner JS, Wilmore JH, Bouchard C, Rao DC. Genome-wide linkage scan of resting blood pressure: HERITAGE Family Study. Health, risk factors, exercise training, and genetics. Hypertension 39: 1037-1043, 2002.
44. Riddle EL, Rana BK, Murthy KK, Rao FW, Eskin E, O'Connor DT, Insel PA. Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives. Hypertension 47:415-420, 2006.
45. Rollins J, Chen Y, Paigen B, Wang X. In search of new targets for plasma high-density lipoprotein cholesterol levels: promise of human- mouse comparative genomics. Trends Cardiovasc Med 16, 220-34, 2006.
46. Saad Y, Garrett MR, Manickavasagam E, Yerga-Woolwine S, Farms P, Radecki T, Joe B. Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10. Genomics 89: 343-353, 2007.
47. Schlager G. Heritability of blood pressure in mice. J Hered 56: 278 -284, 1965.
48. Schlager G. Genetic and physiological studies of blood pressure in mice. I. Crosses between A/J, SWR/J and their hybrids. Can J Genet Cytol 10:853-864, 1968.
49. Schlager G. Selection for blood pressure levels in mice. Genetics 76:537-549, 1974.
50. Schlager G. Biometrical genetic analysis of blood pressure levels in the genetically hypertensive mouse. Clin Exp Hypertens 16: 809 -824, 1994.
51. Schlager G, El Seoudy AA. Genetic analysis of blood pressure levels in the genetically hypertensive mouse. In: Hypertensive mechanisms-The Spontaneously Hypertensive Rat as a Model to Study Human Hypertension edited by Rascher W, Clough D, Ganten D. Stuttgart: Schattauer Verlag, 1982, p. 147-150.
52. Schlager G, Weibust RS. Genetic control of blood pressure in mice. Genetics 55: 497-506, 1967.
53. Schmidt C, Gonzaludo NP, Strunk S, Dahm S, Schuchhardt J, Kleinjung F, Wuschke S, Joost HG, Al-Hasani H. A meta-analysis of QTL for diabetes-related traits in rodents. Physiol Genomics 34: 42-53, 2008.
54. Seisenberger C, Specht V, Welling A, Platzer J, Pfeifer A, Kühbandner S, Striessnig J, Klugbauer N, Feil R, Hofmann F. Functional embryonic cardiomyocytes after disruption of the L-type alpha(1C) [Ca(v)1.2] calcium channel gene in the mouse. J Biol Chem 275: 39193-39199, 2000.
55. Serikawa T, Cui Z, Yokoi N, Kuramoto T, Kondo Y, Kitada K, Guenet JL. A comparative genetic map of rat, mouse and human genomes. Exp Anim 47: 1-9, 1998.
56. Silva GJJ, Pereira AC, Krieger EM, Krieger JE. Genetic mapping of a new heart rate QTL on chromosome 8 of spontaneously hypertensive rats. BMC Med Genet 8: 17, 2007.
57. Stevenson JC. Various actions of oestrogens on the vascular system. Maturitas 30: 5-9, 1998.
58. Stoll M, Cowley AW Jr, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, Dumas P, Schork NJ, Wang Z, Jacob HJ. A genomic- systems biology map for cardiovascular function. Science 294: 1723-1726, 2001.
59. Stoll M, Kwitek-Black AE, Cowley AW Jr, Harris EL, Harrap SB, Krieger JE, Printz MP, Provoost AP, Sassard J, Jacob HJ. New target regions for human hypertension via comparative genomics. Genome Res 10: 473- 482, 2000.
60. Sugiyama F, Churchill GA, Higgins DC, Johns C, Makaritsis KP, Haralambos G, Paigen B. Concordance of murine quantitative QTL for salt-induced hypertension with rat and human loci. Genomics 71: 70 -77, 2001.
61. Sugiyama F, Churchill GA, Li R, Libby LJ, Carver T, Yagami K, John SW, Paigen B. QTL associated with blood pressure, heart rate and heart weight in CBA/CaJ and BALB/cJ mice. Physiol Genomics 10: 5-12, 2002.
62. Sun XG, Kaltenbronn KM, Steinberg TH, Blumer KJ. RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling. Mol Pharmacol 67:631-639, 2005.
63. 2+ channel from Cav1.3 to Cav12 in embryonic murine ventricle. Circ J 69: 1405-1411, 2005.
64. Tang M, Wang G, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME. Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med 9: 1506 -1512, 2003.
65. Tarantino LM, McClearn GE, Rodriguez LA, Plomin R. Confirmation of quantitative ttrait loci for alcohol preference in mice Alc. Clin Exp Res 22: 1099-1105, 1998.
66. Taylor BA. Recombinant-inbred strains: use in gene-mapping. In: Origins of Inbred Mice, edited by Morse H. New York: Academic, 1978, 423-438.
67. Taylor BA, Wnek C, Kotlus BS, Roemer N, MacTaggart T, Phillips SJ. Genotyping new BXD recombinant inbred mouse strains and comparison of BXD and consensus maps. Mamm Genome 10: 335-348, 1999.
68. Vandenbergh DJ, Heron K, Peterson R, Shpargel KB, Woodroffe A, Blizard DA, McClearn GE, Vogler GP. Simple tests to detect errors in high-throughput genotype data in the molecular laboratory. J Biomol Techn 14: 9-16, 2003.
69. Wang X, Ishimori N, Korstanje R, Rollins J, Paigen B. Identifying novel genes for atherosclerosis through mouse-human comparative genetics. Am J Hum Genet 77: 1-15, 2005.
70. Wang X, Paigen B. Quantitative trait loci and candidate genes regulating HDL cholesterol: a murine chromosome map. Arterioscler Thromb Vasc Biol 22: 1390-1401, 2002.
71. Wang X, Paigen B. Genome-wide search for new genes controlling plasma lipid concentrations in mice and humans. Curr Opin Lipidol 16:127-137, 2005.
72. Weiss LA, Pan L, Abney M, Ober C. The sex-specific genetic architecture of quantitative traits in humans. Nat Genet 38: 218 -222, 2006.
73. Williams RW, Gu J, Qi S, Lu L. The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis. Genome Biol 2: 11, RESEARCH0046, 2001.
74. Woo DL, Kurtz I. Mapping blood pressure loci in (A/J X B6)F2 mice. Physiol Genomics 15: 236-242, 2003.
75. Wright FA, O'Connor DT, Roberts E, Kutey G, Berry CC, Yoneda LU, Timberlake D, Schlager G. Genome scan for blood pressure loci in mice. Hypertension 34: 625-630, 1999.
76. Wurmbach E, Yuen T, Ebersole BJ, Sealfon SC. Gonadotropin- releasing hormone receptor-coupled gene network organization. J Biol Chem 276: 47195-47201, 2001.