Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains

Behavior Genetics

Volumn 26, Issue 2, 1996, Pages 149-160

  Belknap, J K ^a,b   Mitchell, S R ^a,b   O'Toole, L A ^a,b   Helms, M L ^a,b   Crabbe, J C ^a,b  

^a PORTLAND VA MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

BXD; C57BL 6; DBA 2; QTL mapping; recombinant inbred strains

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; ERROR; GENE LOCUS; GENE MAPPING; MOUSE; MULTIFACTORIAL INHERITANCE; NONHUMAN; QUANTITATIVE TRAIT;

ANIMALS; CHROMOSOME MAPPING; COMPUTER SIMULATION; FEMALE; GENETIC MARKERS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, INBRED STRAINS; MODELS, GENETIC; PHENOTYPE; RECOMBINATION, GENETIC;

ANIMALIA;

EID: 0029878553     PISSN: 00018244     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02359892     Document Type: Article

References (44)

1. Bailey, D. W. (1981). Recombinant inbred strains and bilineal congenic strains. In Foster, H. L., Small, J. D., and Fox, J. G. (eds.), The Mouse in Biomedical Research, Vol. 1, Academic Press, New York, pp. 223-239.
2. Belknap, J. K. (1992). Empirical estimates of Bonferroni corrections for use in chromosome mapping studies with the BXD recombinant inbred strains. Behav. Genet. 22:677-684.
3. Belknap, J. K., Metten, P. A., Helms, M. L., O'Toole, L. A., Angeli-Gade, S., Crabbe, J. C., and Phillips, T. J. (1993). Quantitative trait loci (QTL) applications to substances of abuse: Physical dependence studies with nitrous oxide and ethanol. Behav. Genet. 23:211-220.
4. Belknap, J. K., Mogil, J. S., Helms, M. L., Richards, S. P., O'Toole, L. A., Bergeson, S. E., and Buck, K. J. (1995). Localization to chromosome 10 of a locus influencing morphine-induced analgesia in crosses derived from C57BL/6 and DBA/2 mice. Life Sci. (Pharmacol. Lett.) 57:PL117-PL124.
5. Berrettini, W. H., Ferraro, T. N., Alexander, R. C., Buchberg, A. M., and Vogel, W. H. (1994). Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains. Nature Genet. 7:54-58.
6. Buck, K. J. (1995). Strategies for mapping and identifying quantitative trait loci specifying behavioral responses to alcohol. Alc. Clin. Exp. Res. 19:795-801.
7. Crabbe, J. C., Belknap, J. K., and Buck, K. J. (1994a). Genetic animal models of alcohol and drug abuse. Science 264: 1715-1723.
8. Crabbe, J. C., Belknap, J. K., Buck, K. J., and Metten, P. (1994b). Use of recombinant inbred strains for studying genetic determinants of responses to alcohol. Alcohol Alcohol. 52:69-73.
9. Crabbe, J. C., Buck, K. J., Metten, P., and Belknap, J. K. (1995). Strategies for identifying genes underlying drug abuse susceptibility. In Lee, T. N. H. (ed.), Molecular Approaches to Drug Abuse Research, Vol. III, NIDA Res. Monogr., USGPO, Washington, DC.
10. Darvasi, A., Weinreb, A., Minke, V. Weller, J. I., and Soller, M. (1993). Detecting marker-QTL linkage and estimating QTL gene effect and map location using a saturated genetic map. Genetics 134:943-951.
11. DeFries, J. C., Wilson, J. R., Erwin, V. G., and Petersen, D. R. (1989). LSXSS recombinant inbred strains of mice: Initial characterization. Alc. Clin. Exp. Res. 13:196-200.
12. Dietrich, W., Katz, H., Lincoln, S. E., Shin, H.-S., Friedman, J., Dracopoli, N. C., and Lander, E. S. (1992). A genetic map of the mouse suitable for typing intraspecific crosses. Genetics 131:423-447.
13. Fisher, R. A. (1958). Statistical Methods for Research Workers, 13th ed., Hafner, New York, pp. 99-101.
14. Flint, J., Corley, R., DeFries, J. C., Fulker, D. W., Gray, J. A., Miller, S., and Collins, A. C. (1995). A simple genetic basis for a complex psychological trait in laboratory mice. Science 269:1432-1435.
15. Goldman, D., Lister, R. G., and Crabbe, J. C. (1987). Mapping of a putative genetic locus determining ethanol intake in the mouse. Brain Res. 420:220-226.
16. Groot, P. C., Moen, C. J. A., Dietrich, W., Stoye, J. P., Lander, E. S., and DeMant, P. (1992). The recombinant congenic strains for analysis of multigenic traits: Genetic composition. FASEB J. 6:2826-2835.
17. Hegmann, J., and Possidente, B. (1981). Estimating genetic correlations from inbred strains. Behav. Genet. 11:103-114.
18. Hubert, P., Lindpainter, K., Beckmann, J. S., Serikawa, T., Soubrier, F., Dubay, C. S., Cartwright, P., DeGouyon, B., Julier, C., Takahasi, S., Vincent, M., Ganten, D., Georges, M., and Lathrop, G. M. (1991). Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature 353:521-529.
19. Jacob, H. J., Lindpaintner, K., Lincoln, S. E., Kusumi, K., Bunker, R. K., Mao, Y.-P., Ganten, D., Dzau, V. J., and Lander, E. S. (1991). Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell 67:213-224.
20. Johnson, T. E., DeFries, J. C., and Markel, P. (1992). Mapping quantitative trait loci for behavioral traits in the mouse. Behav. Genet. 22:635-653.
21. Lander, E. S., and Schork, N. J. (1994). Genetic dissection of complex traits. Science 265:2037-2048.
22. Lander, E. S., and Botstein, D. (1989). Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121:185-199.
23. Manly, K. E. (1993). A Macintosh program for storage and analysis of experimental genetic mapping data. Mammal. Genome 4:303-313.
24. Manly, K. E., and Cudmore, R. (1994). Map Manager; A Program for Genetic Mapping (v. 2.6), Roswell Park Cancer Institute, Buffalo, NY.
25. Markel, P. D., Fulker, D. W., Bennett, B., Corley, R. P., DeFries, J. C., Erwin, V. G., and Johnson, T. E. (1996). Quantitative trait loci for ethanol sensitivity in the LSXSS recombinant inbred strains: Interval mapping. Behav. Genet. (in press).
26. Marshall, J. D., Mu, J.-L., Cheah, Y.-C., Nesbitt, M. N., Frankel, W. N., and Paigen, B. (1992). The AXB and BXA set of recombinant inbred mouse strains. Mammal. Genome 3:669-680.
27. Miller, R. G., Jr. (1981). Simultaneous Statistical Inference, McGraw-Hill, New York.
28. Neumann, P. E. (1992). Inference in linkage analysis of multifactorial traits using recombinant inbred strains of mice. Behav. Genet. 22:665-676.
29. Oliverio, A., and Eleftheriou, B. E. (1976). Motor activity and alcohol: A genetic investigation in the mouse. Physiol. Behav. 16:577-581.
30. Ott, J. (1991). Analysis of Human Genetic Linkage, Johns Hopkins Press, Baltimore, MD.
31. Phillips, T. J., Crabbe, J. C., Metten, P., and Belknap, J. K. (1994). Localization of genes affecting alcohol drinking in mice. Alc. Clin Exp. Res. 18:931-941.
32. Plomin, R., McClearn, G. E., and Gora-Maslak, G. (1991). Use of recombinant inbred strains to detect quantitative trait loci associated with behavior. Behav. Genet. 21:99-116.
33. 1 crosses between BXD recombinant inbred strains to replicate BXD-nominated quantitative trait loci (QTL). Alc. Clin. Exp. Res. (in press).
34. Rice, W. R. (1989). Analyzing tables of statistical tests. Evolution 43:223-225.
35. Rise, M. T., Frankel, W. N., Coffin, J. M., and Seyfried, T. N. (1991). Genes for epilepsy mapped in the mouse. Science 253:669-673.
36. Silver, J. (1985). Confidence limits for estimates of gene linkage based on analysis of recombinant inbred strains. J. Hered. 76:436-440.
37. Silver, L. M., Nadeau, J. H., and Goodfellow, P. N. (1994). Encyclopedia of the mouse genome IV. Mammal. Genome 5:S1-S295 (Special issue).
38. Simpson, S. P. (1989). Detection of linkage between quantitative trait loci and restriction fragment length polymorphisms using inbred lines. Theor. Appl. Genet. 77:815-819.
39. Sokal, R. R., and Rohlf, F. J. (1981). Biometry, Freeman, San Francisco.
40. Soller, M., Brody, T., and Genizi, A. (1976). On the power of experimental designs for the detection of linkage between marker loci and quantitative loci in crosses between inbred lines. Theoret. Appl. Genet. 47:35-39.
41. Tanksley, S. D. (1993). Mapping polygenes. Annu. Rev. Genet. 27:205-233.
42. Taylor, B. A. (1978). Recombinant inbred strains: Use in gene mapping. In Morse, H. C. (ed.), Origins of Inbred Mice, Academic Press, New York, pp. 423-438.
43. Taylor, B. A. (1989). Recombinant inbred strains. In Lyon, M. F., and Searle, A. G. (eds.), Genetic Variants and Strains of the Laboratory Mouse, 2nd ed., Oxford University Press, Oxford, pp. 773-789.
44. Wilkinson, L. (1990). Systat: The System for Statistics, Systat, Inc., Evanston, IL.