Autonomic nervous system and blood pressure regulation in RGS2-deficient mice

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 288, Issue 5 57-5, 2005, Pages

  Gross, Volkmar ^a   Tank, Jens ^b   Obst, Michael ^a   Plehm, Ralph ^a   Blumer, Kendall J ^c   Diedrich, Andrè ^d   Jordan, Jens ^b   Luft, Friedrich C ^a,b  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VANDERBILT UNIVERSITY   (United States)

Author keywords

Autonomic nervous system; Baroreflex; G protein coupled receptors; Heart rate variability; RGS2 deficient mice; Spectral analysis; Telemetry

Indexed keywords

ATROPINE; G PROTEIN COUPLED RECEPTOR; METOPROLOL; NORADRENALIN; PRAZOSIN; RGS2 PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE REGULATION; GENE DELETION; HEART RATE; HEART RATE VARIABILITY; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; NORADRENALIN URINE LEVEL; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPECTROSCOPY; STRESS; TELEMETRY; URINARY EXCRETION;

ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ATROPINE; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; CIRCADIAN RHYTHM; EPINEPHRINE; HEART RATE; MALE; METOPROLOL; MICE; MICE, KNOCKOUT; NOREPINEPHRINE; PARASYMPATHOLYTICS; PRAZOSIN; RGS PROTEINS; STRESS;

EID: 17844407896     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00246.2004     Document Type: Article

References (37)

1. Biaggioni I. Sympathetic control of the circulation in hypertension: lessons from autonomic disorders. Curr Opin Nephrol Hypertens 12: 175-180, 2003.
2. Boehm S. Signaling via nucleotide receptors in the sympathetic nervous system. Drug News Perspect 16: 141-148, 2003.
3. deBoer RW, Karemaker JM, and Strackee J. Hemodynamic fluctuations and baroreflex sensitivity in humans: a beat-to-beat model. Am J Physiol Heart Circ Physiol 253: H680-H689, 1987.
4. Duka I, Gavras I, Johns C, Handy DE, and Gavras H. Role of the postsynaptic alpha(2)=adrenergic receptor subtypes in catecholamine-induced vasoconstriction. Gen Pharmacol 34: 101-106, 2000.
5. Eckhart AD, Ozaki T, Tevaearai H, Rockman HA, and Koch WJ. Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure. Mol Pharmacol 61: 749-758, 2002.
6. Esler M, Rumantir M, Kaye D, Jennings G, Hastings J, Socratous F, and Lambert G. Sympathetic nerve biology in essential hypertension. Clin Exp Pharmacol Physiol 28: 986-989, 2001.
7. Gehrmann J, Hammer PE, Maguire CT, Wakimoto H, Triedman JK, and Berul CI. Phenotypic screening for heart rate variability in the mouse. Am J Physiol Heart Circ Physiol 279: H733-H740, 2000.
8. Gross V, Plehm R, Tank J, Jordan J, Diedrich A, Obst M, and Luft FC. Heart rate variability and barorefiex function in AT2 receptor-disrupted mice. Hypertension 40: 207-213, 2002.
9. Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wyss JM, Mecham RP, and Blumer KJ. Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest 111: 445-452, 2003.
10. Heximer SP, Watson N, Linder ME, Blumer KJ, and Hepler JR. RGS2/G0S8 is a selective inhibitor of Gqalpha function. Proc Natl Acad Sci USA 94: 14389-14393, 1997.
11. Ingi T, Krumins AM, Chidiac P, Brothers GM, Chung S, Snow BE, Barnes CA, Lanahan AA, Siderovski DP, Ross EM, Gilman AG, and Worley PF. Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity. J Neurosci 18: 7178-7188, 1998.
12. Janssen BJ, Leenders PJ, and Smits JF. Short-term and long-term blood pressure and heart rate variability in the mouse. Am J Physiol Regul Integr Comp Physiol 278: R215-R225, 2000.
13. Janssen BJ and Smits JF. Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification. Am J Physiol Regul Integr Comp Physiol 282: R1545-R1564, 2002.
14. Japundzic N, Grichois ML, Zitoun P, Laude D, and Elghozi JL. Spectral analysis of blood pressure and heart rate in conscious rats: effects of autonomic blockers. J Auton Nerv Syst 30: 91-100, 1990.
15. Just A, Faulhaber J, and Ehmke H. Autonomic cardiovascular control in conscious mice. Am J Physiol Regul Integr Comp Physiol 279: R2214-R2221, 2000.
16. Lanfranchi PA and Somers VK. Arterial baroreflex function and cardiovascular variability: interactions and implications. Am J Physiol Regul Integr Comp Physiol 283: R815-R826, 2002.
17. Larminie C, Murdock P, Walhin JP, Duckworth M, Blumer KJ, Scheideler MA, and Gamier M. Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system. Brain Res Mol Brain Res 122: 24-34, 2004.
18. Le TH and Coffman TM. RGS2: a "turn-off" in hypertension. J Clin Invest 111: 441-443, 2003.
19. Levy D and Kannel WB. Cardiovascular risks: new insights from Framingham. Am Heart J 116: 266-272, 1988.
20. Lohmeier TE. The sympathetic nervous system and long-term blood pressure regulation. Am J Hypertens 14: 147S-154S, 2001.
21. Mancia G, Frattola A, Parati G, Santucciu C, and Ulian L. Blood pressure variability and organ damage. J Cardiovasc Pharmacol 24, Suppl A: S6-S11, 1994.
22. Mansier P, Clairambault J, Charlotte N, Medigue C, Vermeiren C, LePape G, Carre F, Gounaropoulou A, and Swynghedauw B. Linear and nonlinear analyses of heart rate variability: a minireview. Cardiovasc Res 31: 371-379, 1996.
23. Mansier P, Medigue C, Charlotte N, Vermeiren C, Coraboeuf E, Deroubai E, Ratner E, Chevalier B, Clairambault J, Carre F, Dahkli T, Bertin B, Briand P, Strosberg D, and Swynghedauw B. Decreased heart rate variability in transgenic mice overexpressing atrial beta 1-adrenoceptors. Am J Physiol Heart Circ Physiol 271: H1465-H1472, 1996.
24. Mattes A, Witte K, Hohmann W, and Lemmer B. PHARMFIT-a nonlinear fitting program for pharmacology. Chronobiol Int 8: 460-476, 1991.
25. Michelini LC, Marcelo MC, Amico J, and Morris M. Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice. Am J Physiol Heart Circ Physiol 284: H2269-H2276, 2003.
26. Obst M, Gross V, Bonartsev A, Janke J, Muller DN, Park JK, Kargel E, and Luft FC. Nitric oxide synthase expression in AT2 receptor-deficient mice after DOCA-salt. Kidney Int 65: 2268-2278, 2004.
27. Oh-Hashi Y, Shindo T, Kurihara Y, Imai T, Wang Y, Monta H, Imai Y, Kayaba Y, Nishimatsu H, Suematsu Y, Hirata Y, Yazaki Y, Nagai R, Kuwaki T, and Kurihara H. Elevated sympathetic nervous activity in mice deficient in alphaCGRP. Circ Res 89: 983-990, 2001.
28. Oliveira-Dos-Santos AJ, Matsumoto G, Snow BE, Bai D, Houston FP, Whishaw IQ, Mariathasan S, Sasaki T, Wakeham A, Ohashi PS, Roder JC, Barnes CA, Siderovski DP, and Penninger JM. Regulation of T cell activation, anxiety, and male aggression by RGS2. Proc Natl Acad Sci USA 97: 12272-12277, 2000.
29. Parati G, Di Rienzo M, Castiglioni P, Bouhaddi M, Cerutti C, Cividjian A, Elghozi JL, Fortrat JO, Girard A, Janssen BJ, Julien C, Karemaker JM, Iellamo F, Laude D, Lukoshkova E, Pagani M, Persson PB, Quintin L, Regnard J, Ruediger JH, Saul PJ, Vettorello M, Wesseling KH, and Mancia G. Assessing the sensitivity of spontaneous baroreflex control of the heart: deeper insight into complex physiology. Hypertension 43: e32-e34, 2004.
30. Parlow J, Viale JP, Annat G, Hughson R, and Quintin L. Spontaneous cardiac baroreflex in humans. Comparison with drug-induced responses. Hypertension 25: 1058-1068, 1995.
31. Stauss HM. Heart rate variability. Am. J Physiol Regul Integr Comp Physiol 285: R927-R931, 2003.
32. Tang M, Wang G, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, and Mendelsohn ME. Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med 9: 1506-1512, 2003.
33. Tank J, Jordan J, Diedrich A, Obst M, Plehm R, Luft FC, and Gross V. Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation. Hypertension 43: 1042-1047, 2004.
34. Uechi M, Asai K, Osaka M, Smith A, Sato N, Wagner TE, Ishikawa Y, Hayakawa H, Vatner DE, Shannon RP, Homcy CJ, and Vatner SF. Depressed heart rate variability and arterial baroreflex in conscious transgenic mice with overexpression of cardiac Gsalpha. Circ Res 82: 416-423, 1998.
35. Westermann J, Hubl W, Kaiser N, and Salewski L. Simple, rapid and sensitive determination of epinephrine and norepinephrine in urine and plasma by non-competitive enzyme immunoassay, compared with HPLC method. Clin Lab 48: 61-71, 2002.
36. Wickman K, Nemec J, Gendler SJ, and Clapham DE. Abnormal heart rate regulation in GIRK4 knockout mice. Neuron 20: 103-114, 1998.
37. Zolk O, Kouchi I, Schnabel P, and Bohm M. Heterotrimeric G proteins in heart disease. Can J Physiol Pharmacol 78: 187-198, 2000.