cAMP-dependent protein kinase mediates activity-regulated synaptic targeting of NMDA receptors

Journal of Neuroscience

Volumn 21, Issue 14, 2001, Pages 5079-5088

  Crump, F Thomas ^b   Dillman, Keith S ^b   Craig, Ann Marie ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Activity; Excitotoxicity; Hippocampus; NMDA receptor; NR1 GFP; Subcellular localization; Synaptic clustering; Synaptogenesis

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP PHOSPHODIESTERASE; GLUTAMIC ACID; GREEN FLUORESCENT PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHODIESTERASE INHIBITOR;

ANIMAL CELL; ARTICLE; CENTRAL NERVOUS SYSTEM DEPRESSION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME REGULATION; GENE CLUSTER; GENE TARGETING; HIPPOCAMPUS; LONG TERM POTENTIATION; NERVE CELL EXCITABILITY; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RAT; RECEPTOR BLOCKING; REGULATORY MECHANISM; SYNAPTOGENESIS;

EID: 0035879068     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-14-05079.2001     Document Type: Article

References (50)

1. Metaplasticity: The plasticity of synaptic plasticity
2. Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: Maintenance of core components independent of actin filaments and microtubules
3. Mechanism for a sliding synaptic modification threshold
4. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains
5. A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain
6. Glutamate receptors and the induction of excitotoxic neuronal death
7. Preferential addition of newly synthesized membrane protein at axonal growth cones
8. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures
9. An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy
10. NMDA receptor upregulation: Molecular studies in cultured mouse cortical neurons after chronic antagonist exposure
11. Seizure-like activity and cellular damage in rat hippocampal neurons in cell culture
12. Hippocampal neurons in low density culture
13. Function of calmodulin in postsynaptic densities. I. Presence of a calmodulin-activatable cyclic nucleotide phosphodiesterase activity
14. Differential surface expression and phosphorylation of the N-methyl-D-aspartate receptor subunits NR1 and NR2 in cultured hippocampal neurons
15. A novel multiple PDZ domaincontaining molecule interacting with N-methyl-Md-aspartate receptors and neuronal cell adhesion proteins
16. Formation of temporal memory requires NMDA receptors within CA1 pyramidal neurons
17. Block of N-methyl-Md-aspartate-activated current by the anticonvulsant MK-801: Selective binding to open channels
18. Characterization of MALS/Velis-1, -2, and -3: A family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex
19. Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1)
20. Interaction of ion channels and receptors with PDZ domain proteins
21. Cyclic AMP-dependent protein kinase and protein kinase C phosphorylate N-methyl-Md-aspartate receptors at different sites
22. Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons
23. A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory
24. Role of AMPA receptor cycling in synaptic transmission and plasticity
25. The jellyfish green fluorescent protein: A new tool for studying ion channel expression and function
26. 2+ of NMDA responses in spinal cord neurones
27. Physiological and pathophysiological roles of excitatory amino acids during central nervous system development
28. Identification of an intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95
29. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia
30. Structure and function of the NMDA receptor channel
31. Role of the carboxy-terminal region of the GluR epsilon2 sub-unit in synaptic localization of the NMDA receptor channel
32. Molecular diversity of glutamate receptors and implications for brain function
33. Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism
34. Calcium hyperexcitability in neurons cultured with glutamate receptor blockade
35. Activity regulates the synaptic localization of the NMDA receptor in hippocampal neurons
36. Excitotoxicity and the NMDA receptor-still lethal after eight years
37. Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein
38. The Trends Neurosci/TiPS Lecture. The molecular biology of mammalian glutamate receptor channels
39. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport
40. Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation
41. An intramolecular interaction between Src homology 3 domain and guanylate kinaselike domain required for channel clustering by postsynaptic density-95/SAP90
42. C-Terminal truncation of NR2A subunits impairs synaptic but not extrasynaptic localization of NMDA receptors
43. Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-Md-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies
44. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
45. Homeostatic plasticity in neuronal networks: The more things change, the more they stay the same
46. Activity-dependent scaling of quantal amplitude in neocortical neurons
47. Brain spectrin binding to the NMDA receptor is regulated by phosphorylation, calcium and calmodulin
48. Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex
49. Competitive binding of alpha-actin and calmodulin to the NMDA receptor
50. 2+/CaM-activated phosphodiesterases: Expression and physiological functions