Development of a new Ca2+/calmodulin antagonist and its anti-proliferative activity against colorectal cancer cells

Biochemical and Biophysical Research Communications

Volumn 359, Issue 3, 2007, Pages 747-751

  Shim, Joong Sup ^a   Lee, Jiyong ^a   Kim, Kyung Noo ^a   Kwon, Ho Jeong ^a  

^a Seoul National University   (South Korea)

Author keywords

Antagonist; Ca2+ calmodulin; Colorectal cancer cells; Small molecule

Indexed keywords

[4 [3,5 BIS[2 (4 HYDROXY 3 METHOXYPHENYL)VINYL] 4,5 DIHYDROPYRAZOL 1 YL]PHENYL] (4 METHYLPIPERAZIN 1 YL)METHANONE; CALMODULIN INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 1; UNCLASSIFIED DRUG; (4 (3,5 BIS (2 (4 HYDROXY 3 METHOXY PHENYL)VINYL) 4,5 DIHYDRO PYRAZOL 1 YL) PHENYL) (4 METHYL PIPERAZIN 1 YL)METHANONE; (4-(3,5-BIS-(2-(4-HYDROXY-3-METHOXY-PHENYL)VINYL)-4,5-DIHYDRO-PYRAZOL-1-YL)-PHENYL)-(4-METHYL-PIPERAZIN-1-YL)METHANONE; CALCIUM; CALMODULIN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PIPERAZINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; COLORECTAL TUMOR; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

CALCIUM; CALMODULIN; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PIPERAZINES; SIGNAL TRANSDUCTION;

EID: 34250208088     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.05.174     Document Type: Article

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