Carbogen breathing increases prostate cancer oxygenation: A translational MRI study in murine xenografts and humans

British Journal of Cancer

Volumn 100, Issue 4, 2009, Pages 644-648

  Alonzi, R ^a   Padhani, A R ^a   Maxwell, R J ^b   Taylor, N J ^a   Stirling, J J ^a   Wilson, J I ^b   D'Arcy, J A ^c   Collins, D J ^c   Saunders, M I ^a   Hoskin, P J ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

BOLD; Carbogen; Hypoxia; Magnetic resonance imaging; Prostate cancer

Indexed keywords

CARBOGEN;

ADULT; AGED; ANIMAL EXPERIMENT; ARTICLE; CANCER RADIOTHERAPY; CANCER SUSCEPTIBILITY; CLINICAL ARTICLE; CONTROLLED STUDY; GAS; HUMAN; HUMAN CELL; HYPOXIA; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN BREATHING; OXYGENATION; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATECTOMY; RADIOSENSITIVITY; XENOGRAFT;

AGED; ANIMALS; CARBON DIOXIDE; CELL HYPOXIA; CELL LINE, TUMOR; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MICE; MIDDLE AGED; NEOPLASM TRANSPLANTATION; OXYGEN; OXYGEN INHALATION THERAPY; PROSTATIC NEOPLASMS; TRANSPLANTATION, HETEROLOGOUS;

EID: 60349110710     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604903     Document Type: Article

References (33)

1. Al-Hallaq HA, River JN, Zamora M, Oikawa H, Karczmar GS (1998) Correlation of magnetic resonance and oxygen microelectrode measurements of carbogen-induced changes in tumor oxygenation. Int J Radiat Oncol Biol Phys 41: 151-159
2. Alonzi R, Hoskin P (2006) Functional imaging in clinical oncology: magnetic resonance imaging- and computerised tomography-based techniques. Clin Oncol (R Coll Radiol) 18: 555-570
3. Alonzi R, Padhani AR, Taylor NJ, Stirling JJ, Wilton B, d'Arcy JA, Collins DJ, Saunders MI, Hoskin PJ (2008) Sensitivity and specificity of functional MRI to map tumour hypoxia in the human prostate gland. Proc ISMRM. 16th Annual Meeting (Toronto, Canada): program number 167
4. Bland JM, Altman DG (1996a) Measurement error and correlation coefficients. BMJ 313: 41-42
5. Bland JM, Altman DG (1996b) Measurement error proportional to the mean. BMJ 313: 106
6. Bland JM, Altman DG (1996c) Measurement error. BMJ 313: 744
7. Blockley NP, Jiang L, Gardener AG, Ludman CN, Francis ST, Gowland PA (2008) Field strength dependence of R1 and R2* relaxivities of human whole blood to ProHance, Vasovist, and deoxyhemoglobin. Magn Reson Med 60: 1313-1320
8. Brizel DM, Dodge RK, Clough RW, Dewhirst MW (1999) Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome. Radiother Oncol 53: 113-117
9. Falk SJ, Ward R, Bleehen NM (1992) The influence of carbogen breathing on tumour tissue oxygenation in man evaluated by computerised p02 histography. Br J Cancer 66: 919-924
10. Fyles AW, Milosevic M, Wong R, Kavanagh MC, Pintilie M, Sun A, Chapman W, Levin W, Manchul L, Keane TJ, Hill RP (1998) Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol 48: 149-156
11. Gray LH, Conger AD, Ebert M, Hornsey S, Scott OC (1953) The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 26: 638-648
12. Hill SA, Collingridge DR, Vojnovic B, Chaplin DJ (1998) Tumour radiosensitization by high-oxygen-content gases: influence of the carbon dioxide content of the inspired gas on PO2, microcirculatory function and radiosensitivity. Int J Radiat Oncol Biol Phys 40: 943-951
13. Hoskin PJ, Sibtain A, Daley FM, Wilson GD (2003) GLUT1 and CAIX as intrinsic markers of hypoxia in bladder cancer: relationship with vascularity and proliferation as predictors of outcome of ARCON. Br J Cancer 89: 1290-1297
14. Howe FA, Robinson SP, Rodrigues LM, Griffiths JR (1999) Flow and oxygenation dependent (FLOOD) contrast MR imaging to monitor the response of rat tumors to carbogen breathing. Magn Reson Imaging 17: 1307-1318
15. Kaighn ME, Narayan KS, Ohnuki Y, Lechner JF, Jones LW (1979) Establishment and characterization of a human prostatic carcinoma cell line (PC-3). Invest Urol 17: 16-23
16. McSheehy PM, Robinson SP, Ojugo AS, Aboagye EO, Cannell MB, Leach MO, Judson IR, Griffiths JR (1998) Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumors: a magnetic resonance study in vivo. Cancer Res 58: 1185-1194
17. Mickey DD, Stone KR, Wunderli H, Mickey GH, Vollmer RT, Paulson DF (1977) Heterotransplantation of a human prostatic adenocarcinoma cell line in nude mice. Cancer Res 37: 4049-4058
18. Movsas B, Chapman JD, Hanlon AL, Horwitz EM, Greenberg RE, Stobbe C, Hanks GE, Pollack A (2002) Hypoxic prostate/muscle pO2 ratio predicts for biochemical failure in patients with prostate cancer: preliminary findings. Urology 60: 634-639
19. Movsas B, Chapman JD, Horwitz EM, Pinover WH, Greenberg RE, Hanlon AL, Iyer R, Hanks GE (1999) Hypoxic regions exist in human prostate carcinoma. Urology 53: 11-18
20. Nordsmark M, Overgaard M, Overgaard J (1996) Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 41: 31-39
21. Overgaard J, Horsman MR (1996) Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers. Semin Radiat Oncol 6: 10-21
22. Parker C, Milosevic M, Toi A, Sweet J, Panzarella T, Bristow R, Catton C, Catton P, Crook J, Gospodarowicz M, McLean M, Warde P, Hill RP (2004) Polarographic electrode study of tumor oxygenation in clinically localized prostate cancer. Int J Radiat Oncol Biol Phys 58: 750-757
23. Powell ME, Collingridge DR, Saunders MI, Hoskin PJ, Hill SA, Chaplin DJ (1999) Improvement in human tumour oxygenation with carbogen of varying carbon dioxide concentrations. Radiother Oncol 50: 167-171
24. Rijpkema M, Kaanders JH, Joosten FB, van der Kogel AJ, Heerschap A (2002) Effects of breathing a hyperoxic hypercapnic gas mixture on blood oxygenation and vascularity of head-and-neck tumors as measured by magnetic resonance imaging. Int J Radiat Oncol Biol Phys 53: 1185-1191
25. Robinson SP, Collingridge DR, Howe FA, Rodrigues LM, Chaplin DJ, Griffiths JR (1999) Tumour response to hypercapnia and hyperoxia monitored by FLOOD magnetic resonance imaging. NMR Biomed 12: 98-106
26. Robinson SP, Rijken PF, Howe FA, McSheehy PM, van der Sanden BP, Heerschap A, Stubbs M, van der Kogel AJ, Griffiths JR (2003) Tumor vascular architecture and function evaluated by non-invasive susceptibility MRI methods and immunohistochemistry. J Magn Reson Imaging 17: 445-454
27. Robinson SP, Rodrigues LM, Ojugo AS, McSheehy PM, Howe FA, Griffiths JR (1997) The response to carbogen breathing in experimental tumour models monitored by gradient-recalled echo magnetic resonance imaging. Br J Cancer 75: 1000-1006
28. Sibtain A, Hill S, Goodchild K, Shah N, Saunders M, Hoskin PJ (2002) The modification of human tumour blood flow using pentoxifylline, nicotinamide and carbogen. Radiother Oncol 62: 69-76
29. Stone KR, Mickey DD, Wunderli H, Mickey GH, Paulson DF (1978) Isolation of a human prostate carcinoma cell line (DU 145). Int J Cancer 21: 274-281
30. Taylor NJ, Baddeley H, Goodchild KA, Powell ME, Thoumine M, Culver LA, Stirling JJ, Saunders MI, Hoskin PJ, Phillips H, Padhani AR, Griffiths JR (2001) BOLD MRI of human tumor oxygenation during carbogen breathing. J Magn Reson Imaging 14: 156-163
31. Teicher BA, Schwartz GN, Dupuis NP, Kusomoto T, Liu M, Liu F, Northey D (1994) Oxygenation of human tumor xenografts in nude mice by a perfluorochemical emulsion and carbogen breathing. Artif Cells Blood Substit Immobil Biotechnol 22: 1369-1375
32. Tomlinson R, Gray L (1955) The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 9: 539-549
33. Wang JZ, Li XA, Mayr NA (2006) Dose escalation to combat hypoxia in prostate cancer: a radiobiological study on clinical data. Br J Radiol 79: 905-911