Field strength dependence of R1 and R2* relaxivities of human whole blood to ProHance, vasovist, and deoxyhemoglobin

Magnetic Resonance in Medicine

Volumn 60, Issue 6, 2008, Pages 1313-1320

  Blockley, Nicholas P ^a   Jiang, L ^a   Gardener, A G ^a   Ludman, C N ^b   Francis, S T ^a   Gowland, P A ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

Blood; BOLD; Contrast agents; Hematocrit; Oxygenation; Relaxivity

Indexed keywords

MONTE CARLO METHODS; OXYGENATION;

BOLD; CONTRAST AGENT; DEOXYHEMOGLOBIN; FIELD STRENGTHS; HEMATOCRIT; PARABOLIC DEPENDENCE; QUADRATIC DEPENDENCE; RELAXIVITY;

BLOOD;

CONTRAST MEDIUM; DEOXYHEMOGLOBIN; GADOFOSVESET;

ARTICLE; BLOOD; BLOOD OXYGENATION; CONTROLLED STUDY; ERYTHROCYTE; HEMATOCRIT; HUMAN; IN VIVO STUDY; MONTE CARLO METHOD;

EID: 57149096877     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.21792     Document Type: Article

References (25)

1. Lu HZ, Golay X, Pekar JJ, van Zijl PCM. Functional magnetic resonance imaging based on changes in vascular space occupancy. Magn Reson Med 2003;50:263-274.
2. Thulborn KR, Waterton JC, Matthews PM, Radda GK. Oygenation dependence of the transverse relaxation time of water protons in whole blood at high field. Biochim Biophys Acta 1982;714:265-270.
3. Bryant RG, Marill K, Blackmore C, Francis C. Magnetic relaxation in blood and blood clots. Magn Reson Med 1990;13:133-144.
4. Gomori JM, Grossman RI, Yu-Ip C, Asakura T. NMR relaxation times of blood: dependence on field strength, oxidation state, and cell integrity. J Comput Assist Tomogr 1987;11:684-690.
5. Silvennoinen MJ, Clingman CS, Golay X, Kauppinen RA, van Zijl PC. Comparison of the dependence of blood R2 and R2* on oxygen saturation at 1.5 and 4.7 Tesla. Magn Reson Med 2003;49:47-60.
6. Brooks RA, Di Chiro G. Magnetic resonance imaging of stationary blood: a review. Med Phys 1987;14:903-913.
7. Atalay MK, Reeder SB, Zerhouni EA, Forder JR. Blood oxygenation dependence of T1 and T2 in the isolated, perfused rabbit heart at 4.7 T. Magn Reson Med 1995;34:623-627.
8. Barth M, Moser E. Proton NMR relaxation times of human blood samples at 1.5 T and implications for functional MRI. Cell Mol Biol 1997;43:783-791.
9. Spees WM, Yablonskiy DA, Oswood MC, Ackerman JJH. Water proton MR properties of human blood at 1.5 Tesla: magnetic susceptibility, T1, T2, T2*, and non-Lorentzian signal behaviour. Magn Reson Med 2001;45:533-542.
10. Stanisz GJ, Li JG, Wright GA, Henkelman RM. Water dynamics in human blood via combined measurements of T2 relaxation and diffusion in the presence of gadolinium. Magn Reson Med 1998;39:223-233.
11. Koenig SH, Spiller M, Brown RD, Wolf GL. Relaxation of water protons in the intra- and extracellular regions of blood containing Gd(DTPA). Magn Reson Med 1986;3:791-795.
12. Gardener AG, Gowland PA, Francis ST. Measuring the venous blood volume and oxygenation, and changes on activation using CPMG EPI T2 measurements. In: Proceedings of the Annual Meeting of ISMRM, Miami, Florida, USA, 2005. (abstract 1419).
13. Chu SC-K, Xu Y, Balschi JA, Springer CS. Bulk magnetic susceptibility shifts in NMR studies of compartmentalized samples: use of paramagnetic reagents. Magn Reson Med 1990;13:239-262.
14. Dahnke H, Schaeffter T. Limits of detection of SPIO at 3.0 T using T2* relaxometry. Magn Reson Med 2005;53:1202-1206.
15. Fossheim S, Johansson C, Fahlvik AK, Grace D, Klaveness J. Lanthanide-based susceptibility contrast agents: assessment of the magnetic properties. Magn Reson Med 1996;35:201-206.
16. Weisskoff RM, Chun SZ, Boxerman JL, Rosen BR. Microscopic susceptibility variation and transverse relaxation: theory and experiment. Magn Reson Med 1994;31:601-610.
17. Gillis P, Petö S, Moiny F, Mispelter J, Cuenod C-A. Proton transverse nuclear magnetic relaxation in oxidised blood: a numerical approach. Magn Reson Med 1995;33:93-100.
18. Lo Bue F, Moiny F, Gillis P. Magnetic resonance susceptibility contrast induced by capillaries: a numerical comparison of two models. MAGMA 1997;5:39-44.
19. Kokholm G. Simultaneous measurement of blood pH, pCO2, pO2 and concentrations of haemoglobin and its derivatives - a multicenter study. Scand J Clin Lab Invest 1990;50:S75-S86.
20. Silvennoinen MJ, Kettunen MI, Kauppinen RA. Effects of hematocrit and oxygen saturation level on spin-lattice relaxation. Magn Reson Med 2003;49:568-571.
21. Koenig SH, Brown RD. Field-cycling relaxometry of protein solutions and tissue: implications for MRI. Prog Nucl Magen Reson Spectrosc 1990;22:487-567.
22. Tóth E, Helm L, Merbach AE. Relaxivity of MRI contrast agents. Top Curr Chem 2002;221:61-101.
23. Rohrer M, Bauer H, Mintorovitch J, Requardt M, Weinmann HJ. Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths. Invest Radiol 2005;40:715-724.
24. Li D, Waight DJ. In vivo correlation between blood T2* and oxygen saturation. J Magn Reson Imaging 1998;87:1236-1239.
25. Shuter B, Wang SC, Roche J, Briggs G, Pope JM. Relaxivity of Gd-EOB-DTPA in the normal and biliary obstructed guinea pig. J Magn Reson Imaging 1998;8:853-861.