Improvement in human tumour oxygenation with carbogen of varying carbon dioxide concentrations

Radiotherapy and Oncology

Volumn 50, Issue 2, 1999, Pages 167-171

  Powell, Melanie E B ^a   Collingridge, David R ^b   Saunders, Michele I ^a   Hoskin, Peter J ^a   Hill, Sally A ^b   Chaplin, David J ^b  

^a CRC Tum Biol and Radiat Res Grp   (United Kingdom)

^b Gray Laboratory Cancer Research Trust   (United Kingdom)

Author keywords

Carbogen; Eppendorf pO2histograph; Human tumour oxygenation

Indexed keywords

CARBOGEN; CARBON DIOXIDE; OXYGEN;

ARTICLE; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; GAS ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXEMIA; MALE; OXYGEN TENSION; OXYGENATION; PRIORITY JOURNAL; RADIOSENSITIZATION; TREATMENT OUTCOME;

ADMINISTRATION, INHALATION; CARBON DIOXIDE; FEMALE; HUMANS; MALE; NEOPLASMS; OXYGEN; RADIATION-SENSITIZING AGENTS; TREATMENT OUTCOME;

EID: 0032949498     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(98)00123-6     Document Type: Article

References (21)

1. Argyll Campbell J. The use of gas mixtures in cancer therapy. Cancer Rev. 6:1931;289-302.
2. Fischer-Wasels B. Frankfurter Zeitschrift fur Pathologie. 1930;J.F. Bergmann, Munich.
3. Thomlinson R.H., Gray L.H. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J. Cancer. 9:1955;539-549.
4. Keresteci A.G., Rider W.D. Use of orthobaric oxygen in the radiotherapy of bladder tumours. Can. J. Surg. 16:1978;127-129.
5. Rubin P., Hanley J., Keys H.M., Marcial V., Brady L. Carbogen breathing during radiation therapy-the Radiation Therapy Oncology Group Study. Int. J. Radiat. Oncol. Biol. Phys. 5:1979;1963-1970.
6. Siemann D.W., Hill R.P., Bush R.S. The importance of the pre-irradiation breathing times of oxygen and carbogen (5% CO2:95% O2) on the in vivo radiation response of a murine sarcoma. Int. J. Radiat. Oncol. Biol. Phys. 2:1977;903-911.
7. Falk S.J., Ward R., Bleehen N.M. The influence of carbogen breathing on tumour tissue oxygenation in man evaluated by computerised po2 histography. Br. J. Cancer. 66:1992;919-924.
8. Chaplin D.J., Horsman M.R., Siemann D.W. Further evaluation of nicotinamide and carbogen as a strategy to reoxygenate hypoxic cells in vivo: importance of nicotinamide dose and pre-irradiation breathing time. Br. J. Cancer. 68:1993;269-273.
9. Hoskin P.J., Saunders M.I., Phillips H., et al. Carbogen and nicotinamide in the treatment of bladder cancer with radical radiotherapy. Br. J. Cancer. 76:1997;260-263.
10. Rodrigues L.M., Maxwell R.J., McSheehy P.M.J., et al. In vivo detection of ifosfamide by 31P-MRS in rat tumours: increased uptake and cytotoxicity induced by carbogen breathing in GH3 prolactinomas. Br. J. Cancer. 75:1997;62-68.
11. Hoskin P, Abdelath O, Phillips H, et al. Inspired and expired gas concentrations in man during carbogen breathing, submitted.
12. Bean J. Effects of oxygen at increased pressure. Physiol. Rev. 25:1945;16-18.
13. Hill S.A., Collingridge D.R., Vojnovic B., Chaplin D.J. Tumour radiosensitization by high oxygen content gases: influence of the carbon dioxide content of the inspired on po2 microcirculatory function and radiosensitivity. Int. J. Radiat. Oncol. 40:1998;943-951.
14. Dische S., Rojas A., Rugg T., Hong A., Michael B.D. Carbogen breathing: a system for use in man. Br. J. Radiol. 65:1992;87-90.
15. Kallinowski F., Zander R., Hockel M., Vaupel P. Tumour tissue oxygenation as evaluated by computerized po2 histography. Int. J. Radiat. Oncol. Biol. Phys. 19:1990;953-961.
16. Vaupel P., Schlenger K., Knoop C., Hoeckel M. Oxygenation of human tumours: evaluation of tissue oxygen distribution in breast cancers by computerised O2 tension measurements. Cancer Res. 51:1991;3316-3322.
17. Martin L., Lartigau E., Weeger P., et al. Changes in the oxygenation of head and neck tumors during carbogen breathing. Radiother. Oncol. 27:1993;123-130.
18. Nordsmark M., Bentzen S.M., Overgaard J. Measurement of human tumour oxygenation status by polargraphic needle electrode. Acta Oncol. 33:1994;383-389.
19. Robinson S.P., Howe F.A., Griffiths J.R. Non-invasive monitoring of carbogen-induced changes in tumour blood flow and oxygenation by functional magnetic resonance imaging. Int. J. Radiat. Oncol. Biol. Phys. 33:1995;855-859.
20. Hill S.A., Pigott K.H., Saunders M.I., et al. Microregional blood flow fluctuations in murine and human tumours assessed using laser Doppler microprobes. Br. J. Cancer. 74:1996;260-263.
21. Powell M.E.B., Hill S.A., Saunders M.I., Hoskin P.J., Chaplin D.J. Effect of carbogen breathing on tumour microregional blood flow in humans. Radiother. Oncol. 41:1996;225-231.