5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus

Neuroscience

Volumn 159, Issue 1, 2009, Pages 83-93

  Hisadome, K ^a   Smith, M A ^a,b   Choudhury, A I ^b   Claret, M ^b   Withers, D J ^b   Ashford, M L J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

5 HT; 5 HT1F receptor; hypothalamus; K+ channel; POMC; RIPCre

Indexed keywords

CRE RECOMBINASE; GREEN FLUORESCENT PROTEIN; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; PROOPIOMELANOCORTIN; SEROTONIN; SEROTONIN 1F RECEPTOR; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARCUATE NUCLEUS; ARTICLE; BRAIN NERVE CELL; CELL ACTIVATION; DEPOLARIZATION; ELECTRIC CURRENT; ENERGY BALANCE; HYPERPOLARIZATION; HYPOTHALAMUS; IMMUNOREACTIVITY; INHIBITION KINETICS; MEMBRANE STEADY POTENTIAL; MOUSE; NERVE CELL NETWORK; NEUROMODULATION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SYNAPTIC TRANSMISSION; TRANSGENE;

ACTION POTENTIALS; AGOUTI-RELATED PROTEIN; ANIMALS; ARCUATE NUCLEUS; BIOPHYSICAL PROCESSES; ELECTRIC STIMULATION; GREEN FLUORESCENT PROTEINS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INTEGRASES; MICE; MICE, TRANSGENIC; NEURAL INHIBITION; NEURONS; NEUROPEPTIDE Y; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; PRO-OPIOMELANOCORTIN; SEROTONIN; SEROTONIN ANTAGONISTS; TIME FACTORS;

EID: 60349088591     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2008.12.003     Document Type: Article

References (44)

1. Acuna-Castillo C., Villalobos C., Moya P.R., Saez P., Cassels B.K., and Huidobro-Toro J.P. Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT(2A) and 5-HT(2C) receptors. Br J Pharmacol 136 (2002) 510-519
2. Adham N., Borden L.A., Schechter L.E., Gustafson E.L., Cochran T.L., Vaysse P.J., Weinshank R.L., and Branchek T.A. Cell-specific coupling of the cloned human 5-HT1F receptor to multiple signal transduction pathways. Arch Pharmacol 348 (1993) 566-575
3. Bai F., Yin T., Johnstone E.M., Su C., Varga G., Little S.P., and Nelson D.L. Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol 484 (2004) 127-139
4. Baxter G., Kennett G., Blaney F., and Blackburn T. 5-HT2 receptor subtypes: a family re-united?. Trends Pharmacol Sci 16 (1995) 105-110
5. Beer M.S., Stanton J.A., Bevan Y., Heald A., Reeve A.J., Street L.J., Matassa V.G., Hargreaves R.J., and Middlemiss D.N. L-694,247: a potent 5-HT1D receptor agonist. Br J Pharmacol 110 (1993) 1196-1200
6. Bonnin A., Peng W., Hewlett W., and Levitt P. Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development. Neuroscience 141 (2006) 781-794
7. Broberger C. Brain regulation of food intake and appetite: molecules and networks. J Intern Med 258 (2005) 301-327
8. Brown A.M., Avenell K., Young T.J., Ho M., Porter R.A., Vimal M., and Middlemiss D.N. BRL 54443, a potent agonist with selectivity for cloned 5-HT1E and 5-HT1F receptors. Br J Pharmacol 123 (1998) 233P
9. Choudhury A.I., Heffron H., Smith M.A., Al-Qassab H., Xu A.W., Selman C., Simmgen M., Clements M., Claret M., MacColl G., Bedford D.C., Hisadome K., Diakonov I., Moosajee V., Bell J.D., Speakman J.R., Batterham R.L., Barsh G.S., Ashford M.L.J., and Withers D.J. The role of insulin receptor substrate 2 in hypothalamic and β cell function. J Clin Invest 115 (2005) 940-950
10. Claret M., Smith M.A., Batterham R.L., Selman C., Choudhury A.I., Fryer L.G.D., Clements M., Al-Qassab H., Heffron H., Xu A.W., Speakman J.R., Barsh G.S., Viollet B., Vaulont S., Ashford M.L.J., Carling D., and Withers D.J. AMPK is essential for energy homeostasis regulation and glucose-sensing by POMC and AgRP neurons. J Clin Invest 117 (2007) 2325-2336
11. Clemett D.A., Punhani T., Duxon M.S., Blackburn T.P., and Fone K.C. Immunohistochemical localization of the 5-HT2C receptor protein in the rat CNS. Neuropharmacology 39 (2000) 123-132
12. Cone R.D. Anatomy and regulation of the central melanocortin system. Nat Neurosci 8 (2005) 571-578
13. Cowley M.A., Smart J.L., Rubinstein M., Cerdán M.G., Diano S., Horvath T.L., Cone R.D., and Low M.J. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411 (2001) 480-484
14. Cui Y., Huang L., Elefteriou F., Yang G., Shelton J.M., Giles J.E., Oz O.K., Pourbahrami T., Lu C.Y.H., Richardson J.A., Karsenty G., and Li C. Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol 24 (2004) 258-269
15. Ellacott K.L., and Cone R.D. The central melanocortin system and the integration of short- and long-term regulators of energy homeostasis. Recent Prog Horm Res 59 (2004) 395-408
16. Halford J.C., Harrold J.A., Lawton C.L., and Blundell J.E. Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr Drug Targets 6 (2005) 201-213
17. Hansen H.H., Waroux O., Seutin V., Jentsch T.J., Aznar S., and Mikkelsen J.D. Kv7 channels: interaction with dopaminergic and serotonergic neurotransmission in the CNS. J Physiol 586 (2008) 1823-1832
18. Heisler L.K., Cowley M.A., Tecott L.H., Ran W., Low M.J., Smart J.L., Rubinstein M., Tatro J.B., Marcus J.N., Holstege H., Lee C.E., Cone R.D., and Elmquist J.K. Activation of central melanocortin pathways by fenfluramine. Science 297 (2002) 609-611
19. Heisler L.K., Jobst E.E., Sutton G.M., Zhou L., Borok E., Thornton-Jones Z., Liu H.Y., Zigman J.M., Balthasar N., Kishi T., Lee C.E., Aschkenasi C.J., Zhang C.Y., Yu J., Boss O., Mountjoy K.G., Clifton P.G., Lowell B.B., Friedman J.M., Horvath T., Butler A.A., Elmquist J.K., and Cowley M.A. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron 51 (2006) 239-249
20. Hoyer D., Hannon J.P., and Martin G.R. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 71 (2002) 533-554
21. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., Saxena P.R., and Humphrey P.P. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev 46 (1994) 157-203
22. Ioannides-Demos L.L., Proietto J., and McNeil J.J. Pharmacotherapy for obesity. Drugs 65 (2005) 1391-1418
23. + current mediated by 5-HT1A receptor in the acutely dissociated rat dorsal raphe neurons. Brain Res 745 (1997) 283-292
24. Kennett G.A., Ainsworth K., Trail B., and Blackburn T.P. BW 732C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats. Neuropharmacology 36 (1997) 233-239
25. Kennett G.A., Wood M.D., Bright F., Trail B., Riley G., Holland V., Avenell K.Y., Stean T., Upton N., Bromidge S., Forbes I.T., Brown A.M., Middlemiss D.N., and Blackburn T.P. SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology 36 (1997) 609-620
26. Kilpatrick G.J., Butler A., Burridge J., and Oxford A.W. 1-(M-chlorophenyl)-biguanide, a potent high affinity 5-HT3 receptor agonist. Eur J Pharmacol 182 (1990) 193-197
27. Könner A.C., Janoschek R., Plum L., Jordan S.D., Rother E., Ma X., Xu C., Enriori P., Hampel B., Barsh G.S., Khan C.R., Cowley M.A., Ashcroft F.M., and Brüning J.C. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab 5 (2007) 348-449
28. Lovenberg T.W., Erlander M.G., Baron B.M., Racke M., Slone A.L., Siegel B.W., Craft C.M., Burns J.E., Danielson P.E., and Sutcliffe J.G. Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes. Proc Natl Acad Sci U S A 90 (1993) 2184-2188
29. Lucas J.J., Yamamoto A., Scearce-Levie K., Saudou F., and Hen R. Absence of fenfluramine-induced anorexia and reduced c-fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice. J Neurosci 18 (1998) 5537-5544
30. Makarenko I.G., Meguid M.M., and Ugrumov M.V. Distribution of serotonin 5-hydroxytriptamine 1B (5HT(1B)) receptors in the normal rat hypothalamus. Neurosci Lett 328 (2002) 155-159
31. 1A receptor. J Neurosci 24 (2004) 7159-7166
32. Niswender K.D., Baskin D.G., and Schwartz M.W. Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis. Trends Endocrinol Metab 15 (2004) 362-369
33. Peters J.A., Malone H.M., and Lambert J.J. Recent advances in the electrophysiological characterization of 5-HT3 receptors. Trends Pharmacol Sci 13 (1992) 391-397
34. ATP channel activation and leads to diet-sensitive obesity. J Clin Invest 116 (2006) 1886-1901
35. Ramboz S., Saudou F., Amara D.A., Belzung C., Segu L., Misslin R., Buhot M.C., and Hen R. 5-HT1B receptor knock out: behavioural consequences. Behav Brain Res 73 (1996) 305-312
36. Ramos E.J.B., Meguid M.M., Campos A.C.L., and Coelho J.C.U. Neuropeptide Y, α-melanocyte-stimulating hormone, and monoamines in food intake regulation. Nutrition 21 (2005) 269-279
37. Raymond J.R., Mukhin Y.V., Gelasco A., Turner J., Collinsworth G., Gettys T.W., Grewal J.S., and Garnovskaya M.N. Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacol Ther 92 (2001) 179-212
38. Roseberry A.G., Liu H., Jackson A.C., Cai X., and Friedman J.M. Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron 41 (2004) 711-722
39. Schiavi G.B., Brunet S., Rizzi C.A., and Ladinsky H. Identification of serotonin 5-HT4 recognition sites in the porcine caudate nucleus by radioligand binding. Neuropharmacology 33 (1994) 543-549
40. Schwartz D.H., Hernandez L., and Hoebel B.G. Serotonin release in lateral and medial hypothalamus during feeding and its anticipation. Brain Res Bull 25 (1990) 797-802
41. Selkirk J.V., Scott C., Ho M., Burton M.J., Watson J., Gaster L.M., Collin L., Jones B.J., Middlemiss D.N., and Price G.W. SB-224289: a novel selective (human) 5-HT1B receptor antagonist with negative intrinsic activity. Br J Pharmacol 125 (1998) 202-208
42. Smith M.A., Hisadome K., Al-Qassab H., Heffron H., Withers D.J., and Ashford M.L.J. Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration excitability by alteration of resting potassium conductances. J Physiol 578 (2007) 425-438
43. Tecott L.H., Sun L.M., Akana S.F., Strack A.M., Lowenstein D.H., Dallman M.F., and Julius D. Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 374 (1995) 542-546
44. Tiligada E., and Wilson J.F. Regulation of alpha-melanocyte-stimulating hormone release from superfused slices of rat hypothalamus by serotonin and the interaction of serotonin with the dopaminergic system inhibiting peptide release. Brain Res 503 (1989) 225-228