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Volumn 301, Issue 1-2, 2009, Pages 183-190

Reductive 17β-hydroxysteroid dehydrogenases in the sulfatase pathway: Critical in the cell proliferation of breast cancer

Author keywords

17 HSD1 inhibitors; Aromatase pathway; Breast cancer cell xenografts; Breast cancer cells; Reductive 17 hydroxysteroid dehydrogenases; Sulfatase pathway

Indexed keywords

AROMATASE; ESTROGEN; SULFATASE; TESTOSTERONE 17BETA DEHYDROGENASE; 3 (OR 17) BETA HYDROXYSTEROID DEHYDROGENASE; 3 (OR 17)-BETA-HYDROXYSTEROID DEHYDROGENASE; HYDROXYSTEROID DEHYDROGENASE;

EID: 60249089307     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.10.042     Document Type: Review
Times cited : (42)

References (71)
  • 2
    • 1542329058 scopus 로고    scopus 로고
    • The proliferative effects of 5-androstene-3 beta,17 beta-diol and 5 alpha-dihydrotestosterone on cell cycle analysis and cell proliferation in MCF-7, T47D and MDAMB231 breast cancer cell lines
    • Aspinall S.R., Stamp S., Davison A., Shenton B.K., and Lennard T.W. The proliferative effects of 5-androstene-3 beta,17 beta-diol and 5 alpha-dihydrotestosterone on cell cycle analysis and cell proliferation in MCF-7, T47D and MDAMB231 breast cancer cell lines. J. Steroid Biochem. Mol. Biol. 88 (2004) 37-51
    • (2004) J. Steroid Biochem. Mol. Biol. , vol.88 , pp. 37-51
    • Aspinall, S.R.1    Stamp, S.2    Davison, A.3    Shenton, B.K.4    Lennard, T.W.5
  • 3
    • 11444251764 scopus 로고    scopus 로고
    • Results of the ATAC (Arimidex, Tamoxifen, alone or in combination) trial after completion of 5 years' adjuvant treatment for breast cancer
    • ATAC Trialists Group. Results of the ATAC (Arimidex, Tamoxifen, alone or in combination) trial after completion of 5 years' adjuvant treatment for breast cancer. The Lancet 365 (2005) 60-62
    • (2005) The Lancet , vol.365 , pp. 60-62
    • ATAC Trialists Group1
  • 4
    • 37449028688 scopus 로고    scopus 로고
    • Effect of anastrozol and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial
    • ATAC Trialists Group. Effect of anastrozol and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial. Lancet Oncol. 9 (2008) 45-53
    • (2008) Lancet Oncol. , vol.9 , pp. 45-53
    • ATAC Trialists Group1
  • 5
    • 0029761692 scopus 로고    scopus 로고
    • Crystal structure of human estrogenic 17beta-hydroxysteroid dehydrogenase complexed with 17beta-estradiol
    • Azzi A., Rehse P.H., Zhu D.-W., Campbell R.L., Labrie F., and Lin S.-X. Crystal structure of human estrogenic 17beta-hydroxysteroid dehydrogenase complexed with 17beta-estradiol. Nat. Struct. Biol. 3 (1996) 665-668
    • (1996) Nat. Struct. Biol. , vol.3 , pp. 665-668
    • Azzi, A.1    Rehse, P.H.2    Zhu, D.-W.3    Campbell, R.L.4    Labrie, F.5    Lin, S.-X.6
  • 6
    • 0000138390 scopus 로고    scopus 로고
    • Pharmacology of non-steroidal aromatase inhibitors
    • Pasqualini J.R., and Katzenellenbogen B.S. (Eds), Marcel Dekker, New York
    • Bhatnagar A.S., Batzl C., Häusler A., Schieweck K., Lang M., and Trunet P.F. Pharmacology of non-steroidal aromatase inhibitors. In: Pasqualini J.R., and Katzenellenbogen B.S. (Eds). Hormone-Dependent Cancer (1996), Marcel Dekker, New York 155-168
    • (1996) Hormone-Dependent Cancer , pp. 155-168
    • Bhatnagar, A.S.1    Batzl, C.2    Häusler, A.3    Schieweck, K.4    Lang, M.5    Trunet, P.F.6
  • 8
    • 0035931123 scopus 로고    scopus 로고
    • 17beta-hydroxysteroid dehydrogenase type 7-an ancient 3-ketosteroid reductase of cholesterogenesis
    • Breitling R., Krazeisen G., Möller J., and Adamski J. 17beta-hydroxysteroid dehydrogenase type 7-an ancient 3-ketosteroid reductase of cholesterogenesis. Mol. Cell. Endocrinol. 171 (2001) 199-204
    • (2001) Mol. Cell. Endocrinol. , vol.171 , pp. 199-204
    • Breitling, R.1    Krazeisen, G.2    Möller, J.3    Adamski, J.4
  • 9
    • 0030586820 scopus 로고    scopus 로고
    • The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors
    • Breton R., Housset D., Mazza C., and Fontecilla-Camps J.C. The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors. Structure 4 (1996) 905-915
    • (1996) Structure , vol.4 , pp. 905-915
    • Breton, R.1    Housset, D.2    Mazza, C.3    Fontecilla-Camps, J.C.4
  • 10
    • 60249093220 scopus 로고    scopus 로고
    • Canadian Cancer Society (www.cancer.ca). Breast Cancer Statistics.
    • Canadian Cancer Society (www.cancer.ca). Breast Cancer Statistics.
  • 11
    • 38349057321 scopus 로고    scopus 로고
    • Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts
    • Chung H., Jung Y.M., Shin D.H., Lee J.Y., Oh M.Y., Kim H.J., Jang K.S., Jeon S.J., Son K.H., and Kong G. Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts. Int. J. Cancer 122 (2008) 816-822
    • (2008) Int. J. Cancer , vol.122 , pp. 816-822
    • Chung, H.1    Jung, Y.M.2    Shin, D.H.3    Lee, J.Y.4    Oh, M.Y.5    Kim, H.J.6    Jang, K.S.7    Jeon, S.J.8    Son, K.H.9    Kong, G.10
  • 12
    • 0141919555 scopus 로고    scopus 로고
    • Inhibition of estrone sulfate-induced uterine growth by potent nonestrogenic steroidal inhibitors of steroid sulfatase
    • Ciobanu L.C., Luu-The V., Martel C., Labrie F., and Poirier D. Inhibition of estrone sulfate-induced uterine growth by potent nonestrogenic steroidal inhibitors of steroid sulfatase. Cancer Res. 63 (2003) 6442-6446
    • (2003) Cancer Res. , vol.63 , pp. 6442-6446
    • Ciobanu, L.C.1    Luu-The, V.2    Martel, C.3    Labrie, F.4    Poirier, D.5
  • 13
    • 0027473495 scopus 로고
    • Androgen receptor-mediated stimulation of 17 beta-hydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in ZR-75-1 human breast cancer cells
    • Couture P., Theriault C., Simard J., and Labrie F. Androgen receptor-mediated stimulation of 17 beta-hydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in ZR-75-1 human breast cancer cells. Endocrinology 132 (1993) 179-185
    • (1993) Endocrinology , vol.132 , pp. 179-185
    • Couture, P.1    Theriault, C.2    Simard, J.3    Labrie, F.4
  • 17
    • 41849117998 scopus 로고    scopus 로고
    • Design, Synthesis, and biological evaluation of (hydroxyphenyl) naphthalene and quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1(17beta-HSD1) for the treatment of estrogen-dependent diseases
    • Frotscher M., Ziegler E., Marchais-Oberwinkler S., Kruchten P., Neugebauer A., Fetzer L., Scherer C., Müller-Vieira U., Messinger J., Thole H., and Hartmann R.W. Design, Synthesis, and biological evaluation of (hydroxyphenyl) naphthalene and quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1(17beta-HSD1) for the treatment of estrogen-dependent diseases. J. Med. Chem. 51 (2008) 2158-2169
    • (2008) J. Med. Chem. , vol.51 , pp. 2158-2169
    • Frotscher, M.1    Ziegler, E.2    Marchais-Oberwinkler, S.3    Kruchten, P.4    Neugebauer, A.5    Fetzer, L.6    Scherer, C.7    Müller-Vieira, U.8    Messinger, J.9    Thole, H.10    Hartmann, R.W.11
  • 18
    • 0037317465 scopus 로고    scopus 로고
    • Pseudo-symmetry of C19-steroids, alternative binding orientations, and multispecificity in human estrogenic 17β-hydroxysteroid dehydrogenase
    • Gangloff A., Shi R., Nahoum V., and Lin S.-X. Pseudo-symmetry of C19-steroids, alternative binding orientations, and multispecificity in human estrogenic 17β-hydroxysteroid dehydrogenase. FASEB J. 17 (2003) 274-276
    • (2003) FASEB J. , vol.17 , pp. 274-276
    • Gangloff, A.1    Shi, R.2    Nahoum, V.3    Lin, S.-X.4
  • 20
    • 3042737052 scopus 로고    scopus 로고
    • Inhibition of MCF-7 breast cancer cell proliferation by 5alpha-dihydrotestosterone: a role for p21(Cip1/Waf1)
    • Greeve M.A., Allan R.K., Harvey J.M., and Bentel J.M. Inhibition of MCF-7 breast cancer cell proliferation by 5alpha-dihydrotestosterone: a role for p21(Cip1/Waf1). J Mol Endocrinol 32 (2004) 793-810
    • (2004) J Mol Endocrinol , vol.32 , pp. 793-810
    • Greeve, M.A.1    Allan, R.K.2    Harvey, J.M.3    Bentel, J.M.4
  • 21
    • 15244352525 scopus 로고    scopus 로고
    • 17β-Hydroxysteroid dehydrogenases involved in local oestrogen synthesis have prognostic significance in breast cancer
    • Gunnarsson C., Hellqvist E., and Stål O. 17β-Hydroxysteroid dehydrogenases involved in local oestrogen synthesis have prognostic significance in breast cancer. Brit. J. Cancer 92 (2005) 547-552
    • (2005) Brit. J. Cancer , vol.92 , pp. 547-552
    • Gunnarsson, C.1    Hellqvist, E.2    Stål, O.3
  • 23
    • 0033966934 scopus 로고    scopus 로고
    • Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/C-19 steroid discrimination and enzyme-induced strain
    • Han Q., Campbell R.L., Gangloff A., Huang Y.W., and Lin S.-X. Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/C-19 steroid discrimination and enzyme-induced strain. J. Biol. Chem. 275 (2000) 1105-1111
    • (2000) J. Biol. Chem. , vol.275 , pp. 1105-1111
    • Han, Q.1    Campbell, R.L.2    Gangloff, A.3    Huang, Y.W.4    Lin, S.-X.5
  • 25
    • 0034749467 scopus 로고    scopus 로고
    • Critical residues for the specificity toward NADH or NADPH in human estrogenic 17beta-hydroxysteroid dehydrogenase: site-directed mutagenesis designed from the three-dimensional structure of the enzyme
    • Huang Y.-W., Pineau I., Chang H.-J., Azzi A., Bellemare V., Laberge S., and Lin S.-X. Critical residues for the specificity toward NADH or NADPH in human estrogenic 17beta-hydroxysteroid dehydrogenase: site-directed mutagenesis designed from the three-dimensional structure of the enzyme. Mol. Endocrinol. 15 (2001) 2010-2020
    • (2001) Mol. Endocrinol. , vol.15 , pp. 2010-2020
    • Huang, Y.-W.1    Pineau, I.2    Chang, H.-J.3    Azzi, A.4    Bellemare, V.5    Laberge, S.6    Lin, S.-X.7
  • 26
    • 33751240474 scopus 로고    scopus 로고
    • Human hydroxysteroid (17-beta) dehydrogenase 1 expression enhances estrogen sensitivity of MCF-7 breast cancer cell xenografts
    • Husen B., Huhtinen K., Saloniemi T., Messinger J., Thole H.H., and Poutanen M. Human hydroxysteroid (17-beta) dehydrogenase 1 expression enhances estrogen sensitivity of MCF-7 breast cancer cell xenografts. Endocrinology 147 (2006) 5333-5339
    • (2006) Endocrinology , vol.147 , pp. 5333-5339
    • Husen, B.1    Huhtinen, K.2    Saloniemi, T.3    Messinger, J.4    Thole, H.H.5    Poutanen, M.6
  • 27
    • 0035053009 scopus 로고    scopus 로고
    • Constitutive expression of the steroid sulfatase gene supports the growth of MCF-7 human breast cancer cells in vitro and in vivo
    • James M.R., Skaar T.C., Lee R.Y., MacPherson A., Zwiebel J.A., Ahluwalia B.S., Ampy F., and Clarke R. Constitutive expression of the steroid sulfatase gene supports the growth of MCF-7 human breast cancer cells in vitro and in vivo. Endocrinology 142 (2001) 1497-1505
    • (2001) Endocrinology , vol.142 , pp. 1497-1505
    • James, M.R.1    Skaar, T.C.2    Lee, R.Y.3    MacPherson, A.4    Zwiebel, J.A.5    Ahluwalia, B.S.6    Ampy, F.7    Clarke, R.8
  • 28
    • 0000797162 scopus 로고
    • Soluble 17beta-hydroxysteroid dehydrogenase of human placenta
    • Jarabak J. Soluble 17beta-hydroxysteroid dehydrogenase of human placenta. Methods Enzymol. 15 (1969) 746-752
    • (1969) Methods Enzymol. , vol.15 , pp. 746-752
    • Jarabak, J.1
  • 29
    • 0033532388 scopus 로고    scopus 로고
    • Human estrogenic 17beta-hydroxysteroid deshydrogenase: predominence of estrone reduction and its induction by NADPH
    • Jin J.Z., and Lin S.X. Human estrogenic 17beta-hydroxysteroid deshydrogenase: predominence of estrone reduction and its induction by NADPH. Biochem. Biophys. Res. Commun. 259 (1999) 489-493
    • (1999) Biochem. Biophys. Res. Commun. , vol.259 , pp. 489-493
    • Jin, J.Z.1    Lin, S.X.2
  • 30
    • 0032727093 scopus 로고    scopus 로고
    • Determination of cDNA, gene structure and chromosomal localisation of the novel human 17beta-hydroxysteroid dehydrogenase type 7 (1)
    • Krazeisen A., Breitling R., Imai K., Fritz S., Möller G., and Adamski J. Determination of cDNA, gene structure and chromosomal localisation of the novel human 17beta-hydroxysteroid dehydrogenase type 7 (1). FEBS Lett. 460 (1999) 373-379
    • (1999) FEBS Lett. , vol.460 , pp. 373-379
    • Krazeisen, A.1    Breitling, R.2    Imai, K.3    Fritz, S.4    Möller, G.5    Adamski, J.6
  • 33
    • 38949103729 scopus 로고    scopus 로고
    • Estradiol and estrone C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid deshydrogenase: blocking of ER+ breast cancer cell proliferation induced by estrone
    • Laplante Y., Cadot C., Fournier M.A., and Poirier D. Estradiol and estrone C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid deshydrogenase: blocking of ER+ breast cancer cell proliferation induced by estrone. Bioorg. Med. Chem. 16 (2008) 1849-1860
    • (2008) Bioorg. Med. Chem. , vol.16 , pp. 1849-1860
    • Laplante, Y.1    Cadot, C.2    Fournier, M.A.3    Poirier, D.4
  • 34
    • 0026737624 scopus 로고
    • Subunit identity of the dimeric 17beta-hydroxysteroid dehydrogenase from human placenta
    • Lin S.-X., Yang F., Jin J.-Z., Breton R., Zhu D.-W., Luu-The V., and Labrie F. Subunit identity of the dimeric 17beta-hydroxysteroid dehydrogenase from human placenta. J. Biol. Chem. 267 (1992) 16182-16187
    • (1992) J. Biol. Chem. , vol.267 , pp. 16182-16187
    • Lin, S.-X.1    Yang, F.2    Jin, J.-Z.3    Breton, R.4    Zhu, D.-W.5    Luu-The, V.6    Labrie, F.7
  • 36
    • 0030059217 scopus 로고    scopus 로고
    • Serum steroid hormone levels, sex hormone-binding globulin, and body mass index in the ethiology of postmenopausal breast cancer
    • Lipworth L., Adami H.O., Trichopoulos D., Carlstrom K., and Mantzoros C. Serum steroid hormone levels, sex hormone-binding globulin, and body mass index in the ethiology of postmenopausal breast cancer. Epidemiology 7 (1996) 96-100
    • (1996) Epidemiology , vol.7 , pp. 96-100
    • Lipworth, L.1    Adami, H.O.2    Trichopoulos, D.3    Carlstrom, K.4    Mantzoros, C.5
  • 37
    • 33847154619 scopus 로고    scopus 로고
    • Expression and localization of estrogenic type 12 17beta-hydroxysteroid dehydrogenase in the cynomolgus monkey
    • Liu H., Zheng S., Bellemare V., Pelletier G., Labrie F., and Luu-The V. Expression and localization of estrogenic type 12 17beta-hydroxysteroid dehydrogenase in the cynomolgus monkey. BMC Biochem. 8 (2007) 2
    • (2007) BMC Biochem. , vol.8 , pp. 2
    • Liu, H.1    Zheng, S.2    Bellemare, V.3    Pelletier, G.4    Labrie, F.5    Luu-The, V.6
  • 38
    • 31444432288 scopus 로고    scopus 로고
    • Characterization of type 12 17β-hydroxysteroid dehydrogenase responsible for estradiol formation in women
    • Luu-The V., Tremblay P., and Labrie F. Characterization of type 12 17β-hydroxysteroid dehydrogenase responsible for estradiol formation in women. Mol. Endocrinol. 20 (2006) 437-443
    • (2006) Mol. Endocrinol. , vol.20 , pp. 437-443
    • Luu-The, V.1    Tremblay, P.2    Labrie, F.3
  • 39
    • 0023766839 scopus 로고
    • The hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate by MCF-7 human breast cancer cells
    • MacIndoe J.R., Woods G., Jeffries L., and Hinkhouse M. The hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate by MCF-7 human breast cancer cells. Endocrinology 123 (1988) 1281-1287
    • (1988) Endocrinology , vol.123 , pp. 1281-1287
    • MacIndoe, J.R.1    Woods, G.2    Jeffries, L.3    Hinkhouse, M.4
  • 41
    • 0029670229 scopus 로고    scopus 로고
    • Human 17β-hydroxysteroid dehydrogenase type 1 and type 2 isoenzymes have opposite activities in cultured cells and characteristic cell- and tissue-specific expression
    • Miettinen M.M., Mustonen M.J.V., Poutanen M.H., Isomaa V.V., and Vihko R.K. Human 17β-hydroxysteroid dehydrogenase type 1 and type 2 isoenzymes have opposite activities in cultured cells and characteristic cell- and tissue-specific expression. Biochem. J. 314 (1996) 839-845
    • (1996) Biochem. J. , vol.314 , pp. 839-845
    • Miettinen, M.M.1    Mustonen, M.J.V.2    Poutanen, M.H.3    Isomaa, V.V.4    Vihko, R.K.5
  • 42
  • 43
    • 1542722297 scopus 로고    scopus 로고
    • Identification and characterization of 17β-hydroxysteroid dehydrogenases in zebra fish, Denio rerio
    • Mindnich R., Deluca D., and Adamski J. Identification and characterization of 17β-hydroxysteroid dehydrogenases in zebra fish, Denio rerio. Mol. Cell. Endocrinol. 215 (2004) 19-30
    • (2004) Mol. Cell. Endocrinol. , vol.215 , pp. 19-30
    • Mindnich, R.1    Deluca, D.2    Adamski, J.3
  • 44
    • 0035546023 scopus 로고    scopus 로고
    • Involvement of up-regulation of 17beta-hydroxysteroid dehydrogenase type 1 in maintenance of intratumoral high estradiol levels in postmenopausal breast cancers
    • Miyoshi Y., Ando A., Shiba E., Taguchi T., Tamaki Y., and Noguchi S. Involvement of up-regulation of 17beta-hydroxysteroid dehydrogenase type 1 in maintenance of intratumoral high estradiol levels in postmenopausal breast cancers. Int. J. Cancer 94 (2001) 685-689
    • (2001) Int. J. Cancer , vol.94 , pp. 685-689
    • Miyoshi, Y.1    Ando, A.2    Shiba, E.3    Taguchi, T.4    Tamaki, Y.5    Noguchi, S.6
  • 45
    • 0028928064 scopus 로고
    • Transformation of estrone and estradiol in hormone-dependent and hormone-independent human breast cancer cells. Effects of the antiestrogen ICI 164,384, danazol, and promegestone (R-5020)
    • Nguyen B.-L., Chetrite G., and Pasqualini J.R. Transformation of estrone and estradiol in hormone-dependent and hormone-independent human breast cancer cells. Effects of the antiestrogen ICI 164,384, danazol, and promegestone (R-5020). Breast Cancer Res. Treat. 34 (1995) 139-146
    • (1995) Breast Cancer Res. Treat. , vol.34 , pp. 139-146
    • Nguyen, B.-L.1    Chetrite, G.2    Pasqualini, J.R.3
  • 46
    • 0032230308 scopus 로고    scopus 로고
    • Expression cloning of a novel estragenic mouse 17beta-hydroxysteroid dehydrogenase/17ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat
    • Nokelainen P., Peltoketo H., Vihko R., and Vihko P. Expression cloning of a novel estragenic mouse 17beta-hydroxysteroid dehydrogenase/17ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat. Mol. Endocrinol. 12 (1998) 1059-1084
    • (1998) Mol. Endocrinol. , vol.12 , pp. 1059-1084
    • Nokelainen, P.1    Peltoketo, H.2    Vihko, R.3    Vihko, P.4
  • 47
    • 2542492928 scopus 로고    scopus 로고
    • The selective estrogen enzyme modulators in breast cancer: a review
    • Pasqualini J.R. The selective estrogen enzyme modulators in breast cancer: a review. Biochim. Biophys. Acta 1654 (2004) 123-143
    • (2004) Biochim. Biophys. Acta , vol.1654 , pp. 123-143
    • Pasqualini, J.R.1
  • 49
    • 0029872530 scopus 로고    scopus 로고
    • Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer
    • Pasqualini J.R., Chetrite G., Blacker C., Feinstein M.-C., Delalonde L., Talbi M., and Maloche C. Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer. J. Clin. Endocrinol. Metab. 81 (1996) 1460-1464
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 1460-1464
    • Pasqualini, J.R.1    Chetrite, G.2    Blacker, C.3    Feinstein, M.-C.4    Delalonde, L.5    Talbi, M.6    Maloche, C.7
  • 50
    • 0032586817 scopus 로고    scopus 로고
    • 17beta-hydroxysteroid dehydrogenase (HSD)/17ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes
    • Peltoketo H., Luu-The V., Simard J., and Adamski J. 17beta-hydroxysteroid dehydrogenase (HSD)/17ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes. J. Mol. Endocrinol. 23 (1999) 1-11
    • (1999) J. Mol. Endocrinol. , vol.23 , pp. 1-11
    • Peltoketo, H.1    Luu-The, V.2    Simard, J.3    Adamski, J.4
  • 51
    • 0037277521 scopus 로고    scopus 로고
    • Inhibitors of 17beta-hydroxysteroid dehydrogenase
    • Poirier D. Inhibitors of 17beta-hydroxysteroid dehydrogenase. Curr. Med. Chem. 10 (2003) 453-477
    • (2003) Curr. Med. Chem. , vol.10 , pp. 453-477
    • Poirier, D.1
  • 52
    • 29744458970 scopus 로고    scopus 로고
    • Estradiol hybrid compounds designed to inhibit type 1 17β-hydroxysteroid dehydrogenase
    • Poirier D., Boivin R.P., Tremblay M.R., Berube M., Qiu W., and Lin S.-X. Estradiol hybrid compounds designed to inhibit type 1 17β-hydroxysteroid dehydrogenase. J. Med. Chem. 48 (2005) 8134-8147
    • (2005) J. Med. Chem. , vol.48 , pp. 8134-8147
    • Poirier, D.1    Boivin, R.P.2    Tremblay, M.R.3    Berube, M.4    Qiu, W.5    Lin, S.-X.6
  • 53
    • 33644887991 scopus 로고    scopus 로고
    • Estradiol C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase
    • Poirier D., Chang H.-K., Azzi A., Boivin R., Lin P., and Estrone S.-X. Estradiol C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase. Mol. Cell. Endocrinol. 248 (2006) 236-238
    • (2006) Mol. Cell. Endocrinol. , vol.248 , pp. 236-238
    • Poirier, D.1    Chang, H.-K.2    Azzi, A.3    Boivin, R.4    Lin, P.5    Estrone, S.-X.6
  • 54
    • 0022536513 scopus 로고
    • Stimulation of cell proliferation and estrogen response by adrenal C19-delta 5-steroids in the ZR-75-1 human breast cancer cell line
    • Poulin R., and Labrie F. Stimulation of cell proliferation and estrogen response by adrenal C19-delta 5-steroids in the ZR-75-1 human breast cancer cell line. Cancer Res. 46 (1986) 4933-4937
    • (1986) Cancer Res. , vol.46 , pp. 4933-4937
    • Poulin, R.1    Labrie, F.2
  • 55
    • 0031027687 scopus 로고    scopus 로고
    • Characterization of structural and functional properties of human 17β-Hydroxysteroid Hehydrogenase type 1 using recombinant enzymes and site-directed mutagenis
    • Puranen T., Poutanen M., Ghosh D., Vihko P., and Vihko R. Characterization of structural and functional properties of human 17β-Hydroxysteroid Hehydrogenase type 1 using recombinant enzymes and site-directed mutagenis. Mol. Endocrinol. 11 (1997) 77-86
    • (1997) Mol. Endocrinol. , vol.11 , pp. 77-86
    • Puranen, T.1    Poutanen, M.2    Ghosh, D.3    Vihko, P.4    Vihko, R.5
  • 56
    • 0036831679 scopus 로고    scopus 로고
    • A concerted, rational design of 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrid with high affinity
    • Qiu W., Campbell R.L., Gangloff A., Dupuis P., Boivin P., Tremblay M.R., Poirier D., and Lin S.-X. A concerted, rational design of 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrid with high affinity. FASEB J. 16 (2002) 1829-1931
    • (2002) FASEB J. , vol.16 , pp. 1829-1931
    • Qiu, W.1    Campbell, R.L.2    Gangloff, A.3    Dupuis, P.4    Boivin, P.5    Tremblay, M.R.6    Poirier, D.7    Lin, S.-X.8
  • 58
    • 33747588055 scopus 로고    scopus 로고
    • The role of aromatase and 17-β-hydroxysteroid dehydrogenase type 1 mRNA expression in predicting the clinical outcome of human breast cancer
    • Salhab M., Reed M.J., Al Sarakbi W., Jiang W.G., and Mokbel K. The role of aromatase and 17-β-hydroxysteroid dehydrogenase type 1 mRNA expression in predicting the clinical outcome of human breast cancer. Breast Cancer Res. Treat. 99 (2006) 155-162
    • (2006) Breast Cancer Res. Treat. , vol.99 , pp. 155-162
    • Salhab, M.1    Reed, M.J.2    Al Sarakbi, W.3    Jiang, W.G.4    Mokbel, K.5
  • 59
    • 0021149871 scopus 로고
    • In situ estrogen production via estrone sulfatase pathway in breast tumors: relative importance versus the aromatase pathway
    • Santner S.J., Feil P.D., and Santen R.J. In situ estrogen production via estrone sulfatase pathway in breast tumors: relative importance versus the aromatase pathway. J. Clin. Endocrinol. Metab. 59 (1984) 29-33
    • (1984) J. Clin. Endocrinol. Metab. , vol.59 , pp. 29-33
    • Santner, S.J.1    Feil, P.D.2    Santen, R.J.3
  • 60
    • 33746788624 scopus 로고    scopus 로고
    • New development in intracrinology of breast carcinoma
    • Sasano H., Suzushi T., Nakata N., and Mariya T. New development in intracrinology of breast carcinoma. Breast Cancer 13 (2006) 129-136
    • (2006) Breast Cancer , vol.13 , pp. 129-136
    • Sasano, H.1    Suzushi, T.2    Nakata, N.3    Mariya, T.4
  • 61
    • 47749148101 scopus 로고    scopus 로고
    • Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries
    • Schuster D., Nashev L.G., Kirchmair J., Laggner C., Wobler G., Langer T., and Odermatt A. Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. J. Med. Chem. 51 (2008) 4188-4199
    • (2008) J. Med. Chem. , vol.51 , pp. 4188-4199
    • Schuster, D.1    Nashev, L.G.2    Kirchmair, J.3    Laggner, C.4    Wobler, G.5    Langer, T.6    Odermatt, A.7
  • 62
    • 52149090793 scopus 로고    scopus 로고
    • Bioluminescent animal models of human breast cancer for tumor biomass evaluation and metastasis detection
    • S2-65-S2-69
    • Shan L., Wang S., Korotcov A., Sridhar R., and Wang P.C. Bioluminescent animal models of human breast cancer for tumor biomass evaluation and metastasis detection. Ethn. Dis. Spring. 18 2 Suppl. 2 (2008) S2-65-S2-69
    • (2008) Ethn. Dis. Spring. , vol.18 , Issue.2 SUPPL. 2
    • Shan, L.1    Wang, S.2    Korotcov, A.3    Sridhar, R.4    Wang, P.C.5
  • 63
    • 1942437384 scopus 로고    scopus 로고
    • Cofactor hydrogen bonding onto the protein main chain is conserved in the short-chain dehydrogenase/reductase family and contributes to nicotinamide orientation
    • Shi R., and Lin S.-X. Cofactor hydrogen bonding onto the protein main chain is conserved in the short-chain dehydrogenase/reductase family and contributes to nicotinamide orientation. J. Biol. Chem. 279 (2004) 16778-16785
    • (2004) J. Biol. Chem. , vol.279 , pp. 16778-16785
    • Shi, R.1    Lin, S.-X.2
  • 66
    • 0021319221 scopus 로고
    • Do hormones cause breast cancer?
    • Thomas D.B. Do hormones cause breast cancer?. Cancer 53 (1984) 595-604
    • (1984) Cancer , vol.53 , pp. 595-604
    • Thomas, D.B.1
  • 67
    • 0022905710 scopus 로고
    • Steroid dynamics in the normal and carcinomatous mammary gland
    • Vermeulen A., Deslypere J.P., and Paridaens R. Steroid dynamics in the normal and carcinomatous mammary gland. J. Steroid Biochem. 25 (1986) 799-802
    • (1986) J. Steroid Biochem. , vol.25 , pp. 799-802
    • Vermeulen, A.1    Deslypere, J.P.2    Paridaens, R.3
  • 68
    • 0024517636 scopus 로고
    • Endogenous steroids in the pathophysiology of breast cancer
    • Vihko R., and Apter D. Endogenous steroids in the pathophysiology of breast cancer. Crit. Rev. Oncol. Hematol. 9 (1989) 1-16
    • (1989) Crit. Rev. Oncol. Hematol. , vol.9 , pp. 1-16
    • Vihko, R.1    Apter, D.2
  • 70
    • 0032031754 scopus 로고    scopus 로고
    • In situ aromatization enhances breast tumor estradiol levels and cellular proliferation
    • Yue W., Wang J.-P., Hamilton C.J., Demers L.M., and Santen R.J. In situ aromatization enhances breast tumor estradiol levels and cellular proliferation. Cancer Res. 58 (1998) 927-932
    • (1998) Cancer Res. , vol.58 , pp. 927-932
    • Yue, W.1    Wang, J.-P.2    Hamilton, C.J.3    Demers, L.M.4    Santen, R.J.5


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