Estradiol and estrone C-16 derivatives as inhibitors of type 1 17β-hydroxysteroid dehydrogenase: Blocking of ER+ breast cancer cell proliferation induced by estrone

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 4, 2008, Pages 1849-1860

  Laplante, Yannick ^a   Cadot, Christine ^a   Fournier, Michelle Audrey ^a   Poirier, Donald ^a  

^a UNIVERSITÉ LAVAL   (Canada)

Author keywords

17 hydroxysteroid dehydrogenase; Cancer; Enzyme; Estrogen; Inhibitor; MCF 7 cells; Medicinal chemistry; Steroid; T 47D cells

Indexed keywords

16 BETA M CARBAMOYLBENZYL ESTRADIOL; 3 (17BETA HYDROXY 3 METHOXY ESTRA 1,3,5(10) TRIEN 16BETA YLMETHYL)BENZAMIDE; 3 (17BETA HYDROXY ESTRA 1,3,5(10) TRIEN 16BETA YLMETHYL)BENZAMIDE; 3 (3 HYDROXY 17 OXO ESTRA 1,3,5(10) TRIEN 16BETA YLMETHYL)BENZAMIDE; 3 (3 METHOXY 17 OXO ESTRA 1,3,5(10) TRIEN 16BETA YLMETHYL)BENZAMIDE; 3 (3,17BETA DIHYDROXY 2 METHOXY ESTRA 1,3,5(10) TRIEN 16BETA YLMETHYL)BENZAMIDE; 3 (3,17BETA DIHYDROXY ESTRA 1,3,5(10) TRIEN 16BETA YLMETHYL)BENZAMIDE; 4 (17BETA HYDROXY 3 METHOXY ESTRA 1,3,5(10) TRIEN 16BETA YLMETHYL)BENZAMIDE; 4 (3 HYDROXY 17 OXO ESTRA 1,3,5(10) TRIEN 16BETA YLMETHYL)BENZAMIDE; 4 (3 METHOXY 17 OXO ESTRA 1,3,5(10) TRIEN 16BETA YLMETHYL)BENZAMIDE; 4 (3,17BETA DIHYDROXY ESTRA 1,3,5(10) TRIEN 16BETA YLMETHYL)BENZAMIDE; AMIDE; BENZYL DERIVATIVE; ESTRADIOL; ESTRONE; HYDROGEN; HYDROXYL GROUP; N BUTYL N METHYL 11 [16BETA (3 CARBAMOYLBENZYL) 3,17 DIHYDROXY ESTRA 1,3,5(10) TRIEN 7A YL]UNDECANAMIDE; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CELL PROLIFERATION; ENZYME ACTIVITY; ESTROGEN ACTIVITY; HUMAN; HUMAN CELL; IC 50; INCUBATION TIME; STRUCTURE ACTIVITY RELATION;

17-HYDROXYSTEROID DEHYDROGENASES; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME INHIBITORS; ESTRADIOL; ESTRONE; FEMALE; HUMANS; RECEPTORS, ESTROGEN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 38949103729     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.007     Document Type: Article

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