Critical residues for the specificity of cofactors and substrates in human estrogenic 17β-hydroxysteroid dehydrogenase 1: Variants designed from the three-dimensional structure of the enzyme

Molecular Endocrinology

Volumn 15, Issue 11, 2001, Pages 2010-2020

  Huang, Y W ^a   Pineau, I ^a   Chang, H J ^a   Azzi, A ^a   Bellemare, V ^a   Laberge, S ^a   Lin, S X ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ESTRADIOL 17BETA DEHYDROGENASE; GLUTAMINE; HISTIDINE; LYSINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SERINE PROTEINASE;

ARTICLE; BINDING SITE; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS;

17-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CELLS, CULTURED; HISTIDINE; HUMANS; LEUCINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; NAD; NADP; PROTEIN CONFORMATION; SERINE;

EID: 0034749467     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.15.11.2010     Document Type: Article

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