Novel derivatives of 6-mercaptopurine: Synthesis, characterization and antiproliferative activities of S-allylthio-mercaptopurines

European Journal of Medicinal Chemistry

Volumn 44, Issue 2, 2009, Pages 541-550

  Miron, T ^a   Arditti, F ^a   Konstantinovski, L ^a   Rabinkov, A ^a   Mirelman, D ^a   Berrebi, A ^b   Wilchek, M ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b KAPLAN MEDICAL CENTER   (Israel)

Author keywords

6 Mercaptopurine; Allicin; Antiproliferative effect; Apoptosis; Human tumor cell lines; Prodrug; S Allylthio 6 mercaptopurine

Indexed keywords

6 MERCAPTOPURINE DERIVATIVE; ALLYLTHIO 6 MERCAPTOPURINE; ALLYLTHIO 6 MERCAPTOPURINE RIBOSIDE; ALLYLTHIOGLUTATHIONE; ALLYLTHIOMERCAPTOPURINE DERIVATIVE; GLUTATHIONE; MERCAPTOPURINE RIBOSIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL ASSAY; CELL PROLIFERATION; CELL VIABILITY; CHEMICAL REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG PENETRATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC 50; LEUKEMIA CELL; MITOSIS INHIBITION; MONOLAYER CULTURE;

6-MERCAPTOPURINE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 60149105198     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.03.027     Document Type: Article

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