The metabolism of CYP2C9 and CYP2C19 for gliclazide by homology modeling and docking study

European Journal of Medicinal Chemistry

Volumn 44, Issue 2, 2009, Pages 854-861

  Yao, Yuan ^a   Han, Wei Wei ^a   Zhou, Yi Han ^a   Li, Ze Sheng ^a   Li, Qiang ^b   Chen, Xiao Yan ^b   Zhong, Da Fang ^b  

^a JILIN UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cytochrome P450 protein; Gliclazide; Molecular docking; Substrate inhibition

Indexed keywords

6BETA HYDROXYGLICLAZIDE; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; DRUG METABOLITE; GLICLAZIDE; METHYLHYDROXYGLICLAZIDE; UNCLASSIFIED DRUG;

ARTICLE; AUTOMATION; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG METABOLISM; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HYDROXYLATION; MICHAELIS MENTEN KINETICS; MOLECULAR DOCKING; MOLECULAR DYNAMICS; RELIABILITY; SEQUENCE HOMOLOGY; SIMULATION; THREE DIMENSIONAL IMAGING;

ARYL HYDROCARBON HYDROXYLASES; CATALYTIC DOMAIN; COMPUTER SIMULATION; GLICLAZIDE; HUMANS; HYDROXYLATION; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 60149091229     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.04.015     Document Type: Article

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