Simultaneous determination of metformin and gliclazide in human plasma by liquid chromatography-tandem mass spectrometry: Application to a bioequivalence study of two formulations in healthy volunteers

Journal of Mass Spectrometry

Volumn 40, Issue 11, 2005, Pages 1462-1471

  Zhong, Guo Ping ^a   Bi, Hui Chang ^a   Zhou, Shufeng ^b   Chen, Xiao ^a   Huang, Min ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Bioavailability; Bioequivalence; Gliclazide; Liquid chromatography tandem mass spectrometry; Metformin; Pharmacokinetics

Indexed keywords

ACETONITRILE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; QUALITY CONTROL;

BIOAVAILABILITY; BIOEQUIVALENCE; GLICLAZIDE; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; METFORMIN;

BODY FLUIDS;

ACETONITRILE; GLICLAZIDE; HUPERZINE A; METFORMIN;

ACCURACY; ADULT; ARTICLE; BIOEQUIVALENCE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG FORMULARY; ELECTROSPRAY; HUMAN; INSTRUMENTATION; INTERMETHOD COMPARISON; LINEAR SYSTEM; LIQUID CHROMATOGRAPHY; MALE; NORMAL HUMAN; PRECIPITATION; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; REACTION TIME; SENSITIVITY ANALYSIS; STANDARD; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

CALIBRATION; CHROMATOGRAPHY, LIQUID; GLICLAZIDE; HEALTH; HUMANS; METFORMIN; MOLECULAR STRUCTURE; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THERAPEUTIC EQUIVALENCY;

EID: 27944487004     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/jms.907     Document Type: Article

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