Rapid and sensitive method for the determination of sibutramine active metabolites in human plasma by reversed-phase liquid chromatography-tandem mass spectroscopy

Journal of Chromatographic Science

Volumn 45, Issue 2, 2007, Pages 91-96

  Bhatt, Jignesh ^a,b   Shah, Bhavin ^a   Kambli, Sandeep ^a   Subbaiah, Gunta ^a   Singh, Sadhana ^b   Ameta, Suresh ^b  

^a Torrent Research Centre   (India)

^b M L SUKHADIA UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33846817131     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/45.2.91     Document Type: Article

References (5)

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2. S.C. Cheetham, J.A. Viggers, N.A. Slater, and W.R. Buckett. Inhibition of [3H] paroxetine binding by sibutramine, its metabolites and other antidepressants. Br. J. Pharmacol 101: 515 (1990).
3. I.D. Hind, J.E. Mangham, S.P. Ghani, R.E. Haddock, C.J. Garratt, and R.W. Jones. Sibutramine pharmacokinetics in young and elderly healthy subjects. E. J. Clin. Pharmacol. 54: 847-49 (1999).
4. J.Y. Park, K.A. Kim, P.W. Park, K.H. Sah, and G.S. Lee. Relative bioavailability and pharmacokinetics of a new sibutramine formulation in healthy male subjects: a randomized, open-label, two-period, comparative crossover study. Clin Ther 26: 2092-2101 (2004).
5. J. Chen, W. Lu, Q. Zhang, and X. Jiang. Determination of the active metabolite of sibutramine by liquid chromatography-electrospray ionization tandem mass spectrometry. J. Chromatogr. B. Analyst. Technol. Biomed. Life Sci. 5: 197-203 (2003).