The peripheral pro-nociceptive state induced by repetitive inflammatory stimuli involves continuous activation of protein kinase A and protein kinase C epsilon and its NaV1.8 sodium channel functional regulation in the primary sensory neuron

Biochemical Pharmacology

Volumn 77, Issue 5, 2009, Pages 867-877

  Villarreal, Cristiane Flora ^a   Sachs, Daniela ^b   Funez, Mani Indiana ^b   Parada, Carlos Amílcar ^c   de Queiroz Cunha, Fernando ^b   Ferreira, Sérgio Henrique ^b  

^a FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Chronic pain; Inflammatory pain; NaV1.8 sodium channel; PKA; PKC ; Primary sensory neuron

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; DIPYRONE; MESSENGER RNA; PROSTAGLANDIN E2; PROTEIN KINASE C EPSILON; PROTEIN KINASE C INHIBITOR; SODIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CHRONIC PAIN; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; EXPERIMENTAL MODEL; GENE CONTROL; HYPERNOCICEPTION; INFLAMMATION; MALE; MOLECULAR INTERACTION; NOCICEPTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SENSITIZATION; SENSORY NERVE CELL; SPINAL GANGLION; UPREGULATION;

ANIMALS; BASE SEQUENCE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DINOPROSTONE; DNA PRIMERS; ENZYME ACTIVATION; INFLAMMATION; MALE; NERVE TISSUE PROTEINS; PAIN; POLYMERASE CHAIN REACTION; PROTEIN KINASE C-EPSILON; RATS; RATS, WISTAR; SODIUM CHANNELS;

EID: 59749090393     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.11.015     Document Type: Article

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