Sodium channel Nav1.8 immunoreactivity in painful human dental pulp

BMC Oral Health

Volumn 5, Issue , 2005, Pages

  Renton, T ^a   Yiangou, Y ^b   Plumpton, C ^c   Tate, S ^c   Bountra, C ^c   Anand, P ^b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; SODIUM; SODIUM CHANNEL;

ADULT; ANTIBODY SPECIFICITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FIBER; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; ISOLATED ORGAN; MALE; NEUROFILAMENT; PAIN; TOOTH EXTRACTION; TOOTH PULP DISEASE;

EID: 23944501347     PISSN: 14726831     EISSN: 14726831     Source Type: Journal    
DOI: 10.1186/1472-6831-5-5     Document Type: Article

References (18)

1. Reader A, Foreman DW: An ultrastructural quantitative investigation of human intradental innervation. J Endod 1981, 7:493-499.
2. Hildebrand C, Fried K, Tuisku F, Johansson CS: Teeth and tooth nerves. Prog Neurobiol 1995, 45:165-222.
3. Fried K, Hildebrand C: Pulpal axons in developing, mature, and aging feline permanent incisors. A study by electron microscopy. J Comp Neurol 1981, 203:23-36.
4. Narhi M: The neurophysiology of the teeth. Dent Clin North Am 1990, 34:439-448.
5. Tyldesley WR, Mumford JM: Dental pain and the histological condition of the pulp. Dent Pract Dent Rec 1970, 20:333-336.
6. Seltzer S: Hypothetic mechanisms for dentine sensitivity. Oral Surg Oral Med Oral Pathol 1971, 31:388-399.
7. Waxman SG: The molecular pathophysiology of pain: abnormal expression of sodium channel genes and its contributions to hyperexcitability of primary sensory neurons. Pain 1999, Suppl 6:S133-40.
8. Lai J, Gold MS, Kim CS, Bian D, Ossipov MH, Hunter JC, Porreca F: Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8. Pain 2002, 95:143-152.
9. Coward K, Plumpton C, Facer P, Birch R, Carlstedt T, Tate S, Bountra C, Anand P: Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states. Pain 2000, 85:41-50.
10. Akopian AN, Sivilotti L, Wood JN: A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature 1996, 379:257-262.
11. Maeda T, Iwanaga T, Fujita T, Kobayashi S: Immunohistochemical demonstration of nerves in the predentin and dentin of human third molars with the use of an antiserum against neurofilament protein (NFP). Cell Tissue Res 1986, 243:469-475.
12. Alavi AM, Dubyak GR, Burnstock G: Immunohistochemical evidence for ATP receptors in human dental pulp. J Dent Res 2001, 80:476-483.
13. Taylor PE, Byers MR, Redd PE: Sprouting of CGRP nerve fibers in response to dentin injury in rat molars. Brain Res 1988, 461:371-376.
14. Rodd HD, Boissonade FM: Substance P expression in human tooth pulp in relation to caries and pain experience. Eur J Oral Sci 2000, 108:467-474.
15. Awawdeh L, Lundy FT, Shaw C, Lamey PJ, Linden GJ, Kennedy JG: Quantitative analysis of substance P, neurokinin A and calcitonin gene-related peptide in pulp tissue from painful and healthy human teeth. Int Endod J 2002, 35:30-36.
16. Renton T, Yiangou Y, Baecker PA, Ford AP, Anand P: Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp. J Orofac Pain 2003, 17:245-250.
17. Doubleday B, Robinson PP: Nerve growth factor depletion reduces collateral sprouting of cutaneous mechanoreceptive and tooth-pulp axons in ferrets. J Physiol 1994, 481 ( Pt 3):709-718.
18. Henry MA, Sorensen HJ, Johnson LR, Levinson SR: Localization of the Na(v)1.8 sodium channel isoform at nodes of Ranvier in normal human radicular tooth pulp. Neurosci Lett 2005, 380:32-36.