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Volumn 150, Issue 2, 2009, Pages 862-870

A selective peroxisome proliferator-activated receptor-γ modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN; TELMISARTAN; TROGLITAZONE;

EID: 59649118827     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-0502     Document Type: Article
Times cited : (27)

References (63)
  • 1
    • 0031445202 scopus 로고    scopus 로고
    • Comparison of type 1 angiotensin II receptor blockers and angiotensin converting enzyme inhibitors in the treatment of hypertension
    • Weber MA 1997 Comparison of type 1 angiotensin II receptor blockers and angiotensin converting enzyme inhibitors in the treatment of hypertension. J Hypertens 15(Suppl):S31-S36
    • (1997) J Hypertens , vol.15 , Issue.SUPPL.
    • Weber, M.A.1
  • 2
    • 0037160968 scopus 로고    scopus 로고
    • Dahl of B, Devereux RB, Kjeldsen SE, Julius S, Beevers G, de Faire U, Fyhrquist F, Ibsen H, Kristiansson K, Lederballe-Pedersen O, Lindholm LH, Nieminen MS, Omvik P, Oparil S, Wedel H; LIFE Study Group 2002 Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 359:995-1003
    • Dahl of B, Devereux RB, Kjeldsen SE, Julius S, Beevers G, de Faire U, Fyhrquist F, Ibsen H, Kristiansson K, Lederballe-Pedersen O, Lindholm LH, Nieminen MS, Omvik P, Oparil S, Wedel H; LIFE Study Group 2002 Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 359:995-1003
  • 3
    • 0042410539 scopus 로고    scopus 로고
    • Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJ, Michelson EL, Olofsson B, Ostergren J, Yusuf S, Pocock S; CHARM Investigators and Committees 2003 Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet 362:759-766
    • Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJ, Michelson EL, Olofsson B, Ostergren J, Yusuf S, Pocock S; CHARM Investigators and Committees 2003 Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet 362:759-766
  • 4
    • 2942635317 scopus 로고    scopus 로고
    • Julius S, Kjeldsen SE, Weber M, Brunner HR, Ekman S, Hansson L, Hua T, Laragh J, McInnes GT, Mitchell L, Plat F, Schork A, Smith B, Zanchetti A; VALUE trial group 2004 Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet 363:2022-2031
    • Julius S, Kjeldsen SE, Weber M, Brunner HR, Ekman S, Hansson L, Hua T, Laragh J, McInnes GT, Mitchell L, Plat F, Schork A, Smith B, Zanchetti A; VALUE trial group 2004 Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet 363:2022-2031
  • 5
    • 0035724736 scopus 로고    scopus 로고
    • Selective angiotensin II receptor antagonism reduces insulin resistance in obese Zucker rats
    • Henriksen EJ, Jacob S, Kinnick TR, Teachey MK, Krekler M 2001 Selective angiotensin II receptor antagonism reduces insulin resistance in obese Zucker rats. Hypertension 38:884-890
    • (2001) Hypertension , vol.38 , pp. 884-890
    • Henriksen, E.J.1    Jacob, S.2    Kinnick, T.R.3    Teachey, M.K.4    Krekler, M.5
  • 7
    • 0034874986 scopus 로고    scopus 로고
    • Telmisartan: A review of its use in hypertension
    • Sharpe M, Jarvis B, Goa KL 2001 Telmisartan: a review of its use in hypertension. Drugs 61:1501-1529
    • (2001) Drugs , vol.61 , pp. 1501-1529
    • Sharpe, M.1    Jarvis, B.2    Goa, K.L.3
  • 8
    • 2442451618 scopus 로고    scopus 로고
    • Angiotensin type 1 receptor blockers induce peroxisome proliferators-activated receptor-γ activity
    • Schupp M, Janke J, Clasen R, Unger T, Kintscher U 2004 Angiotensin type 1 receptor blockers induce peroxisome proliferators-activated receptor-γ activity. Circulation 109:2054-2057
    • (2004) Circulation , vol.109 , pp. 2054-2057
    • Schupp, M.1    Janke, J.2    Clasen, R.3    Unger, T.4    Kintscher, U.5
  • 10
    • 0025812291 scopus 로고
    • Directrepeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D receptors
    • Umesono K, MurakamiKK, ThompsonCC, Evans RM1991 Directrepeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D receptors. Cell 65:1255-1266
    • (1991) Cell , vol.65 , pp. 1255-1266
    • Umesono, K.1    Murakami, K.K.2    Thompson, C.C.3    Evans, R.M.4
  • 13
    • 0028846193 scopus 로고
    • Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
    • Onate SA, Tsai SY, Tsai MJ, O'Malley BW 1995 Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270:1354-1357
    • (1995) Science , vol.270 , pp. 1354-1357
    • Onate, S.A.1    Tsai, S.Y.2    Tsai, M.J.3    O'Malley, B.W.4
  • 14
    • 0030771856 scopus 로고    scopus 로고
    • Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor
    • Zhu Y, Qi C, Jain S, Rao MS, Reddy JK 1997 Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J Biol Chem 272:25500-25506
    • (1997) J Biol Chem , vol.272 , pp. 25500-25506
    • Zhu, Y.1    Qi, C.2    Jain, S.3    Rao, M.S.4    Reddy, J.K.5
  • 15
    • 0032493455 scopus 로고    scopus 로고
    • The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
    • Yuan CX, Ito M, Fondell JD, Fu ZY, Roeder RG 1998 The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc Natl Acad Sci USA 95:7939-7944
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7939-7944
    • Yuan, C.X.1    Ito, M.2    Fondell, J.D.3    Fu, Z.Y.4    Roeder, R.G.5
  • 16
    • 0032525781 scopus 로고    scopus 로고
    • A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system
    • Rachez C, Suldan Z, Ward J, Chang C-P, Burakov D, Erdjument-Bromage H, Tempst P, Freedman LP 1998 A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. Genes Dev 12:1787-1800
    • (1998) Genes Dev , vol.12 , pp. 1787-1800
    • Rachez, C.1    Suldan, Z.2    Ward, J.3    Chang, C.-P.4    Burakov, D.5    Erdjument-Bromage, H.6    Tempst, P.7    Freedman, L.P.8
  • 17
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver P, Wu Z, Park CW, Graves R, Wright M, SpiegelmanBM1998 A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    SpiegelmanBM6
  • 18
    • 0033513582 scopus 로고    scopus 로고
    • Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: Discovery of peptide antagonists of estrogen receptors α and β
    • Chang CY, Norris JD, Grøn H, Paige LA, Hamilton PT, Kenan DJ, Fowlkes D, Mcdonnell DP 1999 Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors α and β. Mol Cell Biol 19:8226-8239
    • (1999) Mol Cell Biol , vol.19 , pp. 8226-8239
    • Chang, C.Y.1    Norris, J.D.2    Grøn, H.3    Paige, L.A.4    Hamilton, P.T.5    Kenan, D.J.6    Fowlkes, D.7    Mcdonnell, D.P.8
  • 19
    • 0030480969 scopus 로고    scopus 로고
    • The CBP co-activator is a histone acetyltransferase
    • Bannister A, Kouzarides 1996 The CBP co-activator is a histone acetyltransferase. Nature 384:641-643
    • (1996) Nature , vol.384 , pp. 641-643
    • Bannister, A.1    Kouzarides2
  • 20
    • 0030740253 scopus 로고    scopus 로고
    • Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimetric activation complex with P/CAF and CBP/p300
    • Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM 1997 Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimetric activation complex with P/CAF and CBP/p300. Cell 90:569-580
    • (1997) Cell , vol.90 , pp. 569-580
    • Chen, H.1    Lin, R.J.2    Schiltz, R.L.3    Chakravarti, D.4    Nash, A.5    Nagy, L.6    Privalsky, M.L.7    Nakatani, Y.8    Evans, R.M.9
  • 23
    • 0024869336 scopus 로고
    • Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor
    • Brent GA, Dunn MK, Harney JW, Gulick T, Larsen PR, Moore DD 1989 Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor. New Biol 1:329-336
    • (1989) New Biol , vol.1 , pp. 329-336
    • Brent, G.A.1    Dunn, M.K.2    Harney, J.W.3    Gulick, T.4    Larsen, P.R.5    Moore, D.D.6
  • 24
    • 0024336324 scopus 로고
    • Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist
    • Damm K, Thompson CC, Evans RM 1989 Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist. Nature 339:593-597
    • (1989) Nature , vol.339 , pp. 593-597
    • Damm, K.1    Thompson, C.C.2    Evans, R.M.3
  • 25
    • 0037022592 scopus 로고    scopus 로고
    • The peroxisome proliferators-activated receptor δ, an integrator of transcriptional repression and nuclear signaling
    • Shi Y, Hon M, Evans RM 2002 The peroxisome proliferators-activated receptor δ, an integrator of transcriptional repression and nuclear signaling. Proc Natl Acad Sci USA 99:2613-2618
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 2613-2618
    • Shi, Y.1    Hon, M.2    Evans, R.M.3
  • 29
    • 0028890361 scopus 로고
    • Interaction of thyroid-hormone receptor with a conserved transcriptional mediator
    • Lee JW, Ryan F, Swaffield JC, Johnston SA, Moore DD 1995 Interaction of thyroid-hormone receptor with a conserved transcriptional mediator. Nature 374:91-94
    • (1995) Nature , vol.374 , pp. 91-94
    • Lee, J.W.1    Ryan, F.2    Swaffield, J.C.3    Johnston, S.A.4    Moore, D.D.5
  • 30
    • 0029097233 scopus 로고
    • A transcriptional co-repressor that interacts with nuclear hormone receptors
    • Chen JD, Evans RM 1995 A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377:454-457
    • (1995) Nature , vol.377 , pp. 454-457
    • Chen, J.D.1    Evans, R.M.2
  • 31
    • 0029657787 scopus 로고    scopus 로고
    • IdentificationofTRACs(T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors
    • SandeS, PrivalskyML1996 IdentificationofTRACs(T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors. Mol Endocrinol 10:813-825
    • (1996) Mol Endocrinol , vol.10 , pp. 813-825
    • SandeS1    PrivalskyML2
  • 36
    • 0032553542 scopus 로고    scopus 로고
    • Uppenberg J, Svensson C, Jaki M, Bertilsson G, Jendeberg L, Berkenstam A 1998Crystal structure of the ligand binding domain of the human nuclear receptor PPARy. J Biol Chem 273:31108-3111222
    • Uppenberg J, Svensson C, Jaki M, Bertilsson G, Jendeberg L, Berkenstam A 1998Crystal structure of the ligand binding domain of the human nuclear receptor PPARy. J Biol Chem 273:31108-3111222
  • 37
    • 0030974043 scopus 로고    scopus 로고
    • Nuclear receptor core- pressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone
    • Tagami T, Madison LD, Nagaya T, Jameson JL 1997 Nuclear receptor core- pressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone. Mol Cell Biol 17:2642-2648
    • (1997) Mol Cell Biol , vol.17 , pp. 2642-2648
    • Tagami, T.1    Madison, L.D.2    Nagaya, T.3    Jameson, J.L.4
  • 38
    • 0033529543 scopus 로고    scopus 로고
    • Mechanisms that mediate negative regulation of the thyroid-stimulating hormone alpha gene by the thyroid hormone receptor
    • Tagami T, Park Y, Jameson JL 1999 Mechanisms that mediate negative regulation of the thyroid-stimulating hormone alpha gene by the thyroid hormone receptor. J Biol Chem 274:22345-22353
    • (1999) J Biol Chem , vol.274 , pp. 22345-22353
    • Tagami, T.1    Park, Y.2    Jameson, J.L.3
  • 39
    • 0031793336 scopus 로고    scopus 로고
    • The thyroid hormone receptor variant a2 is a weak antagonist because it is deficient in interactions with nuclear receptor corepressor
    • Tagami T, Kopp P, Johnson W, Arseven OK, Jameson JL 1998 The thyroid hormone receptor variant a2 is a weak antagonist because it is deficient in interactions with nuclear receptor corepressor. Endocrinology 139:2535-2544
    • (1998) Endocrinology , vol.139 , pp. 2535-2544
    • Tagami, T.1    Kopp, P.2    Johnson, W.3    Arseven, O.K.4    Jameson, J.L.5
  • 40
    • 0032545486 scopus 로고    scopus 로고
    • The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators. Bio- chem
    • Tagami T, Lutz WH, Kumar R, Jameson JL 1998 The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators. Bio- chem Biophys Res Commun 253:358-363
    • (1998) Biophys Res Commun , vol.253 , pp. 358-363
    • Tagami, T.1    Lutz, W.H.2    Kumar, R.3    Jameson, J.L.4
  • 41
    • 0031726811 scopus 로고    scopus 로고
    • A novel natural mutation in the thyroid hormone receptor defines a dual functional domain that exchanges nuclear receptor corepressors and coactivators
    • Tagami T, Gu W, Peairs PT, West BL, Jameson JL 1998 A novel natural mutation in the thyroid hormone receptor defines a dual functional domain that exchanges nuclear receptor corepressors and coactivators. Mol Endocrinol 12:1888-1902
    • (1998) Mol Endocrinol , vol.12 , pp. 1888-1902
    • Tagami, T.1    Gu, W.2    Peairs, P.T.3    West, B.L.4    Jameson, J.L.5
  • 42
    • 15144351976 scopus 로고    scopus 로고
    • Nuclear corepressors enhance the dominantneg- ative activity of mutant receptors that cause resistance to thyroid hormone
    • Tagami T, JamesonJL 1998 Nuclear corepressors enhance the dominantneg- ative activity of mutant receptors that cause resistance to thyroid hormone. Endocrinology 139:640-650
    • (1998) Endocrinology , vol.139 , pp. 640-650
    • Tagami, T.1    JamesonJL2
  • 43
    • 0027397846 scopus 로고
    • Estimation of the protein content of thyroid hormone receptor α1 and β1 in rat tissues by Western blotting
    • Tagami T, Nakamura H, Sasaki S, Miyoshi Y, Imura H 1993 Estimation of the protein content of thyroid hormone receptor α1 and β1 in rat tissues by Western blotting. Endocrinology 132:275-279
    • (1993) Endocrinology , vol.132 , pp. 275-279
    • Tagami, T.1    Nakamura, H.2    Sasaki, S.3    Miyoshi, Y.4    Imura, H.5
  • 44
    • 3142781955 scopus 로고    scopus 로고
    • Prevention of type 2 diabetes mellitus through inhibition of the renin-angiotensin system
    • Scheen AJ 2004 Prevention of type 2 diabetes mellitus through inhibition of the renin-angiotensin system. Drugs 64:2537-2565
    • (2004) Drugs , vol.64 , pp. 2537-2565
    • Scheen, A.J.1
  • 47
    • 0034231647 scopus 로고    scopus 로고
    • Rosiglitazone: An agent from the thoazolidinedi- one class for the treatment of type 2 diabetes
    • Cheng-LaiA, Levine A 2000 Rosiglitazone: an agent from the thoazolidinedi- one class for the treatment of type 2 diabetes. Heart Dis 2:326-333
    • (2000) Heart Dis , vol.2 , pp. 326-333
    • LaiA, C.1    Levine, A.2
  • 49
    • 0029012163 scopus 로고
    • Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
    • Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras D 1995 Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α. Nature 375:377-382
    • (1995) Nature , vol.375 , pp. 377-382
    • Bourguet, W.1    Ruff, M.2    Chambon, P.3    Gronemeyer, H.4    Moras, D.5
  • 50
    • 0029643780 scopus 로고
    • Crystal structure of the RAR-γ ligand-binding domain bound to all- trans retinoic acid
    • Renaud JP, Rochel N, Ruff M, Vivat V, Chambon P, Gronemeyer H, Moras D 1995 Crystal structure of the RAR-γ ligand-binding domain bound to all- trans retinoic acid. Nature 378:681-689
    • (1995) Nature , vol.378 , pp. 681-689
    • Renaud, J.P.1    Rochel, N.2    Ruff, M.3    Vivat, V.4    Chambon, P.5    Gronemeyer, H.6    Moras, D.7
  • 53
    • 0032446607 scopus 로고    scopus 로고
    • The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
    • Shiau AK, Barstad D, Loria PM, Cheng L, Kushner PJ, Agard DA, Greene GL 1998 The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell 95:927-937
    • (1998) Cell , vol.95 , pp. 927-937
    • Shiau, A.K.1    Barstad, D.2    Loria, P.M.3    Cheng, L.4    Kushner, P.J.5    Agard, D.A.6    Greene, G.L.7
  • 55
    • 0029030016 scopus 로고
    • The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18
    • LeDouarin B, Zechel C, Garnier JM, Lutz Y, Tora L, Pierrat P, Heery D, Gronemeyer H, Chambon P, Losson R 1995 The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J 14: 2020-2033
    • (1995) EMBO J , vol.14 , pp. 2020-2033
    • LeDouarin, B.1    Zechel, C.2    Garnier, J.M.3    Lutz, Y.4    Tora, L.5    Pierrat, P.6    Heery, D.7    Gronemeyer, H.8    Chambon, P.9    Losson, R.10
  • 56
    • 0030986236 scopus 로고    scopus 로고
    • A signature motif in transcriptional co-activators mediates binding to nuclear receptors
    • Heery DM, Kalkhoven E, Hoare S, Parker MG 1997 A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387:733-736
    • (1997) Nature , vol.387 , pp. 733-736
    • Heery, D.M.1    Kalkhoven, E.2    Hoare, S.3    Parker, M.G.4
  • 58
    • 17544398986 scopus 로고    scopus 로고
    • Nagy L, Kao H-Y, Love JD, LiC, BanayoE,Gooch JT, Chatterjee VKK, Evans RM, Schwabe JWR 1999 Mechanism of corepressor binding and release from nuclear hormone receptors. Genes Dev 13:3209 -3216
    • Nagy L, Kao H-Y, Love JD, LiC, BanayoE,Gooch JT, Chatterjee VKK, Evans RM, Schwabe JWR 1999 Mechanism of corepressor binding and release from nuclear hormone receptors. Genes Dev 13:3209 -3216
  • 59
    • 0033681001 scopus 로고    scopus 로고
    • Gampe Jr RT, Montana VG, Lambert MH, Millaer AB, BledsoeRK, Milburn MV, Kliewer TM, Xu HE 2000 Asymmetry in the PPARγ/RXRα crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. Mol Cell 5:545-555
    • Gampe Jr RT, Montana VG, Lambert MH, Millaer AB, BledsoeRK, Milburn MV, Kliewer TM, Xu HE 2000 Asymmetry in the PPARγ/RXRα crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. Mol Cell 5:545-555
  • 63
    • 33644672013 scopus 로고    scopus 로고
    • Molecular characterization of new selective peroxisome proliferators-activated receptor-γ modulators with an- giotensin receptor blocking activity
    • Schupp M, Clemenz M, Gineste R, Witt H, Janke J, Helleboid S, Hennuyer N, Ruiz P, Unger T, Staels B, Kintscher U 2005 Molecular characterization of new selective peroxisome proliferators-activated receptor-γ modulators with an- giotensin receptor blocking activity. Diabetes 54:3442-3452
    • (2005) Diabetes , vol.54 , pp. 3442-3452
    • Schupp, M.1    Clemenz, M.2    Gineste, R.3    Witt, H.4    Janke, J.5    Helleboid, S.6    Hennuyer, N.7    Ruiz, P.8    Unger, T.9    Staels, B.10    Kintscher, U.11


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