-
1
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
-
Angus DC, Linde-Zwirble WT, Lidicker J, et al: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29:1303-1310
-
(2001)
Crit Care Med
, vol.29
, pp. 1303-1310
-
-
Angus, D.C.1
Linde-Zwirble, W.T.2
Lidicker, J.3
-
2
-
-
0037180768
-
The immunopathogenesis of sepsis
-
Cohen J: The immunopathogenesis of sepsis. Nature 2002; 420:885-891
-
(2002)
Nature
, vol.420
, pp. 885-891
-
-
Cohen, J.1
-
3
-
-
0038578608
-
Novel strategies for the treatment of sepsis
-
Riedemann NC, Guo RF, Ward PA: Novel strategies for the treatment of sepsis. Nat Med 2003; 9:517-524
-
(2003)
Nat Med
, vol.9
, pp. 517-524
-
-
Riedemann, N.C.1
Guo, R.F.2
Ward, P.A.3
-
5
-
-
0034101765
-
Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? A review and a theoretical framework
-
Papathanassoglou ED, Moynihan JA, Ackerman MH: Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? A review and a theoretical framework. Crit Care Med 2000; 28:537-549
-
(2000)
Crit Care Med
, vol.28
, pp. 537-549
-
-
Papathanassoglou, E.D.1
Moynihan, J.A.2
Ackerman, M.H.3
-
6
-
-
0034919862
-
Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome
-
Marshall JC: Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome. Crit Care Med 2001; 29: S99-S106
-
(2001)
Crit Care Med
, vol.29
-
-
Marshall, J.C.1
-
7
-
-
0034892922
-
The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of gram-positive and gram-negative shock
-
Zacharowski K, Berkels R, Olbrich A, et al: The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of gram-positive and gram-negative shock. Crit Care Med 2001; 29:1599-1608
-
(2001)
Crit Care Med
, vol.29
, pp. 1599-1608
-
-
Zacharowski, K.1
Berkels, R.2
Olbrich, A.3
-
8
-
-
0033932898
-
Membrane-permeable radical scavenger, tempol, reduces multiple organ injury in a rodent model of gram-positive shock
-
Zacharowski K, Olbrich A, Cuzzocrea S, et al: Membrane-permeable radical scavenger, tempol, reduces multiple organ injury in a rodent model of gram-positive shock. Crit Care Med 2000; 28:1953-1961
-
(2000)
Crit Care Med
, vol.28
, pp. 1953-1961
-
-
Zacharowski, K.1
Olbrich, A.2
Cuzzocrea, S.3
-
9
-
-
0037611384
-
Cellular apoptosis and organ injury in sepsis: A review
-
Power C, Fanning N, Redmond HP. Cellular apoptosis and organ injury in sepsis: A review. Shock 2002; 18:197-211
-
(2002)
Shock
, vol.18
, pp. 197-211
-
-
Power, C.1
Fanning, N.2
Redmond, H.P.3
-
10
-
-
32444443812
-
Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis
-
Miyoshi N, Oubrahim H, Chock PB, et al: Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Proc Natl Acad Sci USA 2006; 103: 1727-1731
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 1727-1731
-
-
Miyoshi, N.1
Oubrahim, H.2
Chock, P.B.3
-
11
-
-
0343618415
-
Metabolic depletion of ATP by fructose inversely controls CD95- and tumor necrosis factor receptor 1-mediated hepatic apoptosis
-
Latta M, Kunstle G, Leist M, et al: Metabolic depletion of ATP by fructose inversely controls CD95- and tumor necrosis factor receptor 1-mediated hepatic apoptosis. J Exp Med 2000; 191:1975-1985
-
(2000)
J Exp Med
, vol.191
, pp. 1975-1985
-
-
Latta, M.1
Kunstle, G.2
Leist, M.3
-
12
-
-
0036478993
-
The adenine nucleotide translocator in apoptosis
-
Belzacq AS, Vieira HL, Kroemer G, et al: The adenine nucleotide translocator in apoptosis. Biochimie 2002; 84:167-176
-
(2002)
Biochimie
, vol.84
, pp. 167-176
-
-
Belzacq, A.S.1
Vieira, H.L.2
Kroemer, G.3
-
13
-
-
0032566649
-
Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis
-
Marzo I, Brenner C, Zamzami N, et al: Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 1998; 281:2027-2031
-
(1998)
Science
, vol.281
, pp. 2027-2031
-
-
Marzo, I.1
Brenner, C.2
Zamzami, N.3
-
14
-
-
0037039366
-
A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2
-
Krauss S, Zhang CY, Lowell BB. A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proc Natl Acad Sci USA 2002; 99: 118-122
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 118-122
-
-
Krauss, S.1
Zhang, C.Y.2
Lowell, B.B.3
-
15
-
-
0031918742
-
The mitochondrial death/life regulator in apoptosis and necrosis
-
Kroemer G, Dallaporta B, Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol 1998; 60:619-642
-
(1998)
Annu Rev Physiol
, vol.60
, pp. 619-642
-
-
Kroemer, G.1
Dallaporta, B.2
Resche-Rigon, M.3
-
16
-
-
0042415622
-
A function for novel uncoupling proteins: Antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet
-
Goglia F, Skulachev VP. A function for novel uncoupling proteins: Antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet. FASEB J 2003; 17: 1585-1591
-
(2003)
FASEB J
, vol.17
, pp. 1585-1591
-
-
Goglia, F.1
Skulachev, V.P.2
-
17
-
-
0033667705
-
Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
-
Arsenijevic D, Onuma H, Pecqueur C, et al: Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 2000; 26:435-439
-
(2000)
Nat Genet
, vol.26
, pp. 435-439
-
-
Arsenijevic, D.1
Onuma, H.2
Pecqueur, C.3
-
18
-
-
0028999453
-
Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models
-
Leist M, Gantner F, Bohlinger I, et al: Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am J Pathol 1995; 146: 1220-1234
-
(1995)
Am J Pathol
, vol.146
, pp. 1220-1234
-
-
Leist, M.1
Gantner, F.2
Bohlinger, I.3
-
19
-
-
0030044634
-
Apoptotic cell death in the response of d-galactosamine-sensitized mice to lipopolysaccharide as an experimental endotoxic shock model
-
Morikawa A, Sugiyama T, Kato Y, et al: Apoptotic cell death in the response of d-galactosamine-sensitized mice to lipopolysaccharide as an experimental endotoxic shock model. Infect Immun 1996; 64: 734-738
-
(1996)
Infect Immun
, vol.64
, pp. 734-738
-
-
Morikawa, A.1
Sugiyama, T.2
Kato, Y.3
-
20
-
-
0347758631
-
Important role of P-selectin for leukocyte recruitment, hepatocellular injury, and apoptosis in endotoxemic mice
-
Klintman D, Li X, Thorlacius H: Important role of P-selectin for leukocyte recruitment, hepatocellular injury, and apoptosis in endotoxemic mice. Clin Diagn Lab Immunol 2004; 11:56-62
-
(2004)
Clin Diagn Lab Immunol
, vol.11
, pp. 56-62
-
-
Klintman, D.1
Li, X.2
Thorlacius, H.3
-
21
-
-
34447294258
-
Attenuation of inflammation and apoptosis by pre- and posttreatment of darbepoetin-alpha in acute liver failure of mice
-
Le Minh K, Klemm K, Abshagen K, et al: Attenuation of inflammation and apoptosis by pre- and posttreatment of darbepoetin-alpha in acute liver failure of mice. Am J Pathol 2007; 170:1954-1963
-
(2007)
Am J Pathol
, vol.170
, pp. 1954-1963
-
-
Le Minh, K.1
Klemm, K.2
Abshagen, K.3
-
22
-
-
1942487804
-
Impact of leukocytes and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia
-
Eipel C, Bordel R, Nickels RM, et al: Impact of leukocytes and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia. Am J Physiol Gastrointest Liver Physiol 2004; 286:G769-G776
-
(2004)
Am J Physiol Gastrointest Liver Physiol
, vol.286
-
-
Eipel, C.1
Bordel, R.2
Nickels, R.M.3
-
23
-
-
0036246061
-
n-3 Polyunsaturated fatty acid-enriched diet does not protect from liver injury but attenuates mortality rate in a rat model of systemic endotoxemia
-
Vollmar B, Bauer C, Menger MD: n-3 Polyunsaturated fatty acid-enriched diet does not protect from liver injury but attenuates mortality rate in a rat model of systemic endotoxemia. Crit Care Med 2002; 30:1091-1098
-
(2002)
Crit Care Med
, vol.30
, pp. 1091-1098
-
-
Vollmar, B.1
Bauer, C.2
Menger, M.D.3
-
24
-
-
0035958191
-
Fibrinolytic preflush upon liver retrieval from non-heart beating donors to enhance postpreservation viability and energetic recovery upon reperfusion
-
Minor T, Hachenberg A, Tolba R, et al: Fibrinolytic preflush upon liver retrieval from non-heart beating donors to enhance postpreservation viability and energetic recovery upon reperfusion. Transplantation 2001; 71: 1792-1796
-
(2001)
Transplantation
, vol.71
, pp. 1792-1796
-
-
Minor, T.1
Hachenberg, A.2
Tolba, R.3
-
25
-
-
0014353859
-
The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers
-
Atkinson DE: The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. Biochemistry 1968; 7:4030-4034
-
(1968)
Biochemistry
, vol.7
, pp. 4030-4034
-
-
Atkinson, D.E.1
-
27
-
-
0035140552
-
Mechanism of cell death during warm hepatic ischemia-reperfusion in rats: Apoptosis or necrosis?
-
Gujral JS, Bucci TJ, Farhood A, et al: Mechanism of cell death during warm hepatic ischemia-reperfusion in rats: Apoptosis or necrosis? Hepatology 2001; 33:397-405
-
(2001)
Hepatology
, vol.33
, pp. 397-405
-
-
Gujral, J.S.1
Bucci, T.J.2
Farhood, A.3
-
28
-
-
2542559018
-
Improvement of rat liver graft quality by pifithrin-alpha-mediated inhibition of hepatocyte necrapoptosis
-
El-Gibaly AM, Scheuer C, Menger MD, et al: Improvement of rat liver graft quality by pifithrin-alpha-mediated inhibition of hepatocyte necrapoptosis. Hepatology 2004; 39: 1553-1562
-
(2004)
Hepatology
, vol.39
, pp. 1553-1562
-
-
El-Gibaly, A.M.1
Scheuer, C.2
Menger, M.D.3
-
29
-
-
34249672873
-
Antileukoproteinase protects against hepatic inflammation, but not apoptosis in the response of D-galactosamine-sensitized mice to lipopolysaccharide
-
Eipel C, Kidess E, Abshagen K, et al: Antileukoproteinase protects against hepatic inflammation, but not apoptosis in the response of D-galactosamine-sensitized mice to lipopolysaccharide. Br J Pharmacol 2007; 151: 406-413
-
(2007)
Br J Pharmacol
, vol.151
, pp. 406-413
-
-
Eipel, C.1
Kidess, E.2
Abshagen, K.3
-
30
-
-
13844297036
-
Protective effect of dextromethorphan against endotoxic shock in mice
-
Li G, Liu Y, Tzeng NS, et al: Protective effect of dextromethorphan against endotoxic shock in mice. Biochem Pharmacol 2005; 69:233-240
-
(2005)
Biochem Pharmacol
, vol.69
, pp. 233-240
-
-
Li, G.1
Liu, Y.2
Tzeng, N.S.3
-
31
-
-
0842306477
-
The biology of mitochondrial uncoupling proteins
-
Rousset S, Alves-Guerra MC, Mozo J, et al: The biology of mitochondrial uncoupling proteins. Diabetes 2004; 53:S130-S135
-
(2004)
Diabetes
, vol.53
-
-
Rousset, S.1
Alves-Guerra, M.C.2
Mozo, J.3
-
32
-
-
0037469183
-
Protective role of uncoupling protein 2 in atherosclerosis
-
Blanc J, Alves-Guerra MC, Esposito B, et al: Protective role of uncoupling protein 2 in atherosclerosis. Circulation 2003; 107: 388-390
-
(2003)
Circulation
, vol.107
, pp. 388-390
-
-
Blanc, J.1
Alves-Guerra, M.C.2
Esposito, B.3
-
33
-
-
33646508138
-
Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitis
-
Vogler S, Pahnke J, Rousset S, et al: Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitis. Am J Pathol 2006; 168:1570-1575
-
(2006)
Am J Pathol
, vol.168
, pp. 1570-1575
-
-
Vogler, S.1
Pahnke, J.2
Rousset, S.3
-
34
-
-
0042526012
-
Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes
-
Teshima Y, Akao M, Jones SP, et al: Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circ Res 2003; 93:192-200
-
(2003)
Circ Res
, vol.93
, pp. 192-200
-
-
Teshima, Y.1
Akao, M.2
Jones, S.P.3
-
35
-
-
33748918693
-
Lack of UCP2 reduces Fas-mediated liver injury in ob/ob mice and reveals importance of cell-specific UCP2 expression
-
Fulop P, Derdak Z, Sheets A, et al: Lack of UCP2 reduces Fas-mediated liver injury in ob/ob mice and reveals importance of cell-specific UCP2 expression. Hepatology 2006; 44:592-601
-
(2006)
Hepatology
, vol.44
, pp. 592-601
-
-
Fulop, P.1
Derdak, Z.2
Sheets, A.3
-
37
-
-
33644524120
-
Apoptosis and necrosis in the liver: A tale of two deaths?
-
Malhi H, Gores GJ, Lemasters JJ. Apoptosis and necrosis in the liver: A tale of two deaths? Hepatology 2006; 43:S31-S44
-
(2006)
Hepatology
, vol.43
-
-
Malhi, H.1
Gores, G.J.2
Lemasters, J.J.3
-
38
-
-
0030900980
-
Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
-
Leist M, Single B, Castoldi AF, et al: Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis. J Exp Med 1997; 185: 1481-1486
-
(1997)
J Exp Med
, vol.185
, pp. 1481-1486
-
-
Leist, M.1
Single, B.2
Castoldi, A.F.3
-
39
-
-
0037711138
-
Recovery of hepatocellular ATP and "pericentral apoptosis" after hemorrhage and resuscitation
-
Paxian M, Bauer I, Rensing H, et al: Recovery of hepatocellular ATP and "pericentral apoptosis" after hemorrhage and resuscitation. FASEB J 2003; 17:993-1002
-
(2003)
FASEB J
, vol.17
, pp. 993-1002
-
-
Paxian, M.1
Bauer, I.2
Rensing, H.3
-
40
-
-
0032608336
-
-
Lemasters JJV. Necrapoptosis and the mitochondrial permeability transition: Shared pathways to necrosis and apoptosis. Am J Physiol 1999; 27&G1-G6
-
Lemasters JJV. Necrapoptosis and the mitochondrial permeability transition: Shared pathways to necrosis and apoptosis. Am J Physiol 1999; 27&G1-G6
-
-
-
-
41
-
-
0032987412
-
Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: Importance of an intracellular oxidant stress
-
Jaeschke H, Ho YS, Fisher MA, et al: Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: Importance of an intracellular oxidant stress. Hepatology 1999; 29:443-450
-
(1999)
Hepatology
, vol.29
, pp. 443-450
-
-
Jaeschke, H.1
Ho, Y.S.2
Fisher, M.A.3
-
42
-
-
0033646040
-
Mechanisms of ischemic injury are different in the steatotic and normal rat liver
-
Selzner M, Rudiger HA, Sindram D, et al: Mechanisms of ischemic injury are different in the steatotic and normal rat liver. Hepatology 2000; 32:1280-1288
-
(2000)
Hepatology
, vol.32
, pp. 1280-1288
-
-
Selzner, M.1
Rudiger, H.A.2
Sindram, D.3
-
43
-
-
33244466040
-
Warm ischemia-reperfusion injury is decreased by tacrolimus in steatotic rat liver
-
Laurens M, Scozzari G, Patrono D, et al: Warm ischemia-reperfusion injury is decreased by tacrolimus in steatotic rat liver. Liver Transpl 2006; 12:217-225
-
(2006)
Liver Transpl
, vol.12
, pp. 217-225
-
-
Laurens, M.1
Scozzari, G.2
Patrono, D.3
-
44
-
-
0043135016
-
The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity
-
Jaeschke H, Knight TR, Bajt ML: The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. Toxicol Lett 2003; 144:279-288
-
(2003)
Toxicol Lett
, vol.144
, pp. 279-288
-
-
Jaeschke, H.1
Knight, T.R.2
Bajt, M.L.3
-
45
-
-
0034991034
-
Signalling apoptosis: A radical approach
-
Carmody RJ, Cotter TG. Signalling apoptosis: A radical approach. Redox Rep 2001; 6:77-90
-
(2001)
Redox Rep
, vol.6
, pp. 77-90
-
-
Carmody, R.J.1
Cotter, T.G.2
-
46
-
-
0032898080
-
Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver
-
Rashid A, Wu TC, Huang CC, et al: Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. Hepatology 1999; 29:1131-1138
-
(1999)
Hepatology
, vol.29
, pp. 1131-1138
-
-
Rashid, A.1
Wu, T.C.2
Huang, C.C.3
-
47
-
-
33750518197
-
The uncoupling protein 2 modulates the cytokine balance in innate immunity
-
Rousset S, Emre Y, Join-Lambert O, et al: The uncoupling protein 2 modulates the cytokine balance in innate immunity. Cytokine 2006; 35:135-142
-
(2006)
Cytokine
, vol.35
, pp. 135-142
-
-
Rousset, S.1
Emre, Y.2
Join-Lambert, O.3
-
48
-
-
0018664862
-
Adenine nucleotide degradation during energy depletion in human lymphoblasts. Adenosine accumulation and adenylate energy charge correlation
-
Matsumoto SS, Raivio KO, Seegmiller JE: Adenine nucleotide degradation during energy depletion in human lymphoblasts. Adenosine accumulation and adenylate energy charge correlation. J Biol Chem 1979; 254:8956-8962
-
(1979)
J Biol Chem
, vol.254
, pp. 8956-8962
-
-
Matsumoto, S.S.1
Raivio, K.O.2
Seegmiller, J.E.3
-
49
-
-
0028046361
-
Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion
-
Vollmar B, Glasz J, Leiderer R, et al: Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion. Am J Pathol 1994; 145: 1421-1431
-
(1994)
Am J Pathol
, vol.145
, pp. 1421-1431
-
-
Vollmar, B.1
Glasz, J.2
Leiderer, R.3
-
50
-
-
0034104597
-
Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs
-
Masubuchi Y, Yamada S, Horie T: Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther 2000; 292: 982-987
-
(2000)
J Pharmacol Exp Ther
, vol.292
, pp. 982-987
-
-
Masubuchi, Y.1
Yamada, S.2
Horie, T.3
-
51
-
-
0037142987
-
Association between mitochondrial dysfunction and severity and outcome of septic shock
-
Brealey D, Brand M, Hargreaves I, et al: Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002; 360:219-223
-
(2002)
Lancet
, vol.360
, pp. 219-223
-
-
Brealey, D.1
Brand, M.2
Hargreaves, I.3
|