메뉴 건너뛰기




Volumn 37, Issue 1, 2009, Pages 215-222

Uncoupling protein-2 deficiency provides protection in a murine model of endotoxemic acute liver failure

Author keywords

Adenosine triphosphate; Antioxidant; Caspase 3; Microcirculation; Reactive oxygen species

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; CASPASE 3; CYTOKINE; GALACTOSAMINE; LIPOPOLYSACCHARIDE; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; SODIUM CHLORIDE; UNCOUPLING PROTEIN 2; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2;

EID: 59649102837     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31819260ae     Document Type: Article
Times cited : (14)

References (52)
  • 1
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • Angus DC, Linde-Zwirble WT, Lidicker J, et al: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29:1303-1310
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3
  • 2
    • 0037180768 scopus 로고    scopus 로고
    • The immunopathogenesis of sepsis
    • Cohen J: The immunopathogenesis of sepsis. Nature 2002; 420:885-891
    • (2002) Nature , vol.420 , pp. 885-891
    • Cohen, J.1
  • 3
    • 0038578608 scopus 로고    scopus 로고
    • Novel strategies for the treatment of sepsis
    • Riedemann NC, Guo RF, Ward PA: Novel strategies for the treatment of sepsis. Nat Med 2003; 9:517-524
    • (2003) Nat Med , vol.9 , pp. 517-524
    • Riedemann, N.C.1    Guo, R.F.2    Ward, P.A.3
  • 4
    • 0037311807 scopus 로고    scopus 로고
    • Oxidative stress and gene expression in sepsis
    • Macdonald J, Galley HF, Webster NR: Oxidative stress and gene expression in sepsis. Br J Anaesth 2003; 90:221-232
    • (2003) Br J Anaesth , vol.90 , pp. 221-232
    • Macdonald, J.1    Galley, H.F.2    Webster, N.R.3
  • 5
    • 0034101765 scopus 로고    scopus 로고
    • Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? A review and a theoretical framework
    • Papathanassoglou ED, Moynihan JA, Ackerman MH: Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? A review and a theoretical framework. Crit Care Med 2000; 28:537-549
    • (2000) Crit Care Med , vol.28 , pp. 537-549
    • Papathanassoglou, E.D.1    Moynihan, J.A.2    Ackerman, M.H.3
  • 6
    • 0034919862 scopus 로고    scopus 로고
    • Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome
    • Marshall JC: Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome. Crit Care Med 2001; 29: S99-S106
    • (2001) Crit Care Med , vol.29
    • Marshall, J.C.1
  • 7
    • 0034892922 scopus 로고    scopus 로고
    • The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of gram-positive and gram-negative shock
    • Zacharowski K, Berkels R, Olbrich A, et al: The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of gram-positive and gram-negative shock. Crit Care Med 2001; 29:1599-1608
    • (2001) Crit Care Med , vol.29 , pp. 1599-1608
    • Zacharowski, K.1    Berkels, R.2    Olbrich, A.3
  • 8
    • 0033932898 scopus 로고    scopus 로고
    • Membrane-permeable radical scavenger, tempol, reduces multiple organ injury in a rodent model of gram-positive shock
    • Zacharowski K, Olbrich A, Cuzzocrea S, et al: Membrane-permeable radical scavenger, tempol, reduces multiple organ injury in a rodent model of gram-positive shock. Crit Care Med 2000; 28:1953-1961
    • (2000) Crit Care Med , vol.28 , pp. 1953-1961
    • Zacharowski, K.1    Olbrich, A.2    Cuzzocrea, S.3
  • 9
    • 0037611384 scopus 로고    scopus 로고
    • Cellular apoptosis and organ injury in sepsis: A review
    • Power C, Fanning N, Redmond HP. Cellular apoptosis and organ injury in sepsis: A review. Shock 2002; 18:197-211
    • (2002) Shock , vol.18 , pp. 197-211
    • Power, C.1    Fanning, N.2    Redmond, H.P.3
  • 10
    • 32444443812 scopus 로고    scopus 로고
    • Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis
    • Miyoshi N, Oubrahim H, Chock PB, et al: Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Proc Natl Acad Sci USA 2006; 103: 1727-1731
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1727-1731
    • Miyoshi, N.1    Oubrahim, H.2    Chock, P.B.3
  • 11
    • 0343618415 scopus 로고    scopus 로고
    • Metabolic depletion of ATP by fructose inversely controls CD95- and tumor necrosis factor receptor 1-mediated hepatic apoptosis
    • Latta M, Kunstle G, Leist M, et al: Metabolic depletion of ATP by fructose inversely controls CD95- and tumor necrosis factor receptor 1-mediated hepatic apoptosis. J Exp Med 2000; 191:1975-1985
    • (2000) J Exp Med , vol.191 , pp. 1975-1985
    • Latta, M.1    Kunstle, G.2    Leist, M.3
  • 12
    • 0036478993 scopus 로고    scopus 로고
    • The adenine nucleotide translocator in apoptosis
    • Belzacq AS, Vieira HL, Kroemer G, et al: The adenine nucleotide translocator in apoptosis. Biochimie 2002; 84:167-176
    • (2002) Biochimie , vol.84 , pp. 167-176
    • Belzacq, A.S.1    Vieira, H.L.2    Kroemer, G.3
  • 13
    • 0032566649 scopus 로고    scopus 로고
    • Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis
    • Marzo I, Brenner C, Zamzami N, et al: Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 1998; 281:2027-2031
    • (1998) Science , vol.281 , pp. 2027-2031
    • Marzo, I.1    Brenner, C.2    Zamzami, N.3
  • 14
    • 0037039366 scopus 로고    scopus 로고
    • A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2
    • Krauss S, Zhang CY, Lowell BB. A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proc Natl Acad Sci USA 2002; 99: 118-122
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 118-122
    • Krauss, S.1    Zhang, C.Y.2    Lowell, B.B.3
  • 15
    • 0031918742 scopus 로고    scopus 로고
    • The mitochondrial death/life regulator in apoptosis and necrosis
    • Kroemer G, Dallaporta B, Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol 1998; 60:619-642
    • (1998) Annu Rev Physiol , vol.60 , pp. 619-642
    • Kroemer, G.1    Dallaporta, B.2    Resche-Rigon, M.3
  • 16
    • 0042415622 scopus 로고    scopus 로고
    • A function for novel uncoupling proteins: Antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet
    • Goglia F, Skulachev VP. A function for novel uncoupling proteins: Antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet. FASEB J 2003; 17: 1585-1591
    • (2003) FASEB J , vol.17 , pp. 1585-1591
    • Goglia, F.1    Skulachev, V.P.2
  • 17
    • 0033667705 scopus 로고    scopus 로고
    • Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
    • Arsenijevic D, Onuma H, Pecqueur C, et al: Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 2000; 26:435-439
    • (2000) Nat Genet , vol.26 , pp. 435-439
    • Arsenijevic, D.1    Onuma, H.2    Pecqueur, C.3
  • 18
    • 0028999453 scopus 로고
    • Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models
    • Leist M, Gantner F, Bohlinger I, et al: Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am J Pathol 1995; 146: 1220-1234
    • (1995) Am J Pathol , vol.146 , pp. 1220-1234
    • Leist, M.1    Gantner, F.2    Bohlinger, I.3
  • 19
    • 0030044634 scopus 로고    scopus 로고
    • Apoptotic cell death in the response of d-galactosamine-sensitized mice to lipopolysaccharide as an experimental endotoxic shock model
    • Morikawa A, Sugiyama T, Kato Y, et al: Apoptotic cell death in the response of d-galactosamine-sensitized mice to lipopolysaccharide as an experimental endotoxic shock model. Infect Immun 1996; 64: 734-738
    • (1996) Infect Immun , vol.64 , pp. 734-738
    • Morikawa, A.1    Sugiyama, T.2    Kato, Y.3
  • 20
    • 0347758631 scopus 로고    scopus 로고
    • Important role of P-selectin for leukocyte recruitment, hepatocellular injury, and apoptosis in endotoxemic mice
    • Klintman D, Li X, Thorlacius H: Important role of P-selectin for leukocyte recruitment, hepatocellular injury, and apoptosis in endotoxemic mice. Clin Diagn Lab Immunol 2004; 11:56-62
    • (2004) Clin Diagn Lab Immunol , vol.11 , pp. 56-62
    • Klintman, D.1    Li, X.2    Thorlacius, H.3
  • 21
    • 34447294258 scopus 로고    scopus 로고
    • Attenuation of inflammation and apoptosis by pre- and posttreatment of darbepoetin-alpha in acute liver failure of mice
    • Le Minh K, Klemm K, Abshagen K, et al: Attenuation of inflammation and apoptosis by pre- and posttreatment of darbepoetin-alpha in acute liver failure of mice. Am J Pathol 2007; 170:1954-1963
    • (2007) Am J Pathol , vol.170 , pp. 1954-1963
    • Le Minh, K.1    Klemm, K.2    Abshagen, K.3
  • 22
    • 1942487804 scopus 로고    scopus 로고
    • Impact of leukocytes and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia
    • Eipel C, Bordel R, Nickels RM, et al: Impact of leukocytes and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia. Am J Physiol Gastrointest Liver Physiol 2004; 286:G769-G776
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.286
    • Eipel, C.1    Bordel, R.2    Nickels, R.M.3
  • 23
    • 0036246061 scopus 로고    scopus 로고
    • n-3 Polyunsaturated fatty acid-enriched diet does not protect from liver injury but attenuates mortality rate in a rat model of systemic endotoxemia
    • Vollmar B, Bauer C, Menger MD: n-3 Polyunsaturated fatty acid-enriched diet does not protect from liver injury but attenuates mortality rate in a rat model of systemic endotoxemia. Crit Care Med 2002; 30:1091-1098
    • (2002) Crit Care Med , vol.30 , pp. 1091-1098
    • Vollmar, B.1    Bauer, C.2    Menger, M.D.3
  • 24
    • 0035958191 scopus 로고    scopus 로고
    • Fibrinolytic preflush upon liver retrieval from non-heart beating donors to enhance postpreservation viability and energetic recovery upon reperfusion
    • Minor T, Hachenberg A, Tolba R, et al: Fibrinolytic preflush upon liver retrieval from non-heart beating donors to enhance postpreservation viability and energetic recovery upon reperfusion. Transplantation 2001; 71: 1792-1796
    • (2001) Transplantation , vol.71 , pp. 1792-1796
    • Minor, T.1    Hachenberg, A.2    Tolba, R.3
  • 25
    • 0014353859 scopus 로고
    • The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers
    • Atkinson DE: The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. Biochemistry 1968; 7:4030-4034
    • (1968) Biochemistry , vol.7 , pp. 4030-4034
    • Atkinson, D.E.1
  • 27
    • 0035140552 scopus 로고    scopus 로고
    • Mechanism of cell death during warm hepatic ischemia-reperfusion in rats: Apoptosis or necrosis?
    • Gujral JS, Bucci TJ, Farhood A, et al: Mechanism of cell death during warm hepatic ischemia-reperfusion in rats: Apoptosis or necrosis? Hepatology 2001; 33:397-405
    • (2001) Hepatology , vol.33 , pp. 397-405
    • Gujral, J.S.1    Bucci, T.J.2    Farhood, A.3
  • 28
    • 2542559018 scopus 로고    scopus 로고
    • Improvement of rat liver graft quality by pifithrin-alpha-mediated inhibition of hepatocyte necrapoptosis
    • El-Gibaly AM, Scheuer C, Menger MD, et al: Improvement of rat liver graft quality by pifithrin-alpha-mediated inhibition of hepatocyte necrapoptosis. Hepatology 2004; 39: 1553-1562
    • (2004) Hepatology , vol.39 , pp. 1553-1562
    • El-Gibaly, A.M.1    Scheuer, C.2    Menger, M.D.3
  • 29
    • 34249672873 scopus 로고    scopus 로고
    • Antileukoproteinase protects against hepatic inflammation, but not apoptosis in the response of D-galactosamine-sensitized mice to lipopolysaccharide
    • Eipel C, Kidess E, Abshagen K, et al: Antileukoproteinase protects against hepatic inflammation, but not apoptosis in the response of D-galactosamine-sensitized mice to lipopolysaccharide. Br J Pharmacol 2007; 151: 406-413
    • (2007) Br J Pharmacol , vol.151 , pp. 406-413
    • Eipel, C.1    Kidess, E.2    Abshagen, K.3
  • 30
    • 13844297036 scopus 로고    scopus 로고
    • Protective effect of dextromethorphan against endotoxic shock in mice
    • Li G, Liu Y, Tzeng NS, et al: Protective effect of dextromethorphan against endotoxic shock in mice. Biochem Pharmacol 2005; 69:233-240
    • (2005) Biochem Pharmacol , vol.69 , pp. 233-240
    • Li, G.1    Liu, Y.2    Tzeng, N.S.3
  • 31
    • 0842306477 scopus 로고    scopus 로고
    • The biology of mitochondrial uncoupling proteins
    • Rousset S, Alves-Guerra MC, Mozo J, et al: The biology of mitochondrial uncoupling proteins. Diabetes 2004; 53:S130-S135
    • (2004) Diabetes , vol.53
    • Rousset, S.1    Alves-Guerra, M.C.2    Mozo, J.3
  • 32
    • 0037469183 scopus 로고    scopus 로고
    • Protective role of uncoupling protein 2 in atherosclerosis
    • Blanc J, Alves-Guerra MC, Esposito B, et al: Protective role of uncoupling protein 2 in atherosclerosis. Circulation 2003; 107: 388-390
    • (2003) Circulation , vol.107 , pp. 388-390
    • Blanc, J.1    Alves-Guerra, M.C.2    Esposito, B.3
  • 33
    • 33646508138 scopus 로고    scopus 로고
    • Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitis
    • Vogler S, Pahnke J, Rousset S, et al: Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitis. Am J Pathol 2006; 168:1570-1575
    • (2006) Am J Pathol , vol.168 , pp. 1570-1575
    • Vogler, S.1    Pahnke, J.2    Rousset, S.3
  • 34
    • 0042526012 scopus 로고    scopus 로고
    • Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes
    • Teshima Y, Akao M, Jones SP, et al: Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circ Res 2003; 93:192-200
    • (2003) Circ Res , vol.93 , pp. 192-200
    • Teshima, Y.1    Akao, M.2    Jones, S.P.3
  • 35
    • 33748918693 scopus 로고    scopus 로고
    • Lack of UCP2 reduces Fas-mediated liver injury in ob/ob mice and reveals importance of cell-specific UCP2 expression
    • Fulop P, Derdak Z, Sheets A, et al: Lack of UCP2 reduces Fas-mediated liver injury in ob/ob mice and reveals importance of cell-specific UCP2 expression. Hepatology 2006; 44:592-601
    • (2006) Hepatology , vol.44 , pp. 592-601
    • Fulop, P.1    Derdak, Z.2    Sheets, A.3
  • 36
    • 2342529871 scopus 로고    scopus 로고
    • Apoptosis and necrosis in liver disease
    • Jaeschke H, Gujral JS, Bajt ML. Apoptosis and necrosis in liver disease. Liver Int 2004; 24:85-89
    • (2004) Liver Int , vol.24 , pp. 85-89
    • Jaeschke, H.1    Gujral, J.S.2    Bajt, M.L.3
  • 37
    • 33644524120 scopus 로고    scopus 로고
    • Apoptosis and necrosis in the liver: A tale of two deaths?
    • Malhi H, Gores GJ, Lemasters JJ. Apoptosis and necrosis in the liver: A tale of two deaths? Hepatology 2006; 43:S31-S44
    • (2006) Hepatology , vol.43
    • Malhi, H.1    Gores, G.J.2    Lemasters, J.J.3
  • 38
    • 0030900980 scopus 로고    scopus 로고
    • Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
    • Leist M, Single B, Castoldi AF, et al: Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis. J Exp Med 1997; 185: 1481-1486
    • (1997) J Exp Med , vol.185 , pp. 1481-1486
    • Leist, M.1    Single, B.2    Castoldi, A.F.3
  • 39
    • 0037711138 scopus 로고    scopus 로고
    • Recovery of hepatocellular ATP and "pericentral apoptosis" after hemorrhage and resuscitation
    • Paxian M, Bauer I, Rensing H, et al: Recovery of hepatocellular ATP and "pericentral apoptosis" after hemorrhage and resuscitation. FASEB J 2003; 17:993-1002
    • (2003) FASEB J , vol.17 , pp. 993-1002
    • Paxian, M.1    Bauer, I.2    Rensing, H.3
  • 40
    • 0032608336 scopus 로고    scopus 로고
    • Lemasters JJV. Necrapoptosis and the mitochondrial permeability transition: Shared pathways to necrosis and apoptosis. Am J Physiol 1999; 27&G1-G6
    • Lemasters JJV. Necrapoptosis and the mitochondrial permeability transition: Shared pathways to necrosis and apoptosis. Am J Physiol 1999; 27&G1-G6
  • 41
    • 0032987412 scopus 로고    scopus 로고
    • Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: Importance of an intracellular oxidant stress
    • Jaeschke H, Ho YS, Fisher MA, et al: Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: Importance of an intracellular oxidant stress. Hepatology 1999; 29:443-450
    • (1999) Hepatology , vol.29 , pp. 443-450
    • Jaeschke, H.1    Ho, Y.S.2    Fisher, M.A.3
  • 42
    • 0033646040 scopus 로고    scopus 로고
    • Mechanisms of ischemic injury are different in the steatotic and normal rat liver
    • Selzner M, Rudiger HA, Sindram D, et al: Mechanisms of ischemic injury are different in the steatotic and normal rat liver. Hepatology 2000; 32:1280-1288
    • (2000) Hepatology , vol.32 , pp. 1280-1288
    • Selzner, M.1    Rudiger, H.A.2    Sindram, D.3
  • 43
    • 33244466040 scopus 로고    scopus 로고
    • Warm ischemia-reperfusion injury is decreased by tacrolimus in steatotic rat liver
    • Laurens M, Scozzari G, Patrono D, et al: Warm ischemia-reperfusion injury is decreased by tacrolimus in steatotic rat liver. Liver Transpl 2006; 12:217-225
    • (2006) Liver Transpl , vol.12 , pp. 217-225
    • Laurens, M.1    Scozzari, G.2    Patrono, D.3
  • 44
    • 0043135016 scopus 로고    scopus 로고
    • The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity
    • Jaeschke H, Knight TR, Bajt ML: The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. Toxicol Lett 2003; 144:279-288
    • (2003) Toxicol Lett , vol.144 , pp. 279-288
    • Jaeschke, H.1    Knight, T.R.2    Bajt, M.L.3
  • 45
    • 0034991034 scopus 로고    scopus 로고
    • Signalling apoptosis: A radical approach
    • Carmody RJ, Cotter TG. Signalling apoptosis: A radical approach. Redox Rep 2001; 6:77-90
    • (2001) Redox Rep , vol.6 , pp. 77-90
    • Carmody, R.J.1    Cotter, T.G.2
  • 46
    • 0032898080 scopus 로고    scopus 로고
    • Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver
    • Rashid A, Wu TC, Huang CC, et al: Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. Hepatology 1999; 29:1131-1138
    • (1999) Hepatology , vol.29 , pp. 1131-1138
    • Rashid, A.1    Wu, T.C.2    Huang, C.C.3
  • 47
    • 33750518197 scopus 로고    scopus 로고
    • The uncoupling protein 2 modulates the cytokine balance in innate immunity
    • Rousset S, Emre Y, Join-Lambert O, et al: The uncoupling protein 2 modulates the cytokine balance in innate immunity. Cytokine 2006; 35:135-142
    • (2006) Cytokine , vol.35 , pp. 135-142
    • Rousset, S.1    Emre, Y.2    Join-Lambert, O.3
  • 48
    • 0018664862 scopus 로고
    • Adenine nucleotide degradation during energy depletion in human lymphoblasts. Adenosine accumulation and adenylate energy charge correlation
    • Matsumoto SS, Raivio KO, Seegmiller JE: Adenine nucleotide degradation during energy depletion in human lymphoblasts. Adenosine accumulation and adenylate energy charge correlation. J Biol Chem 1979; 254:8956-8962
    • (1979) J Biol Chem , vol.254 , pp. 8956-8962
    • Matsumoto, S.S.1    Raivio, K.O.2    Seegmiller, J.E.3
  • 49
    • 0028046361 scopus 로고
    • Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion
    • Vollmar B, Glasz J, Leiderer R, et al: Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion. Am J Pathol 1994; 145: 1421-1431
    • (1994) Am J Pathol , vol.145 , pp. 1421-1431
    • Vollmar, B.1    Glasz, J.2    Leiderer, R.3
  • 50
    • 0034104597 scopus 로고    scopus 로고
    • Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs
    • Masubuchi Y, Yamada S, Horie T: Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther 2000; 292: 982-987
    • (2000) J Pharmacol Exp Ther , vol.292 , pp. 982-987
    • Masubuchi, Y.1    Yamada, S.2    Horie, T.3
  • 51
    • 0037142987 scopus 로고    scopus 로고
    • Association between mitochondrial dysfunction and severity and outcome of septic shock
    • Brealey D, Brand M, Hargreaves I, et al: Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002; 360:219-223
    • (2002) Lancet , vol.360 , pp. 219-223
    • Brealey, D.1    Brand, M.2    Hargreaves, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.