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Volumn 28, Issue 6, 2000, Pages 1953-1961

Membrane-permeable radical scavenger, tempol, reduces multiple organ injury in a rodent model of Gram-positive shock

Author keywords

Anesthetized rat; Gram positive shock; Lipoteichoic acid; Oxygen radicals; Peptidoglycan; Superoxide anions; Superoxide dismutase; Tempol

Indexed keywords

LIPOTEICHOIC ACID; NITRATE; NITRITE; PEPTIDOGLYCAN; SCAVENGER; SUPEROXIDE; SUPEROXIDE DISMUTASE; TEMPOL;

EID: 0033932898     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200006000-00044     Document Type: Article
Times cited : (26)

References (52)
  • 1
    • 0028040319 scopus 로고
    • Gram-positive organisms and sepsis
    • 1. Bone RC: Gram-positive organisms and sepsis. Arch Intern Med 1994; 154:26-34
    • (1994) Arch Intern Med , vol.154 , pp. 26-34
    • Bone, R.C.1
  • 2
    • 0025738836 scopus 로고
    • Southwestern Internal Medicine Conference: Septic shock
    • 2. Nogare AR: Southwestern Internal Medicine Conference: Septic shock. Am J Med Sci 1991; 302:50-65
    • (1991) Am J Med Sci , vol.302 , pp. 50-65
    • Nogare, A.R.1
  • 3
    • 0024575208 scopus 로고
    • Role of endotoxemia in cardiovascular dysfunction and mortality: Escherichia coli and Staphylococcus aureus challenges in a canine model of human septic shock
    • 3. Natanson C, Danner RL, Elin RJ, et al: Role of endotoxemia in cardiovascular dysfunction and mortality: Escherichia coli and Staphylococcus aureus challenges in a canine model of human septic shock. Clin Invest 1989; 83:243-251
    • (1989) Clin Invest , vol.83 , pp. 243-251
    • Natanson, C.1    Danner, R.L.2    Elin, R.J.3
  • 4
    • 0026093615 scopus 로고
    • Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia: Comparison to Escherichia coli
    • 4. Wakabayashi G, Gelfand JA, Jung WK, et al: Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia: Comparison to Escherichia coli. J Clin Invest 1991; 87:1925-1935
    • (1991) J Clin Invest , vol.87 , pp. 1925-1935
    • Wakabayashi, G.1    Gelfand, J.A.2    Jung, W.K.3
  • 5
    • 0023800594 scopus 로고
    • Physiology of lipoteichoic acids in bacteria
    • 5. Fischer W: Physiology of lipoteichoic acids in bacteria. Adv Microb Physiol 1988; 29: 233-302
    • (1988) Adv Microb Physiol , vol.29 , pp. 233-302
    • Fischer, W.1
  • 6
    • 0028824813 scopus 로고
    • The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure
    • 6. De Kimpe SJ, Kengatharan M, Thiemermann C, et al: The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure. Proc Natl Acad Sci U S A 1995; 92:10359-10363
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 10359-10363
    • De Kimpe, S.J.1    Kengatharan, M.2    Thiemermann, C.3
  • 7
    • 0031821974 scopus 로고    scopus 로고
    • Mechanism of gram-positive shock: Identification of peptidoglycan and lipoteichoic acid moieties essential in the induction of nitric oxide synthase, shock, and multiple organ failure
    • 7. Kengatharan KM, De Kimpe S, Robson C, et al: Mechanism of gram-positive shock: Identification of peptidoglycan and lipoteichoic acid moieties essential in the induction of nitric oxide synthase, shock, and multiple organ failure. Exp Med 1998; 188:305-315
    • (1998) Exp Med , vol.188 , pp. 305-315
    • Kengatharan, K.M.1    De Kimpe, S.2    Robson, C.3
  • 8
    • 0023111152 scopus 로고
    • Neutrophil function in a rat model of endotoxin-induced lung injury
    • 8. Simons RK, Maier RV, Lennards ES: Neutrophil function in a rat model of endotoxin-induced lung injury. Arch Surg 1987; 122: 197-203
    • (1987) Arch Surg , vol.122 , pp. 197-203
    • Simons, R.K.1    Maier, R.V.2    Lennards, E.S.3
  • 9
    • 0027212837 scopus 로고
    • Longitudinal analysis of neutrophil superoxide anion generation in patients with septic shock
    • 9. Vespasiona MC, Lewandoski JR, Zimmerman JJ: Longitudinal analysis of neutrophil superoxide anion generation in patients with septic shock. Crit Care Med 1993; 21:666-672
    • (1993) Crit Care Med , vol.21 , pp. 666-672
    • Vespasiona, M.C.1    Lewandoski, J.R.2    Zimmerman, J.J.3
  • 10
    • 0024458315 scopus 로고
    • Spin trapping of free radicals produced "in vivo" in heart and liver during endotoxemia
    • 10. Brackett DJ, Lai EK, Lerner MR, et al: Spin trapping of free radicals produced "in vivo" in heart and liver during endotoxemia. Free Radic Res Commun 1989; 7:315-324
    • (1989) Free Radic Res Commun , vol.7 , pp. 315-324
    • Brackett, D.J.1    Lai, E.K.2    Lerner, M.R.3
  • 11
    • 0025189864 scopus 로고
    • Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
    • 11. Beckman JS, Beckman TW, Chen J, et al: Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A 1990; 87:1620-1624
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 1620-1624
    • Beckman, J.S.1    Beckman, T.W.2    Chen, J.3
  • 12
    • 0031033903 scopus 로고    scopus 로고
    • The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock
    • 12. Zingarelli B, Day BJ, Crapo JD, et al: The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock. Br J Pharmacol 1997; 120: 259-267
    • (1997) Br J Pharmacol , vol.120 , pp. 259-267
    • Zingarelli, B.1    Day, B.J.2    Crapo, J.D.3
  • 13
    • 0031438451 scopus 로고    scopus 로고
    • Role of free radicals in septic shock
    • 13. Novelli GP: Role of free radicals in septic shock. J Physiol Pharmacol 1997; 48: 517-527
    • (1997) J Physiol Pharmacol , vol.48 , pp. 517-527
    • Novelli, G.P.1
  • 14
    • 0022633277 scopus 로고
    • Oxidant activity in expired breath of patients with adult respiratory distress syndrome
    • 14. Baldwin SR, Simon RH, Grum CM, et al: Oxidant activity in expired breath of patients with adult respiratory distress syndrome. Lancet 1986; i:11-14
    • (1986) Lancet , vol.1 , pp. 11-14
    • Baldwin, S.R.1    Simon, R.H.2    Grum, C.M.3
  • 15
    • 0024464651 scopus 로고
    • Increased hydrogen peroxide in the expired breath of patients with acute hypoxemic respiratory failure
    • 15. Sznajder JI, Fraiman A, Hall JB, et al: Increased hydrogen peroxide in the expired breath of patients with acute hypoxemic respiratory failure. Chest 1989; 96:606-612
    • (1989) Chest , vol.96 , pp. 606-612
    • Sznajder, J.I.1    Fraiman, A.2    Hall, J.B.3
  • 17
    • 0023073281 scopus 로고
    • Inhibition of lipid peroxidation improves survival rate of endotoxemic rats
    • 17. Kunimoto F, Morita T, Ogawa R, et al: Inhibition of lipid peroxidation improves survival rate of endotoxemic rats. Circ Shock 1987; 21:15-22
    • (1987) Circ Shock , vol.21 , pp. 15-22
    • Kunimoto, F.1    Morita, T.2    Ogawa, R.3
  • 18
    • 0024326325 scopus 로고
    • Protection by recombinant human superoxide dismutase in lethal rat endotoxemia
    • 18. Schneider J, Friderichs E, Giertz H: Protection by recombinant human superoxide dismutase in lethal rat endotoxemia. Prog Clin Biol Res 1989; 308:913-917
    • (1989) Prog Clin Biol Res , vol.308 , pp. 913-917
    • Schneider, J.1    Friderichs, E.2    Giertz, H.3
  • 19
    • 0022749279 scopus 로고
    • Effect of allopurinol and superoxide dismutase in rats with sepsis
    • 19. Warner BW, Hasselgren PO, Fischer JE: Effect of allopurinol and superoxide dismutase in rats with sepsis. Curr Surg 1986; 43: 292-293
    • (1986) Curr Surg , vol.43 , pp. 292-293
    • Warner, B.W.1    Hasselgren, P.O.2    Fischer, J.E.3
  • 20
    • 0024469951 scopus 로고
    • Effect of antioxidants in experimental Escherichia coli septicemia
    • 20. Broner CW, Shenep JL, Stidham GL, et al: Effect of antioxidants in experimental Escherichia coli septicemia. Circ Shock 1989; 29: 77-92
    • (1989) Circ Shock , vol.29 , pp. 77-92
    • Broner, C.W.1    Shenep, J.L.2    Stidham, G.L.3
  • 21
    • 0022445713 scopus 로고
    • Modification by oxygen free radical scavengers of the metabolic and cardiovascular effects of endotoxin infusion in conscious rats
    • 21. McKechnie K, Furman BL, Parratt JR: Modification by oxygen free radical scavengers of the metabolic and cardiovascular effects of endotoxin infusion in conscious rats. Circ Shock 1986; 19:429-439
    • (1986) Circ Shock , vol.19 , pp. 429-439
    • McKechnie, K.1    Furman, B.L.2    Parratt, J.R.3
  • 22
    • 0023897692 scopus 로고
    • Evidence for lack of importance of oxygen free radicals in Escherichia coli endotoxemia in dogs
    • 22. Novotny MJ, Laughlin MH, Adams HR: Evidence for lack of importance of oxygen free radicals in Escherichia coli endotoxemia in dogs. Am J Physiol 1988; 254:H954-H962
    • (1988) Am J Physiol , vol.254
    • Novotny, M.J.1    Laughlin, M.H.2    Adams, H.R.3
  • 23
    • 0023571251 scopus 로고
    • Effect of polyethylene glycol-superoxide dismutase and catalase on endotoxemia in pigs
    • 23. Olson NC, Grizzle MK, Anderson DL: Effect of polyethylene glycol-superoxide dismutase and catalase on endotoxemia in pigs. J Appl Physiol 1987; 63:1526-1532
    • (1987) J Appl Physiol , vol.63 , pp. 1526-1532
    • Olson, N.C.1    Grizzle, M.K.2    Anderson, D.L.3
  • 24
    • 0025030018 scopus 로고
    • SOD in rat models of shock and organ failure
    • 24. Redl H, Lieners C, Bahrami S, et al: SOD in rat models of shock and organ failure. Adv Exp Med Biol 1990; 264:17-27
    • (1990) Adv Exp Med Biol , vol.264 , pp. 17-27
    • Redl, H.1    Lieners, C.2    Bahrami, S.3
  • 25
    • 0021864571 scopus 로고
    • Potentiation of lung vascular response to endotoxin by superoxide dismutase
    • 25. Traber DL, Adams T, Sziebert L. et al: Potentiation of lung vascular response to endotoxin by superoxide dismutase. J Appl Physiol 1985; 58:1005-1009
    • (1985) J Appl Physiol , vol.58 , pp. 1005-1009
    • Traber, D.L.1    Adams, T.2    Sziebert, L.3
  • 26
    • 0027383809 scopus 로고
    • Free radicals and antioxidants in sepsis
    • 26. Goode HF, Webster NR: Free radicals and antioxidants in sepsis. Crit Care Med 1993; 21:1770-1776
    • (1993) Crit Care Med , vol.21 , pp. 1770-1776
    • Goode, H.F.1    Webster, N.R.2
  • 27
    • 0025285382 scopus 로고
    • Copper, zinc superoxide dismutase catalyses hydroxyl radical production from hydrogen peroxide
    • 27. Yim MB, Chock PB, Stadtman ER: Copper, zinc superoxide dismutase catalyses hydroxyl radical production from hydrogen peroxide. Proc Natl Acad Sci U S A 1990; 87:5006-5010
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 5006-5010
    • Yim, M.B.1    Chock, P.B.2    Stadtman, E.R.3
  • 28
    • 0029053451 scopus 로고
    • Superoxide radical and superoxide dismutases
    • 28. Fridovich I: Superoxide radical and superoxide dismutases. Annu Rev Biochem 1995; 64: 97-112
    • (1995) Annu Rev Biochem , vol.64 , pp. 97-112
    • Fridovich, I.1
  • 29
    • 0024792041 scopus 로고
    • Endotoxin-induced mortality in rats is reduced by nitrones
    • 29. Hamburger SA, McCay PB: Endotoxin-induced mortality in rats is reduced by nitrones. Circ Shock 1989; 29:329-334
    • (1989) Circ Shock , vol.29 , pp. 329-334
    • Hamburger, S.A.1    McCay, P.B.2
  • 30
    • 0026637297 scopus 로고
    • Oxygen-radicals in experimental shock: Effects of spin-trapping nitrones in ameliorating shock pathophysiology
    • 30. Novelli GP: Oxygen-radicals in experimental shock: Effects of spin-trapping nitrones in ameliorating shock pathophysiology. Crit Care Med 1992; 20:499-507
    • (1992) Crit Care Med , vol.20 , pp. 499-507
    • Novelli, G.P.1
  • 31
    • 0022939066 scopus 로고
    • Phenyl-T-butyl-nitrone is active against traumatic shock in rats
    • 31. Novelli GP, Angiolini P, Tani R, et al: Phenyl-T-butyl-nitrone is active against traumatic shock in rats. Free Radic Res Commun 1986; 1:321-327
    • (1986) Free Radic Res Commun , vol.1 , pp. 321-327
    • Novelli, G.P.1    Angiolini, P.2    Tani, R.3
  • 32
  • 33
    • 0031727611 scopus 로고    scopus 로고
    • Decline in the expression of copper/zinc superoxide dismutase in the kidney of rats with endotoxic shock: Effects of the superoxide anion radical scavenger, tempol, on organ injury
    • 33. Leach M, Frank S, Olbrich A, et al: Decline in the expression of copper/zinc superoxide dismutase in the kidney of rats with endotoxic shock: Effects of the superoxide anion radical scavenger, tempol, on organ injury. Br J Pharmacol 1998; 125:817-825
    • (1998) Br J Pharmacol , vol.125 , pp. 817-825
    • Leach, M.1    Frank, S.2    Olbrich, A.3
  • 34
    • 0028882178 scopus 로고
    • Protective effect of 4-hydroxy-TEMPO, a low molecular weight superoxide dismutase mimic, on free radical toxicity in experimental pancreatitis
    • 34. Sledzinski Z, Wozniak M, Antosiewicz J, et al: Protective effect of 4-hydroxy-TEMPO, a low molecular weight superoxide dismutase mimic, on free radical toxicity in experimental pancreatitis. Int J Pancreatol 1995; 18: 153-160
    • (1995) Int J Pancreatol , vol.18 , pp. 153-160
    • Sledzinski, Z.1    Wozniak, M.2    Antosiewicz, J.3
  • 35
    • 0002241145 scopus 로고
    • The multiple organ or system failure syndrome
    • Schlag G, Redl H (Eds). Berlin, Springer Verlag
    • 35. Baue AE: The multiple organ or system failure syndrome. In: Pathophysiology of Shock, Sepsis, and Organ Failure. Schlag G, Redl H (Eds). Berlin, Springer Verlag, 1993, pp 1004-1018
    • (1993) Pathophysiology of Shock, Sepsis, and Organ Failure , pp. 1004-1018
    • Baue, A.E.1
  • 36
    • 0027729864 scopus 로고
    • Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury
    • 36. Hewett JA, Jean PA, Kunkel SL, et al: Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury. Am J Physiol 1993; 265: G1011-G1015
    • (1993) Am J Physiol , vol.265
    • Hewett, J.A.1    Jean, P.A.2    Kunkel, S.L.3
  • 37
    • 0030986711 scopus 로고    scopus 로고
    • Effect of calpain inhibitor 1, an inhibitor of the proteolysis of 1 kappa B, on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat
    • 37. Ruetten H, Thiemermann C: Effect of calpain inhibitor 1, an inhibitor of the proteolysis of 1 kappa B, on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat. Br J Pharmacol 1997; 121: 695-704
    • (1997) Br J Pharmacol , vol.121 , pp. 695-704
    • Ruetten, H.1    Thiemermann, C.2
  • 38
    • 0028799424 scopus 로고
    • The multiple organ dysfunction syndrome caused by endotoxin in the rat: Attenuation of liver dysfunction by inhibitors of nitric oxide synthase
    • 38. Thiemermann C, Ruetten H, Wu CC, et al: The multiple organ dysfunction syndrome caused by endotoxin in the rat: Attenuation of liver dysfunction by inhibitors of nitric oxide synthase. Br J Pharmacol 1995; 116: 2845-2851
    • (1995) Br J Pharmacol , vol.116 , pp. 2845-2851
    • Thiemermann, C.1    Ruetten, H.2    Wu, C.C.3
  • 39
    • 0027066985 scopus 로고
    • Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages
    • 39. Schmidt HH, Warner TD, Nakane M, et al: Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages. Mol Pharmacol 1992; 41:615-624
    • (1992) Mol Pharmacol , vol.41 , pp. 615-624
    • Schmidt, H.H.1    Warner, T.D.2    Nakane, M.3
  • 41
    • 0031975261 scopus 로고    scopus 로고
    • Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation
    • 41. Cuzzocrea S, Zingarelli B, Hake P, et al: Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation. Free Radic Biol Med 1998; 24:450-459
    • (1998) Free Radic Biol Med , vol.24 , pp. 450-459
    • Cuzzocrea, S.1    Zingarelli, B.2    Hake, P.3
  • 42
    • 0345196633 scopus 로고    scopus 로고
    • Beneficial effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (Mntbap), a superoxide dismutase mimetic, in carrageenpleurisy
    • 42. Cuzzocrea S, Zingarelli B, Costantino G, et al: Beneficial effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (Mntbap), a superoxide dismutase mimetic, in carrageenpleurisy. Free Radic Biol Med 1999; 26:25-33
    • (1999) Free Radic Biol Med , vol.26 , pp. 25-33
    • Cuzzocrea, S.1    Zingarelli, B.2    Costantino, G.3
  • 43
    • 0032584164 scopus 로고    scopus 로고
    • Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase
    • 43. Szabo C, Virag L, Cuzzocrea S, et al: Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase. Proc Natl Acad Sci U S A 1998; 95:3867-3872
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 3867-3872
    • Szabo, C.1    Virag, L.2    Cuzzocrea, S.3
  • 44
    • 0032057735 scopus 로고    scopus 로고
    • Oxidation, tyrosine nitration and cytostasis induction in the absence of inducible nitric oxide synthase
    • 44. Zingarelli B, Virag L, Szabo A, et al: Oxidation, tyrosine nitration and cytostasis induction in the absence of inducible nitric oxide synthase. Int J Mol Med 1998; 1:787-795
    • (1998) Int J Mol Med , vol.1 , pp. 787-795
    • Zingarelli, B.1    Virag, L.2    Szabo, A.3
  • 46
    • 0029788363 scopus 로고    scopus 로고
    • Protective effect of the nitroxide tempol against the cardiotoxicity of Adriamycin
    • 46. Monti E, Cova D, Guido E, et al: Protective effect of the nitroxide tempol against the cardiotoxicity of Adriamycin. Free Radic Biol Med 1996; 21:463-470
    • (1996) Free Radic Biol Med , vol.21 , pp. 463-470
    • Monti, E.1    Cova, D.2    Guido, E.3
  • 48
    • 0032556905 scopus 로고    scopus 로고
    • Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
    • 48. Eiserich JP, Hristova M, Cross CE, et al: Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature 1998; 391:393-397
    • (1998) Nature , vol.391 , pp. 393-397
    • Eiserich, J.P.1    Hristova, M.2    Cross, C.E.3
  • 49
    • 0025881720 scopus 로고
    • Cardiac reperfusion damage prevented by a nitroxide free radical
    • 49. Gelvan D, Saltman P, Powell SR: Cardiac reperfusion damage prevented by a nitroxide free radical. Proc Natl Acad Sci U S A 1991; 88:4680-4684
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 4680-4684
    • Gelvan, D.1    Saltman, P.2    Powell, S.R.3
  • 50
    • 0030769908 scopus 로고    scopus 로고
    • Nitroxides increase the detectable amount of nitric oxide released from endothelial cells
    • 50. Zöllner S, Haseloff RF, Kirilyuk IA, et al: Nitroxides increase the detectable amount of nitric oxide released from endothelial cells. J Biol Chem 1997; 272:23076-23080
    • (1997) J Biol Chem , vol.272 , pp. 23076-23080
    • Zöllner, S.1    Haseloff, R.F.2    Kirilyuk, I.A.3
  • 51
    • 0032059870 scopus 로고    scopus 로고
    • Selective inhibition of the activity of inducible nitric oxide synthase prevents the circulatory failure, but not the organ injury/dysfunction, caused by endotoxin
    • 51. Wray GM, Millar CG, Hinds CJ, et al: Selective inhibition of the activity of inducible nitric oxide synthase prevents the circulatory failure, but not the organ injury/dysfunction, caused by endotoxin. Shock 1998; 9:329-335
    • (1998) Shock , vol.9 , pp. 329-335
    • Wray, G.M.1    Millar, C.G.2    Hinds, C.J.3
  • 52
    • 0031032290 scopus 로고    scopus 로고
    • Optimal time and dosage of phenyl N-tert-butyl nitrone (PBN) for the inhibition of nitric oxide synthase induction in mice
    • 52. Miyajima T, Kotake Y: Optimal time and dosage of phenyl N-tert-butyl nitrone (PBN) for the inhibition of nitric oxide synthase induction in mice. Free Radic Biol Med 1997; 22:463-470
    • (1997) Free Radic Biol Med , vol.22 , pp. 463-470
    • Miyajima, T.1    Kotake, Y.2


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