Classical PKC is not associated with defective insulin signaling in patients with impaired glucose tolerance

Diabetes Research and Clinical Practice

Volumn 83, Issue 3, 2009, Pages 334-340

  Kim, Do Min ^b   Jang, Hyun Ju ^a   Han, Seung Jin ^a   Ha, Eun Suk ^a   Kim, Yun Kyung ^a   Park, Jee Won ^a   Song, Kyoung Eun ^a   Jung, Sun Hye ^a   Ahn, Sang Mi ^a   Choi, Sung E ^a   Kim, Hae Jin ^a   Kim, Dae Jung ^a   Lee, Hyun Chul ^c   Lee, Kwan Woo ^a  

^a Ajou University School of Medicine   (South Korea)

^b Hanil General Hospital   (South Korea)

^c Yonsei University College of Medicine   (South Korea)

Author keywords

Impaired glucose tolerance (IGT); Insulin resistance; Insulin signaling

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR BETA; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C LAMBDA; PROTEIN KINASE C THETA; PROTEIN KINASE C ZETA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE INFUSION; GLUCOSE TRANSPORT; HUMAN; HUMAN TISSUE; IMPAIRED GLUCOSE TOLERANCE; MALE; MUSCLE BIOPSY; PROTEIN PHOSPHORYLATION; VASTUS LATERALIS MUSCLE;

ADULT; BIOPSY; BLOOD GLUCOSE; CHOLESTEROL, HDL; CHOLESTEROL, LDL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; GLYCOGEN SYNTHASE KINASE 3; HUMANS; HYPERINSULINISM; INSULIN; INSULIN RESISTANCE; MALE; MUSCLE, SKELETAL; PROTEIN KINASE C; REFERENCE VALUES; SIGNAL TRANSDUCTION;

EID: 59349095031     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2008.11.035     Document Type: Article

References (35)

1. De fronzo R.A., and Prato S.D. Insulin resistance and diabetes mellitus. J. Diabetes Complications 10 (1996) 243-245
2. Marrett A., Burdett E., Douen A., Vranic M., and Klip A. Insulin induces the translocation of the GLUT4 from a unique intracellular organelle to the transverse tubles in rat skeletal muscle. Diabetes 41 (1992) 1562-1569
3. Munoz P., Rosenblatt M., Testar X., Palacin M., Thoidis G., Pilch P.F., et al. The t-tuble is cell surface target for insulin-regulated recycling of membrane proteins in skeletal muscle. J. Biol. Chem. 312 (1995) 393-400
4. Ploug T., van Deurs B., Ai H., Cushman S.W., and Ralston E. Analysis of GLUT4 distribution in whole skeletal muscle fibers: identification of distinct storage compartments that are reduced by insulin and muscle contractions. J. Cell Biol. 142 (1998) 1429-1446
5. Virkamaki A., Ueki K., Zhu J.H., Brecjtel-Hook G., Wallace P., and Baron A.D. Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle from patients with NIDDM. Diabetologia 39 (1996) 1180-1189
6. Okada T., Kawano Y., Sakakibara T., Hazeki O., and Ui M. Essential role of phosphatidylinositol 3-kinase in insulin-stimulated glucose transport and antilipolysis in rat adipocytes: studies with selective inhibitor wortmannin. J. Biol. Chem. 269 (1994) 3568-3573
7. Kim Y.B., Nikoulina S.E., Ciaraldi T.P., Henry R.R., and Kahn B.B. Normal insulin dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositol 3-kinase, in muscle in type 2 diabetes. J. Clin. Invest. 104 (1999) 733-741
8. Vollenweider P., Menard B., and Nicod P. Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3′ kinase activation, and impaired atypical protein kinase C [(zeta)/(lambda)] activation in myotubes from obese patients with impaired glucose tolerance. Diabetes 51 (2002) 1052-1059
9. Cross D.A., Alessi D.R., Cohen P., Andjelkovichi M., and Hemmings B.A. Inhibition of glycogen synthesis kinase-3 by insulin mediated by protein kinase B. Nature 378 (1995) 785-789
10. Eldar-Finkelman H., and Krebs E.G. Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impaires insulin action. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 9660-9664
11. Ishizuka T., Cooper D.R., and Farese R.W. Insulin stimulates the translocation of protein kinase C in rat adipocytes. FEBS Lett. 257 (1989) 337-340
12. Walaas S.I., Horn R.S., Adler A., Albert K.A., and Walaas O. Insulin increases membrane protein kinase C activity in rat diaphragm. FEBS Lett. 220 (1987) 311-318
13. Cooper D.R., Hernandez H., Kuo J.Y., and Farese R.V. Insulin increases the synthesis of phospholipid and diacylglycerol and protein kinase C activity in rat hepatocytes. Arch. Biochem. Biophys. 276 (1990) 486-494
14. Kim Y.B., Shulman G.I., and Kahn B.B. Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda/zeta but not on glycogen synthase kinase-3. J. Biol. Chem. 277 (2002) 32915-32922
15. Itani S.I., Zhou Q., Pories W., MacDonald K.G., and Dohm L. Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity. Diabetes 49 (2000) 1353-1358
16. Choi J.H., Lee K.W., Kim H.J., Lee D.H., Kim J.Y., and Lim H.C. Impaired metabolic signal transduction networks in isolated skeletal muscle in Korean type 2 diabetic patients. Korean J. Endocrinol. 17 (2002) 555-567
17. DeFronzo R.A., Tobin J.D., and Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol. 237 (1979) E214-223
18. Zierath J.R., He L., Guma A., Odegoard Wahlstrom E., Klip A., and Wallberg-Henri-ksson H. Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM. Diabetologia 39 (1996) 1180-1189
19. Zierath J.R., Houseknecht K.L., and Kahn B.B. Glucose transports and diabetes. Semin. Cell Dev. Biol. 7 (1996) 295-307
20. Carey J.O., Azevedo Jr. J., Morris P.G., Pories W.J., and Dohm G.L. Okadaic acid, vanadate, and phenylarsine oxide stimulate 2-deoxyglucose transport in insulin-resistant human skeletal muscle. Diabetes 44 (1995) 682-688
21. Kotani K., Ogawa W., Matsumoto M., Kitamura T., Sakaue H., and Hino Y. Requirement of atypical protein kinase C lambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes. Mol. Cell. Biol. 18 (1998) 6971-6982
22. Standaert M.L., Galloway L., Karnam P., Bandyopadhyay G., Moscat J., and Farese R.V. Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes: potential role in glucose transport. J. Biol. Chem. 272 (1997) 30075-30082
23. Bandyopadhyay G., Kanoh Y., Sajan M.P., Standaeert M.L., and Farese R.V. Effects of adenoviral gene transfer of wild-type constitutively active, and kinase-defective protein kinase C-lambda on insulin-stimulated glucose transport in L6 myotubes. Endocrinology 141 (2000) 4120-4127
24. Kohn A.D., Kovacina K.S., and Roth R.A. Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase. EMBO J. 14 (1995) 4288-4295
25. Burgering B.M.T., and Coffer P.J. Protein kinase B(c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376 (1995) 599-602
26. Didichenko S.A., Tilton B., Hemmings B.A., Ballmer-Hofer K., and Thelen M. Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane targeted phosphoinositide 3-kinase. Curr. Biol. 6 (1996) 1271-1278
27. Krook A., Roth R.A., Jiang X.J., Zierath J.R., and Wallberg-Henriksson H. Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from non-insulin-dependent diabetic subjects. Diabetes 47 (1998) 1281-1286
28. Nikoulina S.E., Ciaraldi T.P., Mudaliar S., Mohideen P., Carter L., and henry R.R. Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes. Diabetes 49 (2000) 263-271
29. Kim Y.B., Kotani K., Ciaraldi T.P., Henry R.R., and Kahn B.B. Insulin-stimulated protein kinase C lamda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes. Diabetes 52 (2003) 1935-1942
30. Beeson M., Sajan M.P., Dizon M., Grebenev D., Gomez-Daspet J., Miura A., et al. Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise. Diabetes 52 (2003) 1926-1934
31. Yamada K., Avignon A., Standaert M.L., Cooper D.R., Spencer B., and Farese R.V. Effects of insulin on the translocation of protein kinase C-theta and other protein kinase C isoforms in rat skeletal muscles. Biochem. J. 308 (1995) 177-180
32. Avignon A., Standaert M.L., Yamada K., Mischak H., Spencer B., and Farese R.V. Insulin increases mRNA levels of protein kinase C-alpha and -beta in rat adipocytes and protein kinase C-alpha, -beta and -theta in rat skeletal muscle. Biochem. J. 308 (1995) 181-187
33. Griffin M.E., Marcucci M.J., Cline G.W., Bell K., Barucci N., Lee D., et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 48 (1999) 1270-1274
34. Bandyopadhyay G.K., Yu J.G., Ofrecio J., and Olefsky J.M. Increased p85/55/50 expression and decreased phosphatidylinositol 3-kinase activity in insulin-resistant human skeletal muscle. Diabetes 54 (2005) 2351-2359
35. Schmitz-Peiffer C., Browne C.L., Oakes N.D., Watkinson A., Chisholm D.J., Kraegen E.W., et al. Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. Diabetes 46 (1997) 169-178