The in vitro and in ovo responses of chickens to TLR9 subfamily ligands

Developmental and Comparative Immunology

Volumn 33, Issue 5, 2009, Pages 660-667

  Jenkins, Kristie A ^a   Lowenthal, John W ^a   Kimpton, Wayne ^b   Bean, Andrew G D ^a  

^a CSIRO   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Chicken; In ovo administration; TLR9 subfamily; Toll like receptors

Indexed keywords

BACTERIAL DNA; CPG OLIGODEOXYNUCLEOTIDE; INTERFERON; INTERLEUKIN 6; LIGAND; LOXORIBINE; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOASSAY; CELL MATURATION; CELL PROLIFERATION; CHICKEN; CONTROLLED STUDY; CYTOKINE PRODUCTION; EMBRYO; EMBRYO DEVELOPMENT; ENDOSOME; FIBROBLAST; IMMUNOMODULATION; IN VITRO STUDY; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; SPLEEN CELL;

GALLUS GALLUS; MAMMALIA; SPONDIAS PURPUREA;

EID: 59349091237     PISSN: 0145305X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dci.2008.11.009     Document Type: Article

References (59)

1. Medzhitov R., Preston-Hurlburt P., and Janeway C.A.J. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388 (1997) 394-397
2. Beutler B. The Toll-like receptors: analysis by forward genetic methods. Immunogenetics 57 (2005) 385-392
3. Takeda K., Kaisho T., and Akira S. Toll-like receptors. Annu Rev Immunol 21 (2003) 335-376
4. Chuang T.H., and Ulevitch R.J. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur Cytokine Netw 11 (2000) 372-378
5. Du X., Poltorak A., Wei Y., and Beutler B. Three novel mammalian toll-like receptors: gene structure, expression, and evolution. Eur Cytokine Netw 11 (2000) 362-371
6. Heil F., Ahmad-Nejad P., Hemmi H., Hochrein H., Ampenberger F., Gellert T., et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7 8 and 9 subfamily. Eur J Immunol 33 (2003) 2987-2997
7. Nishiya T., and DeFranco A.L. Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J Biol Chem 279 (2004) 19008-19017
8. Takeda K., and Akira S. Toll-like receptors in innate immunity. Int Immunol 17 (2005) 1-14
9. Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol 1 (2001) 135-145
10. Diebold S.S., Kaisho T., Hemmi H., Akira S., and Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303 (2004) 1529-1531
11. Heil F., Hemmi H., Hochrein H., Ampenberger F., Kirschning C., Akira S., et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303 (2004) 1526-1529
12. Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., et al. A Toll-like receptor recognizes bacterial DNA. Nature 408 (2000) 740-745
13. Krieg A.M. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 20 (2002) 709-760
14. Barton G.M., and Medzhitov R. Toll-like receptors and their ligands. Curr Top Microbiol Immunol 270 (2002) 81-92
15. Wagner H. Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity. Curr Opin Microbiol 5 (2002) 62-69
16. Sparwasser T., Koch E.S., Vabulas R.M., Heeg K., Lipford G.B., Ellwart J.W., et al. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol 28 (1998) 2045-2054
17. Ito S., Ishii K.J., Ihata A., and Klinman D.M. Contribution of nitric oxide to CpG-mediated protection against Listeria monocytogenes. Infect Immun 73 (2005) 3803-3805
18. Karaca K., Sharma J.M., Tomai M.A., and Miller R.L. In vivo and in vitro interferon induction in chickens by S-28828, an imidazoquinolinamine immunoenhancer. J Interferon Cytokine Res 16 (1996) 327-332
19. He H., Crippen T.L., Farnell M.B., and Kogut M.H. Identification of CpG oligodeoxynucleotide motifs that stimulate nitric oxide and cytokine production in avian macrophage and peripheral blood mononuclear cells. Dev Comp Immunol 27 (2003) 621-627
20. Iqbal M., Philbin V.J., and Smith A.L. Expression patterns of chicken Toll-like receptor mRNA in tissues, immune cell subsets and cell lines. Vet Immunol Immunopathol 104 (2005) 117-127
21. Roach J.C., Glusman G., Rowen L., Kaur A., Purcell M.K., Smith K.D., et al. The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci USA 102 (2005) 9577-9582
22. Yilmaz A., Shen S., Adelson D.L., Xavier S., and Zhu J.J. Identification and sequence analysis of chicken Toll-like receptors. Immunogenetics 56 (2005) 743-753
23. Boyd Y., Goodchild M., Morroll S., and Bumstead N. Mapping of the chicken and mouse genes for toll-like receptor 2 (TLR2) to an evolutionarily conserved chromosomal segment. Immunogenetics 52 (2001) 294-298
24. Philbin V.J., Iqbal M., Boyd Y., Goodchild M.J., Beal R.K., Bumstead N., et al. Identification and characterization of a functional, alternatively spliced Toll-like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens. Immunology 114 (2005) 507-521
25. Smith J., Speed D., Law A.S., Glass E.J., and Burt D.W. In-silico identification of chicken immune-related genes. Immunogenetics 56 (2004) 122-133
26. Higgs R., Cormican P., Cahalane S., Allan B., Lloyd A.T., Meade K., et al. Induction of a novel chicken Toll-like receptor following Salmonella enterica serovar Typhimurium infection. Infect Immun 74 (2006) 1692-1698
27. Pechumer H., Leinisch E., Bender-Gotze C., and Ziegler-Heitbrock H.W. Recovery of monocytes after bone marrow transplantation-rapid reappearance of tumor necrosis factor alpha and interleukin 6 production. Transplantation 52 (1991) 698-704
28. Schneider K., Klaas R., Kaspers B., and Staeheli P. Chicken interleukin-6. cDNA structure and biological properties. Eur J Biochem 268 (2001) 4200-4206
29. Janardhana V., Ford M.E., Bruce M.P., Broadway M.M., O'Neil T.E., Karpala A.J., et al. IFN-gamma enhances immune responses to E. coli infection in the chicken. J Interferon Cytokine Res 27 (2007) 937-946
30. Lowenthal J.W., Digby M.R., and York J.J. Production of interferon-gamma by chicken T cells. J Interferon Cytokine Res 15 (1995) 933-938
31. Lowenthal J.W., York J.J., O'Neil T.E., Rhodes S., Prowse S.J., Strom D.G., et al. In vivo effects of chicken interferon-gamma during infection with Eimeria. J Interferon Cytokine Res 17 (1997) 551-558
32. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408
33. Pope B.L., Chourmouzis E., Victorino L., MacIntyre J.P., Capetola R.J., and Lau C.Y. Loxoribine (7-allyl-8-oxoguanosine) activates natural killer cells and primes cytolytic precursor cells for activation by IL-2. J Immunol 151 (1993) 3007-3017
34. Ito T., Amakawa R., Kaisho T., Hemmi H., Tajima K., Uehira K., et al. Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J Exp Med 195 (2002) 1507-1512
35. Xie H., Raybourne R.B., Babu U.S., Lillehoj H.S., and Heckert R.A. CpG-induced immunomodulation and intracellular bacterial killing in a chicken macrophage cell line. Dev Comp Immunol 27 (2003) 823-834
36. Kogut M.H., Iqbal M., He H., Philbin V., Kaiser P., and Smith A. Expression and function of Toll-like receptors in chicken heterophils. Dev Comp Immunol 29 (2005) 791-807
37. Chow J.C., Young D.W., Golenbock D.T., Christ W.J., and Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 274 (1999) 10689-10692
38. Klinman D.M., Yi A.K., Beaucage S.L., Conover J., and Krieg A.M. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc Natl Acad Sci USA 93 (1996) 2879-2883
39. Zhang Y., Shoda L.K., Brayton K.A., Estes D.M., Palmer G.H., and Brown W.C. Induction of interleukin-6 and interleukin-12 in bovine B lymphocytes, monocytes, and macrophages by a CpG oligodeoxynucleotide (ODN 2059) containing the GTCGTT motif. J Interferon Cytokine Res 21 (2001) 871-881
40. Chu R.S., Targoni O.S., Krieg A.M., Lehmann P.V., and Harding C.V. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med 186 (1997) 1623-1631
41. Davis H.L., Weeratna R., Waldschmidt T.J., Tygrett L., Schorr J., and Krieg A.M. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J Immunol 160 (1998) 870-876
42. Ahmad-Nejad P., Hacker H., Rutz M., Bauer S., Vabulas R.M., and Wagner H. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur J Immunol 32 (2002) 1958-1968
43. He H., and Kogut M.H. CpG-ODN-induced nitric oxide production is mediated through clathrin-dependent endocytosis, endosomal maturation, and activation of PKC, MEK1/2 and p38 MAPK, and NF-kappaB pathways in avian macrophage cells (HD11). Cell Signal 15 (2003) 911-917
44. Gomis S., Babiuk L., Allan B., Willson P., Waters E., Hecker R., et al. Protection of chickens against a lethal challenge of Escherichia coli by a vaccine containing CpG oligodeoxynucleotides as an adjuvant. Avian Dis 51 (2007) 78-83
45. Linghua Z., Xingshan T., and Fengzhen Z. Vaccination with Newcastle disease vaccine and CpG oligodeoxynucleotides induces specific immunity and protection against Newcastle disease virus in SPF chicken. Vet Immunol Immunopathol 115 (2007) 216-222
46. Van Damme J., Schaafsma M.R., Fibbe W.E., Falkenburg J.H., Opdenakker G., and Billiau A. Simultaneous production of interleukin 6, interferon-beta and colony-stimulating activity by fibroblasts after viral and bacterial infection. Eur J Immunol 19 (1989) 163-168
47. Kopf M., Baumann H., Freer G., Freudenberg M., Lamers M., Kishimoto T., et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368 (1994) 339-342
48. Harrison C.J., Jenski L., Voychehovski T., and Bernstein D.I. Modification of immunological responses and clinical disease during topical R-837 treatment of genital HSV-2 infection. Antiviral Res 10 (1988) 209-223
49. Patel B.A., Gomis S., Dar A., Willson P.J., Babiuk L.A., Potter A., et al. Oligodeoxynucleotides containing CpG motifs (CpG-ODN) predominantly induce Th1-type immune response in neonatal chicks. Dev Comp Immunol 32 (2008) 1041-1049
50. Emlen W., and Mannik M. Effect of DNA size and strandedness on the in vivo clearance and organ localization of DNA. Clin Exp Immunol 56 (1984) 185-192
51. Jochemsen P., and Jeurissen S.H. The localization and uptake of in ovo injected soluble and particulate substances in the chicken. Poult Sci 81 (2002) 1811-1817
52. Klinman D.M., Conover J., and Coban C. Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection. Infect Immun 67 (1999) 5658-5663
53. Gomis S., Babiuk L., Godson D.L., Allan B., Thrush T., Townsend H., et al. Protection of chickens against Escherichia coli infections by DNA containing CpG motifs. Infect Immun 71 (2003) 857-863
54. Rautenschlein S., Miller R.L., and Sharma J.M. The inhibitory effect of the imidazoquinolinamine S-28828 on the pathogenesis of a type II adenovirus in turkeys. Antiviral Res 46 (2000) 195-205
55. Schlaepfer E., Audige A., Joller H., and Speck R.F. TLR7/8 triggering exerts opposing effects in acute versus latent HIV infection. J Immunol 176 (2006) 2888-2895
56. He H., Genovese K.J., Swaggerty C.L., Nisbet D.J., and Kogut M.H. In vivo priming heterophil innate immune functions and increasing resistance to Salmonella enteritidis infection in neonatal chickens by immune stimulatory CpG oligodeoxynucleotides. Vet Immunol Immunopathol 117 (2007) 275-283
57. He H., Lowry V.K., Swaggerty C.L., Ferro P.J., and Kogut M.H. In vitro activation of chicken leukocytes and in vivo protection against Salmonella enteritidis organ invasion and peritoneal S. enteritidis infection-induced mortality in neonatal chickens by immunostimulatory CpG oligodeoxynucleotide. FEMS Immunol Med Microbiol 43 (2005) 81-89
58. Dalloul R.A., Lillehoj H.S., Okamura M., Xie H., Min W., Ding X., et al. In vivo effects of CpG oligodeoxynucleotide on Eimeria infection in chickens. Avian Dis 48 (2004) 783-790
59. Dalloul R.A., Lillehoj H.S., Klinman D.M., Ding X., Min W., Heckert R.A., et al. In ovo administration of CpG oligodeoxynucleotides and the recombinant microneme protein MIC2 protects against Eimeria infections. Vaccine 23 (2005) 3108-3113