Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects: A cross-sectional study

Journal of Neurology

Volumn 254, Issue 12, 2007, Pages 1676-1683

  Klepac, N ^a   Relja, M ^a   Klepac, R ^b   Hecimovic S ^c   Babic T ^a   Trkulja, V ^b  

^a KBC Zagreb   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

Huntington's disease; Lipid peroxidation; Oxidative stress; Reduced glutathione; Unified Huntington's Disease Rating Scale (UHDRS)

Indexed keywords

GLUTATHIONE;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DNA DETERMINATION; FEMALE; HETEROZYGOTE; HUMAN; HUNTINGTON CHOREA; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; SEX; STATISTICAL SIGNIFICANCE;

ADULT; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; GLUTATHIONE PEROXIDASE; HUMANS; HUNTINGTON DISEASE; LIPID PEROXIDATION; LIPIDS; MALE; MIDDLE AGED; OXIDATIVE STRESS; PLASMA; STATISTICS, NONPARAMETRIC; TRINUCLEOTIDE REPEAT EXPANSION; VERBAL BEHAVIOR;

EID: 37749000434     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-007-0611-y     Document Type: Article

References (33)

1. Albers DS, Beal MF (2000) Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. J Neural Transm 59:133-154
2. Andersen JK (2004) Oxidative stress in neurodegeneration: cause or consequence? Nat Med 10:18-25
3. Bates G (2003) Huntingtin aggregation and toxicity in Huntington's disease. Lancet 361:1642-1644
4. Beal MF (2000) Mechanisms of cell death in neurodegenerative disorders. Eur J Neurol 7 (Suppl. 2):1-4
5. Browne SE, Ferrante RJ, Beal MF (1999) Oxidative stress in Huntington's disease. Brain Pathol 9:147-163
6. Brouillet E, Jacquard C, Bizat N, Blum D (2005) 3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease. J Neurochem 95:1521-1540
7. Butterfield DA,Kanski J (2001) Brain protein oxidation in age-related neurodegenerative disorder that are associated with aggregated proteins. Mech Ageing Dev 122:945-962
8. Christofiades J, Bridel M, Egerton M, Mackay GM, Forrest CM, Stoy N, Darlington LG, Stone TW (2006) Blood 5-hydroxytryptamine, 5-hydroxyindoleacetic acid and melatonin levels in patients with either Huntington's disease or chronic brain injury. J Neurochem 97:1078-1088
9. Delanty N, Dichter MA (2000) Antioxidant therapy in neurological diseases. Arch Neurol 57:1265-1270
10. Dringen R,Hirrlinger J (2003) Glutathione pathways in the brain. Biol Chem 384:505-516
11. Feigin A, Zgaljardic D (2002) Recent advances in Huntington's disease: implications for experimental therapeutics. Curr Opin Neurol 15:483-489
12. Hague SM,Klaffke S, Bandmann O (2005) Neurodegenerative disorders: Parkinson's disease and Huntington's disease. J Neurol Neurosurg Psychiatry 76:1058-1063
13. Hećimović S, Klepac N, Vlašić J,Vojta A, Janko D, Škarpa-Prpić I, Canki- Klain N,Marković D, Božikov J, Relja M, Pavelić K (2002) Genetic background of Huntington disease in Croatia:Molecular analysis of CAG, CCG, and Delta2642 (E2642del) polymorphisms. Hum Mutat 20:233
14. del Hoyo P, Garcia-Redondo A, de Bustos F,Molina JA, Sayed Y, Alonso-Navarro H, Caballero L, Arenas J, Jimenez-Jimenez FJ (2006) Oxidative stress in skin fibroblasts cultures of patients with Huntington's disease. Neurochem Res 31:1103-1109
15. Huntington's Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosome. Cell 72: 971-983
16. Huntington Study Group (1996) Unified Huntington's disease rating scale: reliability and consistency. Mov Disord 11:136-142
17. Inoue M, Koyama K (1994) Determination of superoxide and vitamine C radicals using cytochrome c and superoxide dismutase derivatives. Methods Enzymol 56:338-343
18. Johansson LH, Borg LA (1988) A spectrophotometric method for determination of catalase activity in small tissue samples. Anal Biochem 174:331-336
19. Lang C,Naryshin S, Schneider DL, Mills BJ, Linderman RD (1992) Low blood glutathione levels in healthy aging adult. J Lab Clin Med 20:720-725
20. Levine RL, Gardland D, Olivier CN, Amici A, Climent I, Lenz AG, Ahn BW, Shaltiel S, Stadtman ER (1990) Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 186:464-478
21. Lowry OH, Rosebrough NJ, Farr AL, Randall LJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:263-275
22. Mariani E, Polidori MC, Cherubini A, Mecocci P (2005) Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J Chromatogr B Analyt Technol Biomed Life Sci 827:65-75
23. Marklund S,Marklund G (1974) Involvement of the superoxide anion radical in the antioxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47:469-474
24. Myers RH (2004) Huntington's disease genetics. NeuroRx 1:255-262
25. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxidases in animal tissue by thiobarbituric acid reaction. Annal Biochem 95:351-358
26. Perez-Severiano F, Rios C, Segovia J (2000) Striatal oxidative damage parallels the expression of a neurological phenotype in mice transgenic for the mutation of Huntington's disease. Brain Res 862:234-237
27. Santamaria A, Perez-Severiano F, Rodriquez-Martinez E, Maldonado PD, Pedraza-Chaverri J, Rios C, Segovia J (2001) Comparative analysis of superoxide dismutase activity between acute pharmacological models and transgenic mouse model of Huntington's disease. Neurchem Res 26:419-424
28. Sian J, Dexter DT, Lees AJ, Daniel S, Agid Y, Javoy-Agid F, Jenner P,Marsden CD (1994) Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Ann Neurol 36:348-355
29. Stoy N, Mackay GM, Forrest CM, Christofides J, Egerton M, Stone TW, Darlington LG (2005) Tryptophan metabolism and oxidative stress in patients with Huntington's disease. J Neurochem 93:611-623
30. Taiq M, Khan HA, Elfaki I, Al Deeb S, Al Moutaery K (2005) Neuroprotective effect of nicotine against 3-nitropropionic acid (3-NP)-induced experimental Huntington's disease in rats. Brain Res Bull 67:161-168
31. Tarpey MM; Fridovich I (2001) Methods of detection of vascular reactive species: nitric oxide, superoxide, hydrogen peroxide and peroxynitrite. Circ Res 89:224-236
32. Warner JP, Barron LH, Brock DJH (1993) A new polymerase chain reaction (PCR) assay for the trinucleotide repeat that is unstable and expanded on Huntington's disease chromosomes. Molecular Cellular Probes 7:235-239
33. Zoghbi HY, Orr HT (2000) Glutamine repeats and neurodegeneration. Annu Rev Neurosci 23:217-247