Mouse 3-Phosphoinositide-dependent Protein Kinase-1 Undergoes Dimerization and trans-Phosphorylation in the Activation Loop

Journal of Biological Chemistry

Volumn 278, Issue 44, 2003, Pages 42913-42919

  Wick, Michael J ^a   Ramos, Fresnida J ^a   Chen, Hui ^c   Quon, Michael J ^c   Dong, Lily Q ^b   Liu, Feng ^a,b  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL ACTIVATION; DIMERIZATION; ENZYMES; FLUORESCENCE; PHOSPHORUS COMPOUNDS;

ACTIVATION LOOP;

BIOCHEMISTRY;

3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; INSULIN RECEPTOR; PHOSPHATIDYLINOSITIDE; PHOSPHOAMINO ACID; PHOSPHOPEPTIDE; PROTEIN KINASE; SERINE; THREONINE; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN;

AMINO ACID ANALYSIS; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHO CELL; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; NONHUMAN; PRIORITY JOURNAL; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CHO CELLS; CRICETINAE; DIMERIZATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUTATHIONE TRANSFERASE; INSULIN; MICE; MODELS, GENETIC; MUTAGENESIS, SITE-DIRECTED; PHOSPHOAMINO ACIDS; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SERINE; THREONINE;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0242384929     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304172200     Document Type: Article

References (23)

1. Toker, A., and Newton, A. C. (2000) Cell 103, 185-188
2. Wick, K. L. R., and Liu, F. (2001) Curr. Drug Targets: Immune, Endocr. Metab. Disorders 1, 209-211
3. Chen, H., Nystrom, F. H., Dong, L. Q., Li, Y., Song, S., Liu, F., and Quon, M. J. (2001) Biochemistry 40, 11851-11859
4. Grillo, S., Gremeaux, T., Casamayor, A., Alessi, D. R., Le Marchand-Brustel, Y., and Tanti, J. F. (2000) Eur. J. Biochem. 267, 6642-6649
5. Park, J., Hill, M. M., Hess, D., Brazil, D. P., Hofsteenge, J., and Hemmings, B. A. (2001) J. Biol. Chem. 276, 37459-37471
6. Dong, L. Q., Ramos, F. J., Wick, M. J., Lim, M. A., Guo, Z. M., Strong, R., Richardson, A., and Liu, F. (2002) Biochem. Biophys. Res. Commun. 294, 136-144
7. Casamayor, A., Morrice, N. A., and Alessi, D. R. (1999) Biochem. J. 342, 287-292
8. Wick, M. J., Dong, L. Q., Riojas, R. A., Ramos, F., and Liu, F. (2000) J. Biol. Chem. 275, 40400-40406
9. Frodin, M., Jensen, C. J., Merienne, K., and Gammeltoft, S. (2000) EMBO J. 19, 2924-2934
10. Dong, L. Q., Zhang, L.-B., Langlais, P., He, H., Clark, M., Zhu, L., and Liu, F. (1999) J. Biol. Chem. 274, 8117-8122
11. Wick, M. J., Wick, K. R., Chen, H., He, H., Dong, L. Q., Quon, M. J., and Liu, F. (2002) J. Biol. Chem. 277, 16632-16638
12. Kunkel, T. A., Roberts, J. D., and Zakour, R. A. (1987) Methods Enzymol. 154, 367-383
13. Wick, M. J., Dong, L. Q., Hu, D., Langlais, P., and Liu, F. (2001) J. Biol. Chem., 275, 42843-42850
14. Johnson, L. N., Noble, M. E. M., and Owen, D. J. (1996) Cell 85, 149-158
15. Prowse, C. N., and Lew, J. (2001) J. Biol. Chem. 276, 99-103
16. Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., and Cohen, P. (1997) Curr. Biol. 7, 261-269
17. Alessi, D. R., Deak, M., Casamayor, A., Caudwell, F. B., Morrice, N., Norman, D. G., Gaffney, P., Reese, C. B., MacDougall, C. N., Harbison, D., Ashworth, A., and Bownes, M. (1997) Curr. Biol. 7, 776-789
18. Biondi, R. M., Cheung, P. C., Casamayor, A., Deak, M., Currie, R. A., and Alessi, D. R. (2000) EMBO J. 19, 979-988
19. Balendran, A., Biondi, R. M., Cheung, P. C., Casamayor, A., Deak, M., and Alessi, D. R. (2000) J. Biol. Chem. 275, 20806-20813
20. Ziegler, W. H., Parekh, D. B., Le Good, J. A., Whelan, R. D., Kelly, J. J., Frech, M., Hemmings, B. A., and Parker, P. J. (1999) Curr. Biol. 9, 522-529
21. Frodin, M., Antal, T. L., Dummler, B. A., Jensen, C. J., Deak, M., Gammeltoft, S., and Biondi, R. M. (2002) EMBO J. 21, 5396-5407
22. Parekh, D. B., Ziegler, W., and Parker, P. J. (2000) EMBO J. 19, 496-503
23. Storz, P., and Toker, A. (2002) Front Biosci. 7, d886-902