Nanoparticles of cationic chimeric peptide and sodium polyacrylate exhibit striking antinociception activity at lower dose

Journal of Controlled Release

Volumn 134, Issue 1, 2009, Pages 47-54

  Gupta, Kshitij ^a,c   Singh, Vijay P ^a   Kurupati, Raj K ^a   Mann, Anita ^a   Ganguli, Munia ^a   Gupta, Yogendra K ^b   Singh, Yogendra ^a   Saleem, Kishwar ^c   Pasha, Santosh ^a   Maiti, Souvik ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^c JAMIA MILLIA ISLAMIA CENTRAL UNIVERSITY   (India)

Author keywords

Antinociception; Chimeric peptide; Cytotoxicity; Hematological parameters; Nanoparticles

Indexed keywords

AFM; ANTINOCICEPTION; CATIONIC PEPTIDES; CHARGE RATIOS; CHIMERIC PEPTIDE; CONTROL GROUPS; DELIVERY SYSTEMS; HEMATOLOGICAL PARAMETERS; IN-VITRO; MAMMALIAN CELL LINES; MTT ASSAYS; PEPTIDE RELEASE; POLYELECTROLYTE COMPLEXES; POSITIVE SURFACE CHARGES; PROTEOLYTIC DEGRADATIONS; SODIUM POLYACRYLATES;

AMINES; ANIMAL CELL CULTURE; BIOCHEMISTRY; CATALYST ACTIVITY; CELL CULTURE; CYTOTOXICITY; DYES; MAMMALS; POLYMERS; ZETA POTENTIAL;

NANOPARTICLES;

CHIMERIC PROTEIN; NANOPARTICLE; POLYACRYLATE SODIUM; POLYACRYLIC ACID; TYROSYLGLYCYLGLYCYLPHENYLALANYLMETHIONYLLYSYLLYSYLLYSYLPHENYLALANYLMETHIONYLARGINYLPHENYLALANINAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG STRUCTURE; HUMAN; HUMAN CELL; LOW DRUG DOSE; MALE; MICROMORPHOLOGY; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN SECRETION; SUSTAINED DRUG RELEASE; TAIL FLICK TEST; ZETA POTENTIAL;

ACRYLIC RESINS; ANALGESICS; ANIMALS; CATIONS; CELL LINE; MAMMALS; MICE; NANOPARTICLES; PEPTIDES; TAIL;

EID: 59049093067     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.10.008     Document Type: Article

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