15-HETE suppresses K+ channel activity and inhibits apoptosis in pulmonary artery smooth muscle cells

Apoptosis

Volumn 14, Issue 1, 2009, Pages 42-51

  Li, Yumei ^a   Li, Qian ^a   Wang, Zhigang ^a   Liang, Di ^a   Liang, Shujun ^a   Tang, Xiaobo ^b   Guo, Lei ^a   Zhang, Rong ^a   Zhu, Daling ^a,b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Biopharmaceutical Key Laboratory of Heilongjiang Province   (China)

Author keywords

15 Hydroxyeicosatetraenoic acid; Apoptosis; Hypoxia induced pulmonary hypertension; K+ channel; Pulmonary artery muscle smooth cells

Indexed keywords

15 HYDROXY 5,8,11,13 ICOSATETRAENOIC ACID; 15-HYDROXY-5,8,11,13-EICOSATETRAENOIC ACID; ARACHIDONIC ACID; CASPASE 3; HYDROGEN PEROXIDE; HYDROXYICOSATETRAENOIC ACID; POTASSIUM; POTASSIUM CHANNEL; PROTEIN BCL 2; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE; UNCLASSIFIED DRUG;

ANOXIA; APOPTOSIS; ARTICLE; BIOLOGICAL MODEL; CHEMISTRY; HUMAN; METABOLISM; MITOCHONDRION; PATHOLOGY; PULMONARY ARTERY; SMOOTH MUSCLE FIBER;

ANOXIA; APOPTOSIS; ARACHIDONIC ACID; CASPASE 3; HUMANS; HYDROGEN PEROXIDE; HYDROXYEICOSATETRAENOIC ACIDS; MITOCHONDRIA; MODELS, BIOLOGICAL; MYOCYTES, SMOOTH MUSCLE; POTASSIUM; POTASSIUM CHANNELS; PROTO-ONCOGENE PROTEINS C-BCL-2; PULMONARY ARTERY; TETRAZOLIUM SALTS; THIAZOLES;

EID: 58949101334     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-008-0286-6     Document Type: Article

References (27)

1. Pak O, Aldashev A, Welsh D, Peacock A (2007) The effects of hypoxia on the cells of the pulmonary vasculature. Eur Respir J 30(2):364-372. doi:10.1183/09031936.00128706 (Pubitemid 47201724)
2. Stenmark KR, Fagan KA, Frid MG (2006) Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms. Circ Res 99(7):675-691. doi:10.1161/01.RES.0000243 584.45145.3f (Pubitemid 44498302)
3. Zhu D, Medhora M, Campbell WB, Spitzbarth N, Baker JE, Jacobs ER (2002) Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries. Circ Res 92:992. doi:10.1161/01.RES.0000070881.65194.8F
4. Setty BN, Graeber JE, Stuart MJ (1987) The mitogenic effect of 15- and 12-hydroxyeicosatetraenoic acid on endothelial cells may be mediated via diacylglycerol kinase inhibition. J Biol Chem 262(36):17613-17622 (Pubitemid 18032247)
5. Gulbins E, Jekle A, Ferlinz K, Grassmé H, Lang F (2000) Physiology of apoptosis. Am J Physiol Renal Physiol 279(4): F605-F615
6. Preston IR, Hill NS, Warburton RR, Fanburg BL (2006) Role of 12-lipoxygenase in hypoxia-induced rat pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol 290:L367-L374. doi:10.1152/ajplung.00114.2005
7. Schultz K, Fanurg BL, Beasley D (2006) Hypoxia and hypoxiainducible factor-1{alpha} promotes growth factor-induced proliferation of human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 290:H2528-H2534. doi:10.1152/ajpheart. 01077.2005 (Pubitemid 43846084)
8. Geraci MW, Moore M, Gesell T, Yeager M, Alger L, Golpon H et al (2001) Gene expression patterns in the lungs of patients with primary pulmonary hypertension: a gene microarray analysis. Circ Res 88:555-562 (Pubitemid 32275790)
9. Morrell NW, Yang X, Upton PD, Jourdan KB, Morgan N, Sheares KK, Trembath RC (2001) Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth. Circulation 104(7):790-795. doi:10.1161/hc3201.094152 (Pubitemid 32762677)
10. Krick S, Platoshyn O, Sweeney M, McDaniel SS, Zhang S, Rubin LJ, Yuan JX (2002) Nitric oxide induces apoptosis by activating K? channels in pulmonary vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 282(1):H184-H193 (Pubitemid 34654149)
11. Li Q, Zhang R, Lü CL, Liu Y, Wang Z, Zhu DL (2006) The role of subtypes of voltage-gated K? channel in pulmonary vasoconstriction induced by 15-hydroeicosatetraenoic acid. Yao Xue Xue Bao 41(5):412-417 (Pubitemid 44022664)
12. Moudgil R, Michelakis ED, Archer SL (2006) The role of K? channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension. Microcirculation 13(8):615-632 (Pubitemid 44696118)
13. Krick S, Platoshyn O, Sweeney M, Kim H, Yuan JX (2001) Activation of K? channels induces apoptosis in vascular smooth muscle cells. Am J Physiol Cell Physiol 280:C970-C979
14. Platoshyn O, Remillard CV, Fantozzi I, Mandegar M, Sison TT, Zhang S, Burg E, Yuan JX (2004) Diversity of voltage-dependent K? channels in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 287(1):L226-L238 (Pubitemid 38787670)
15. Remillard V, Yuan JX-J (2004) Activation of K? channels: an essential pathway in programmed cell death Carmelle V. Am J Physiol Lung Cell Mol Physiol 286:L49-L67 (Pubitemid 38055858)
16. Zhang S, Fantozzi I, Tigno DD, Yi ES, Platoshyn O, Thistlethwaite PA, Kriett JM, Yung G, Rubin LJ, Yuan JX (2003) Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 285(3):L740-L754 (Pubitemid 37022876)
17. Mauban JR, Remillard CV, Yuan JX (2005) Hypoxic pulmonary vasoconstriction: role of ion channels. Jappl Physiol 98:415-420 (Pubitemid 40041275)
18. Yuan X-J (1995) Voltage-gated K? currents regulate resting membrane potential and [Ca2?]i in pulmonary arterial myocytes. Circ Res 77:370-378
19. Han W, Tang X, Wu H, Liu Y, Zhu D (2007) Role of ERK1/2 signaling pathways in 4-aminopyridine-induced rat pulmonary vasoconstriction. Eur J Pharmacol 569(1-2):138-144 (Pubitemid 47189561)
20. Guo L, Tang X, Tian H, Liu Y, Wang Z, Wu H, Wang J, Guo S, Zhu D (2008) Subacute hypoxia suppresses Kv3.4 channel expression and whole-cell K? currents through endogenous 15-hydroxyeicosatetraenoic acid in pulmonary arterial smooth muscle cells. Eur J Pharmacol 587(1-3):187-195
21. Wang Z, Tang X, Li Y, Leu C, Guo L, Zheng X, Zhu D. (2008) 20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells. Eur J Pharmacol. 24; 588(1):9-17
22. McMurtry MS, Bonnet S, Wu X, Dyck JR, Haromy A, Hashimoto K, Michelakis ED (2004) Dichloroacetate prevents andreverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res 95(8):830-840 (Pubitemid 39390586)
23. Ekhterae D, Platoshyn O, Krick S, Yu Y, McDaniel SS, Yuan JX (2001) Bcl-2 decreases voltage-gated K? channel activity and enhances survival in vascular smooth muscle cells. Am J Physiol Cell Physiol 281(1):C157-C165
24. Tang DG, Chen YQ, Honn KV (1996) Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. Proc Natl Acad Sci USA 93:5241-5246 (Pubitemid 26159433)
25. Hughes FM Jr., Bortner CD, Purdy GD, Cidlowski JA (1997) Intracellular K? suppresses the activation of apoptosis in lymphocytes. J Biol Chem 272:30567-30576 (Pubitemid 27512272)
26. Brevnova EE, Platoshyn O, Zhang S, Yuan JX (2004) Overexpression of human KCNA5 increases IK(V) and enhances apoptosis. Am J Physiol Cell Physiol 287:C715-C722 (Pubitemid 39095858)
27. Zamzami N, Kroemer G (2001) The mitochondrion in apoptosis: how Pandora's box opens. Nat Rev Mol Cell Biol 2(1):67-71 (Pubitemid 33676964)