Sequence selectivity, cross-linking efficiency and cytotoxicity of DNA-targeted 4-anilinoquinoline aniline mustards61

Anti-Cancer Drug Design

Volumn 14, Issue 3, 1999, Pages 187-204

  McClean, Siobhan ^c   Costelloe, Caroline ^a   Denny, William A ^b   Searcey, Mark ^d   Wakelin, Laurence P G ^e  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c ELAN PHARMACEUTICALS   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

4 Anilinoquinoline aniline mustards; Alkylating agent; Cross linking; Cytotoxicity; DNA binding; Minor groove binder; Sequence selectivity

Indexed keywords

ANILINE MUSTARD; CHLORAMBUCIL; MELPHALAN; QUINOLINE DERIVATIVE;

ARTICLE; BINDING SITE; CROSS LINKING; DRUG CYTOTOXICITY; DRUG DNA BINDING; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL;

ALKYLATION; ANILINE MUSTARD; ANTINEOPLASTIC AGENTS, ALKYLATING; ANTIVIRAL AGENTS; BASE SEQUENCE; BINDING SITES; BINDING, COMPETITIVE; CROSS-LINKING REAGENTS; DISTAMYCINS; DNA; HT29 CELLS; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PLASMIDS; QUINOLINES; SUBSTRATE SPECIFICITY;

BRASSICACEAE;

EID: 0032841168     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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