Eliminating bacteria backbone of naked DNA enhanced hFIX expression and reduced inflammatory response in mice

Biomedicine and Pharmacotherapy

Volumn 63, Issue 2, 2009, Pages 129-135

  Zhu, Huan Zhang ^a   Chen, Hong Yan ^a   Feng, Deng Min ^a   Shen, Qi ^a   Xue, Jing Lun ^a   Jia, William ^a,b  

^a FUDAN UNIVERSITY   (China)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cytokines; Gene therapy; Human factor IX; Liver

Indexed keywords

BLOOD CLOTTING FACTOR 9; CIRCULAR DNA; CYTOKINE; INTERLEUKIN 12; LINEAR DNA; LINEAR DNA ELIMINATING BACTERIAL BACKBONE; MESSENGER RNA; NAKED DNA; PLASMID DNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA VECTOR; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE SILENCING; GENE TARGETING; GENE THERAPY; GENETIC TRANSFECTION; HYDRODYNAMICS; HYDRODYNAMICS BASED TRANSFECTION; IN VIVO STUDY; INFLAMMATION; LIVER FUNCTION TEST; LIVER TOXICITY; MALE; MOUSE; NEWBORN; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; TRANSGENE;

ANIMALS; CYTOKINES; DNA; DNA, BACTERIAL; DNA, CIRCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FACTOR IX; GENE EXPRESSION REGULATION; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; MALE; MICE; MICE, INBRED ICR; PLASMIDS; TIME FACTORS; TRANSGENES;

EID: 58949085854     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2008.02.006     Document Type: Article

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