Synthesis and in vitro evaluation of new benzovesamicol analogues as potential imaging probes for the vesicular acetylcholine transporter

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 3, 2005, Pages 745-753

  Zea Ponce, Yolanda ^a   Mavel, Sylvie ^a   Assaad, Thaer ^a   Kruse, Shane E ^b   Parsons, Stanley M ^b   Emond, Patrick ^a   Chalon, Sylvie ^a   Giboureau, Nicolas ^a,c   Kassiou, Michael ^c,d   Guilloteau, Denis ^a  

^a INSERM   (France)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^d University of Sydney   (Australia)

Author keywords

(E) (R,R) 5 AOIBV; (R,R) 5 FPOBV; Benzovesamicol derivatives; VAChT

Indexed keywords

2 HYDROXY 3 (4 PHENYLPIPERIDINO) 5 (3 FLUOROPROPOXY)TETRALIN; 2 HYDROXY 5 (IODOALLYLOXY) 3 (4 PHENYLPIPERIDINO)TETRALIN; 2 HYDROXY 5 IODO 3 (4 AMINOMETHYL 4 PHENYLPIPERIDINO)TETRALIN; 2 HYDROXY 5 IODO 8 METHOXY 3 (4 PHENYLPIPERIDINO)TETRALIN; BENZOVESAMICOL; RADIOLIGAND; TRITIUM; UNCLASSIFIED DRUG; VESAMICOL DERIVATIVE; VESICULAR ACETYLCHOLINE TRANSPORTER;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CHOLINERGIC NERVE; DIAGNOSTIC IMAGING; DRUG BINDING SITE; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; IN VITRO STUDY; LIGAND BINDING; PHARMACODYNAMICS; STRUCTURE ACTIVITY RELATION;

MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE TRANSPORT PROTEINS; MOLECULAR PROBES; PIPERIDINES; STEREOISOMERISM; VESICULAR ACETYLCHOLINE TRANSPORT PROTEINS;

EID: 19944429625     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.10.043     Document Type: Article

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