Cholinergic activity of aged rhesus monkeys revealed by positron emission tomography

Synapse

Volumn 39, Issue 1, 2001, Pages 95-100

  Voytko, Mary Lou ^a   Mach, Robert H ^a   Gage, H Donald ^a   Ehrenkaufer, Richard L E ^a   Efange, Simon M N ^b   Tobin, Joseph R ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Aging; Cholinergic terminals; Functional imaging; Individual differences; Rhesus monkey; Vesicular acetylcholine transporter

Indexed keywords

AGING; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN FUNCTION; CHOLINERGIC ACTIVITY; IMAGE ANALYSIS; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

ACETYLCHOLINE; AGING; ANIMALS; BASAL GANGLIA; CARRIER PROTEINS; CEREBELLUM; FLUORINE RADIOISOTOPES; FLUOROBENZENES; MACACA MULATTA; MALE; MEMBRANE TRANSPORT PROTEINS; NEUROMUSCULAR DEPOLARIZING AGENTS; PIPERIDINES; PRESYNAPTIC TERMINALS; TOMOGRAPHY, EMISSION-COMPUTED; VESICULAR ACETYLCHOLINE TRANSPORT PROTEINS; VESICULAR TRANSPORT PROTEINS;

EID: 0035216288     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2396(20010101)39:1<95::AID-SYN12>3.0.CO;2-2     Document Type: Article

References (56)

1. 3H]Vesamicol binding in brain: Autoradiographic distribution, pharmacology, and effect of cholinergic lesions
2. Pharmacological characterization of the acetylcholine transport system in purified Torpedo electric organ synaptic vesicles
3. 3H]-piperidino)cyclohexanol
4. Neurobiological substrates of behavioral decline: Models and data analytic strategies for individual differences in aging
5. Neurotransmitters in neocortex of aged rhesus monkeys
6. The cholinergic system in aging
7. The neuromuscular blocking action of 2-(4-phenylpiperidino)cyclohexanol (AH 5183)
8. Divergence of biological and chronological aging: Evidence from rodent studies
9. In vivo and in vitro studies on the regulation of cholinergic neurotransmission in striatum, hippocampus, and cortex of aged rats
10. The effects of aging on hippocampal and cortical projections of the forebrain cholinergic system
11. 18F]FBT): Molecular decomposition-reconstitution approach to vesamicol receptor radioligands for positron emission tomography
12. Comparative tissue distribution of conformationally restricted radioiodinated vesamicol receptor ligands
13. Reproducibility of repeated measures of [F18] (+)-4-fluorobenzyltrozamicol binding in the rhesus monkey brain
14. Expression of the putative vesicular acetylcholine transporter in rat brain and localization in cholinergic synaptic vesicles
15. Age-related behavioral and neurochemical deficits: The cholinergic system revisited
16. 2/acetylcholine interactions: PET studies of the vesamicol receptor
17. 11C] dihydrotetrabenazine by dynamic PET: Measurement of vesicular monoamine transporter
18. Regional and subcellular distribution and kinetic properties of rat brain choline acetyltransferase - Some functional considerations
19. In vivo mapping of cholinergic neurons in the human brain using SPECT and IBVM
20. In vivo mapping of cholinergic terminals in normal aging. Alzheimer's disease, and Parkinson's disease
21. Colocalization of acetycholinesterase and choline acetyltransferase in the cerebrum
22. 11C-methyl]-(-)-cocaine PET studies in human subjects
23. 2 receptor-based imaging agents
24. 18F](+)-4-fluorobenzyltrozamicol. In vitro binding studies and positron emission tomography studies in nonhuman primates
25. Quantitative autoradiography of brain binding sites for the vesicular acetylcholine transport blocker 2-(4-phenylpiperidino) cyclohexanol (AH 5183)
26. Studies on the blocking action of 2-(4-phenylpiperidino)cyclohexanol (AH 5183)
27. Biochemical evidence that vesicles are the source of the acetylcholine released from stimulated PC12 cells
28. Central cholinergic functioning and aging
29. Neuronal nicotinic receptors and their implications in aging and neurodegenerative disorders in mammals
30. Acetylcholine transport, storage and release
31. Acetylcholine release from rat cortical slices during postnatal development and aging
32. The brain cholinergic system in aging mammals
33. Neurobiological bases of age-related cognitive decline in the rhesus monkey
34. Characterization and autoradiographic distribution of hemicholinium-3 high-affinity choline uptake sites in mammalian brain
35. Cognitive neuroscience perspectives on aging in nonhuman primates
36. Vesamicol blocks the recovery, by recycling cholinergic electromotor synaptic vesicles, of the biophysical characteristics of the reserve population
37. Molecular cloning of a putative vesicular transporter for acetylcholine
38. Comparing age-related changes in the basal forebrain and hippocampus of the rhesus monkey
39. Changes in enzymes of the cholinergic system and acetylcholine release in the cerebral cortex of aging male Fischer rats
40. A comparison of the distribution of central cholinergic neurons as demonstrated by acetylcholinesterase pharmacohistochemistry and choline acetyltransferase immunohistochemistry
41. Distribution of the vesicular acetylcholine transporter (VAChT) in the central and peripheral nervous system of the rat
42. Human and monkey cholinergic neurons visualized in paraffin-embedded tissues by immunoreactivity for VAChT, the vesicular acetylcholine transporter
43. Regional concentrations of choline and acetylcholine in the rat brain
44. Cholinergic cell loss and hypertrophy in the medial septal nucleus of the behaviorally characterized aged rhesus monkey
45. Survival rate and life span of rhesus monkeys at the Yerkes regional primate research center
46. Evidence that an ATPase and protonmotive force function in the transport of acetylcholine into storage vesicles
47. Age-dependent decrease in the affinity of muscarinic M1 receptors in neocortex of rhesus monkeys
48. Cloning and expression of the vesamicol binding protein from the marine ray Torpedo. Homology with the putative vesicular acetylcholine transporter UNC-17 from Caenorhabditis elegans
49. Cholinergic cell number in the nucleus basalis of young and aged behaviorally characterized monkeys
50. Neuronal number and size are preserved in the nucleus basalis of aged rhesus monkeys
51. Changes in cholinergic receptor subtypes in behaviorally-tested, aged monkeys
52. Laminar organization and age-related loss of cholinergic receptors in temporal neocortex of rhesus monkey
53. Visualization of the vesicular acetylcholine transporter in cholinergic nerve terminals and its targeting to a specific population of small synaptic vesicles
54. Age-related changes in monkey and rodent neurochemistry
55. Age-related changes in multiple neurotransmitter systems in the monkey brain
56. Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys