Synthesis and evaluation of radiolabeled piperazine derivatives of vesamicol as SPECT agents for cholinergic neurons

Nuclear Medicine and Biology

Volumn 28, Issue 3, 2001, Pages 251-260

  Bando, Kazunori ^a,b   Taguchi, Kazumi ^a   Ginoza, Yasushi ^a   Naganuma, Tomoyoshi ^a   Tanaka, Yoshitomo ^a   Koike, Katsuo ^b   Takatoku, Keizo ^a  

^a Daiichi Radioisotope Laboratories Ltd   (Japan)

^b TOHO UNIVERSITY   (Japan)

Author keywords

Autoradiography; Cholinergic; Radioiodinated ligand; Synaptic vesicle; Vesamicol; Vesicular acetylcholine transporter

Indexed keywords

5 IODO 2 HYDROXY 3 [4 (2 METHYLPHENYL)PIPERAZINYL]TETRALIN I 123; METHYL GROUP; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG; VESAMICOL; VESICULAR ACETYLCHOLINE TRANSPORTER;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG SYNTHESIS; GUINEA PIG; IC 50; IMAGING; MALE; NONHUMAN; PARASYMPATHETIC INNERVATION; RADIOACTIVITY; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TISSUE DISTRIBUTION;

ANIMALS; AUTORADIOGRAPHY; BRAIN; CHOLINERGIC FIBERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GUINEA PIGS; MALE; NEUROMUSCULAR DEPOLARIZING AGENTS; NEURONS; PIPERIDINES; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0035040591     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(01)00190-1     Document Type: Article

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