Protection by Nigella sativa against carbon tetrachloride-induced downregulation of hepatic cytochrome P450 isozymes in rats

Japanese Journal of Veterinary Research

Volumn 56, Issue 3, 2008, Pages 119-128

  Ibrahim, Zein S ^a,b   Ishizuka, Mayumi ^a   Soliman, Mohamed ^b   ElBohi, Khlood ^c   Sobhy, Wageh ^a   Muzandu, Kaampwe ^a   Elkattawy, Azza M ^b   Sakamoto, Kentaro Q ^a   Fujita, Shoichi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b Kafrelsheikh University   (Egypt)

^c Zagazig University   (Egypt)

Author keywords

Carbon tetrachloride; Cytochrome P450; Nigella sativa oil

Indexed keywords

CYTOCHROME P450; INTERLEUKIN 10; ISOENZYME; VEGETABLE OIL;

ANIMAL; ARTICLE; BLACK CUMIN; CHEMISTRY; DOWN REGULATION; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; INTOXICATION; LIVER MICROSOME; MALE; METABOLISM; PHYTOTHERAPY; RAT;

ANIMALS; CARBON TETRACHLORIDE POISONING; CYTOCHROME P-450 ENZYME SYSTEM; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INTERLEUKIN-10; ISOENZYMES; MALE; MICROSOMES, LIVER; NIGELLA SATIVA; PHYTOTHERAPY; PLANT OILS; RATS;

NIGELLA SATIVA; RANUNCULACEAE; RATTUS;

EID: 58549120827     PISSN: 00471917     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Ali, B. H. and Blunden, G. 2003. Pharmacological and toxicological properties of Nigella sativa. Phytother. Res., 17: 299-305.
2. Cassatella, M. A., Meda, L., Bonora, S., Ceska, M. and Constantin, G. 1993. Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an automne role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide. J. Exp. Med., 178: 2207-2211.
3. El-Tahir, K. E., Ashour, M. M. and Al-Harbi, M. M. 1993. The respiratory effects of the volatile oil of the black seed (Nigella sativa) in guineapigs: elucidation of the mechanism(s) of action. Gen. Pharmacol., 24:1115-1122.
4. El-Dakhakhny, M. 1965. Studies on the Egyptian Nigella sativa L: IV. Some pharmacological properties of the seeds' active principle in comparison to its dihydro compound and its polymer. Arzneimittelforschung, 15: 1227-1229.
5. Gruebele, A., Zawaski, K., Kaplan, D. and Novak, R. F. 1996. Cytochrome P4502E1-and cytochrome P4502B1/2B2-catalyzed carbon tetrachloride metabolism: effects on signal transduction as demonstrated by altered immediate-early (c-Fos and c-Jun) gene expression and nuclear AP-1 and NF-kappa B transcription factor levels. Drug Metab. Dispos., 24: 15-22.
6. Kara, H., Mitani, N. and Adachi, T. 2000. Inhibitory effect of nitric oxide on the induction of cytochrome P450 3A4mRNA by 1,25-dihydroxyvitamin D3 in Caco-2 cells. Free Radic. Res., 33: 279-285.
7. Houghton, P. J., Zarka, R., DeLas, Heras, B. and Hoult, J. R. 1995. Fixed oil of Nigella sa tiva and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med., 61: 33-36.
8. Iber, H., Sewer, M. B., Barclay, T. B., Mitchell, S. R., Li, T. and Morgan, E. T. 1999. Modulation of drug metabolism in infectious and inflammatory diseases. Drug Metab. Rev., 31: 29-41.
9. Khatsenko, O. and Kikkawa, Y. 1997. Nitric oxide differentially affects constitutive cytochrome P450 isoforms in rat liver. J. Pharmacol. Exp. Ther., 280: 1463-1470.
10. Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterstrom, R. H., Perlmann, T. and Lehmann, J. M. 1998. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell, 92: 73-82.
11. 4-treated rats using in vivo CYP1A2 and CYP3A2 contents assessed with the PKCYP test. Drug Metab. Pharmacokinet., 20: 168-176.
12. Laemmli, U. K. 1970. Cleavage of structural protein during the assembly of the head of bacteriophage T4. Nature, 227: 680-685.
13. Lowry, O. H., Rosebrough, N. J., Fair, A. L. and Randall, R. J. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193: 265-275.
14. Luckey, S. W. and Petersen, D. R. 2001. Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats. Exp. Mol. Pathol., 71: 2226-2240.
15. Manno, M., Ferrara, R., Cazzaro, S., Rigotti, P. and Ancona, E. 1992. Suicidal inactivation of human cytochrome P-450 by carbon tetrachloride and halothane in vitro. Pharmacol. Toxicol., 70: 13-18.
16. Mansour, M. A. 2000. Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice. Life Sci., 66: 2583-2591.
17. Monshouwer, M., McLellan, R. A., Delaporte, E., Witkamp, R. F., van Miert, A. S. and Renton, K. W. 1996. Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome P450. Biochem. Pharmacol., 52: 1195-1200.
18. Morgan, E. T. 1997. Regulation of cytochromes P450 during inflammation and infection. Drug Metab. Rev., 4: 1129-1188.
19. Morgan, E. T. 2001. Regulation of cytochrome p450 by inflammatory mediators: why and how? Drug Metab. Dispos., 29: 207-212.
20. Omura, T. and Sato, R. 1964. The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, Purification, and properties. J. Biol. Chem., 239: 2379-2385.
21. Pascussi, J. M., Gerbal-Chaloin, S., Pichard-Garcia, L., Daujat, M., Fabre, J. M., Maurel, P. and Vilarem, M. J. 2000. Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes. Biochem. Biophys. Res. Commun., 274: 707-713.
22. Ramadan, M. F., Kroh, L. W. and Morsel, J. T. 2003. Radical scavenging activity of black cumin (Nigella sativa L.), coriander (Coriandrum sativum L.), and niger (Guizotia abyssinica Cass.) crude seed oils and oil fractions. J. Agric. Food Chem., 51:6961-6969.
23. Salomi, M. J., Nair, S. C. and Panikkar, K. R. 1991. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nutr. Cancer, 16: 67-72.
24. Takemura, S., Minamiyama, Y., Imaoka, S., Funae, Y., Hirohashi, K., Inoue, M. and Kinoshita, H. 1999. Hepatic cytochrome P450 is directly inactivated by nitric oxide, not by inflammatory cytokines, in the early phase of endotoxemia. J. Hepatol., 3: 1035-1044.
25. Towbin, H., Staehelin, T. and Gordon, J. 1979. Electrophoresis transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc. Natl. Acad. Sci. U.S.A., 76: 4350-4354.
26. Worthen, D. R., Ghosheh, O. A. and Crooks, P. A. 1998. The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L. Anticancer Res., 18: 1527-1533.
27. Wright, K. and Morgan, E. T. 1990. Transcriptional and post-transcriptional suppression of P450IIC11 and P450IIC12 by inflammation. FEBS Lett., 271: 59-61.