Hepatic cytochrome P450 is directly inactivated by nitric oxide, not by inflammatory cytokines, in the early phase of endotoxemia

Journal of Hepatology

Volumn 30, Issue 6, 1999, Pages 1035-1044

  Takemura, Shigekazu ^a   Minamiyama, Yukiko ^a   Imaoka, Susumu ^a   Funae, Yoshihiko ^a   Hirohashi, Kazuhiro ^a   Inoue, Masayasu ^a   Kinoshita, Hiroaki ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cytochrome P450 (P450); Endotoxemia; Nitric oxide (NO)

Indexed keywords

CYTOCHROME P450; CYTOKINE; ICOSANOID; IRON COMPLEX; LIPOPOLYSACCHARIDE; MIDAZOLAM; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; STEROID; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DISEASE COURSE; ELECTRON SPIN RESONANCE; ENDOTOXEMIA; ENZYME INDUCTION; GENE REPRESSION; HYDROXYLATION; LIVER METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SLEEP TIME;

EID: 0032998193     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(99)80257-8     Document Type: Article

References (42)

1. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acethylcholine. Nature. 288:1980;373-376.
2. Moncada S, Higgs EA. Endogenous nitric oxide: physiology, pathology and clinical relevance. Eur J Clin Invest. 21:1991;361-374.
3. Stamler JS, Singel DJ, Loscalzo J. Biochemistry of nitric oxide and its redox-activated forms. Science. 258:1992;1898-1902.
4. Pellet C, Henryn Y, Drapier C. IFN-gamma-activated macrophages: detection by electron paramagnetic resonance of complexes between L-arginine-derived nitric oxide and nonheme iron proteins. Biochem Biophys Res Commun. 166:1990;119-125.
5. Lancaster JR Jr, Hibbs JB Jr. EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages. Proc Natl Acad Sci USA. 87:1990;1223-1227.
6. Renton KW. Factors affecting drug biotransformation. Clin Biochem. 19:1986;72-75.
7. Batra JK, Venkitasubramanian TA, Raj HG. Drug metabolism in experimental tuberculosis. I. Changes in hepatic and pulmonary monooxygenase activities due to infection. Eur J Drug Metab Pharmacol. 12:1987;109-114.
8. Beck FJ, Whitehouse MW. Impaired drug metabolism in rats associated with acute inflammation: a possible assay for anti-injury agents. Proc Soc Exp Biol Med. 145:1974;135-140.
9. Kato R. Drug metabolism under pathological and abnormal physiological states in animals and man. Xenobiotica. 7:1977;25-92.
10. Mahu JL, Feldman G. Study of biochemical behavior of some exported and nonexported hepatic proteins during an acute inflammation reaction in the rat. Enzyme (Basel). 31:1984;234-240.
11. Endo Y, Tsuriya S, Fujihira E. Hepatic drug-metabolizing enzyme activities and anti-inflammatory potency of hydrocortisone in rats with granulomatous inflammation. Res Commun Chem Pathol Pharmacol. 33:1981;195-206.
12. Bear AN, Green FA. Cytochrome P-450 mediated metabolism in active murine systemic lupus erythematosus. J Rheumatol. 16:1989;335-338.
13. Ghezzi P, Saccardo B, Villa P, Rossi V, Bianchi M, Dinarello CA. Role of interleukin-1 in the depression of liver drug metabolism by endotoxin. Infect Immun. 54:1986;837-840.
14. Shedlofsky SI, Swim AT, Robinson JM Gallichio VS, Cohen DA, McClain CJ. Interleukin-1 (IL-1) depresses cytochrome P-450 levels and activities in mice. Life Sci. 40:1987;2331-2336.
15. Khatsenko O, Kikkawa Y. Nitric oxide differentially affects constitutive cytochrome P450 isoforms in rat liver. J Pharmacol Exp Ther. 280:1997;1463-1470.
16. Feelisch M, Noack EA. Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase. Eur J Pharmacol. 139:1987;19-30.
17. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 193:1951;265-275.
18. Wyard SJ, Elliott JP. ESR studies of radiation damage in nucleic acids, bases, nucleosides and nucleotides. Ann NY Acad Sci. 222:1973;628-639.
19. 15N]nitrate in biological fluids. Anal Biochem. 126:1982;131-138.
20. Funae Y, Imaoka S. Simultaneous purification of multiple forms of rat liver microsomal cytochrome P-450 by high-performance liquid chromatography. Biochem Biophys Acta. 842:1985;119-132.
21. Chomczynski P, Sacchi N. Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:1987;156-159.
22. Omura T, Sato R. The carbon monoxide-binding pigment of liver microsomes. 1. Evidence for its hemoprotein nature. J Biol Chem. 239:1964;2370-2378.
23. Phillips AV, Langdom RG. Hepatic triphosphopyridine nucleotide-cytochrome c reductase: isolation, characterization and kinetic studies. J Biol Chem. 237:1962;2652-2660.
24. Imaoka S, Terano Y, Funae Y. Purification and characterization of two constitutive cytochromes P-450 (F-1 and F-2) from adult female rats: identification of P-450F-1 as the phenobarbital-inducible cytochrome P-450 in male rat liver. Biochem Biophys Acta. 916:1987;358-367.
25. Donahue BS, Skottner-Lundin A, Morgan ET. Growth hormone-dependent and -independent regulation of cytochrome P-450 isoform expression in streptozotocin-diabetic rats. Endocrinology. 128:1991;2065-2076.
26. Yoshioka H, Morohashi K, Sogawa K, Miyata T, Kawajiri K, Hirose T, et al. Structural analysis and specific expression of microsomal cytochrome P-450 (M-1) mRNA in male rat livers. J Biol Chem. 262:1987;1706-1711.
27. Miyata M, Nagata K, Shimada M, Yamazoe Y, Kato R. Structure of a gene and cDNA of a major constitutive form of testosterone 6 beta-hydroxylase (P450/6 beta A) encoding CYP3A2: comparison of the cDNA with P450PCN2. Arch Biochem Biophys. 314:1994;351-359.
28. Funae Y, Imaoka S. Purification and characterization of liver microsomal cytochrome P-450 from untreated male rats. Biochem Biophys Acta. 926:1987;349-358.
29. Imaoka S, Kamataki T, Funae Y. Purification and characterization of six cytochromes P-450 from hepatic microsomes of immature female rats. J Biochem. 102:1987;843-851.
30. Kosaka H, Sawai Y, Sakaguchi H, Kumura E, Harada N, Watanabe M, et al. ESR spectral transition by arteriovenous cycle in nitric oxide hemoglobin of cytokine-treated rats. Am J Physiol. 266:1994;C1400-C1405.
31. Stamler JS. Redox signaling: nitrosylation and related target interactions of nitric oxide. Cell. 78:1994;931-936.
32. Morgan ET, Thomas KB, Swanson R, Vales T, Hwang J, Wright K. Selective suppression of cytochrome P-450 gene expression by interleukins 1 and 6 in rat liver. Biochem Biophys Acta. 1219:1994;475-483.
33. Sewer MB, Morgan ET. Nitric oxide-independent supression of P-450 2C11 expression by interleukin-1β and endotoxin in primary rat hepatocytes. Biochem Pharmacol. 54:1997;729-737.
34. Wright K, Morgan ET. Suppression of the constitutive expression of cytochrome P-450 2C11 by cytokines and interferons in primary cultures of rat hepatocytes: comparison with induction of acute-phase genes and demonstration that CYP2C11 promoter sequences are involved in the suppressive response to interleukins 1 and 6. Mol Pharmacol. 39:1991;468-474.
35. Morgan ET. Regulation of cytochrome P450IIC12 expression by interleukin-1 alpha, interleukin-6, and dexamethasone. Biochem Pharmacol. 42:1991;51-57.
36. Craig PI, Mehta I, Murray M, McDonald D, Aström A, van der Meide PH, et al. Interferon down regulates the male-specific cytochrome P450IIIA2 in rat liver. Mol Pharmacol. 38:1990;313-318.
37. Morgan ET, Thomas KB, Swanson R, Vales T, Hwang J, Wright K. Selective suppression of cytochrome P-450 gene expression by interleukins 1 and 6 in rat liver. Biochem Biophys Acta. 1219:1994;475-483.
38. Donato MT, Guillén MI, Jover R, Castell JV, Gómez-Lechón MJ. Nitric oxide-mediated inhibition of cytochrome P450 by interferon-γ in human hepatocytes. J Pharmacol Exp Ther. 281:1997;484-490.
39. Gonzalez F. The molecular biology of the cytochrome P450s. Pharmacol Rev. 40:1989;243-287.
40. Minamiyama Y, Takemura S, Imaoka S, Funae Y, Tanimoto Y, Inoue M. Irreversible inhibition of cytochrome P450 by nitric oxide. J Pharmacol Exp Ther. 283:1998;1479-1485.
41. Nelson D, Kamataki T, Waxman JD, Guengerich FP, Estabrook R, Feyereisen R, et al. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 12:1993;1-51.
42. Kumar G, Walle U, Walle T. Cytochrome P450 3A-mediated human liver microsomal taxol 6α-hydroxylation. J Pharmacol Exp Ther. 268:1994;1160-1165.