Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives

Journal of Medicinal Chemistry

Volumn 50, Issue 23, 2007, Pages 5833-5839

  Kuettel, Sabine ^a   Zambon, Alfonso ^a,b,d   Kaiser, Marcel ^c   Brun, Reto ^c   Scapozza, Leonardo ^a   Perozzo, Remo ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b CA' FOSCARI UNIVERSITY OF VENICE   (Italy)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 ETHYLPHENYL) 3 (TETRAHYDROPYRAN 4 YL)PROPANE 1,3 DIONE; 1 (4 PHENOXYPHENYL) 3 (TETRAHYDROPYRAN 4 YL)PROPANE 1,3 DIONE; 1 [5 (4 PHENOXYPHENYL) 2H PYRAZOL 3 YL]PIPERAZINE; 1,3 DIKETONE; 4 [2 (4 NITROPHENYL) 5 (4 PHENOXYPHENYL) 2H PYRAZOL 3 YL]MORPHOLINE; 4 [5 (4 PHENOXYPHENYL) 2H PYRAZOL 3 YL]MORPHOLINE; 4 [5 (4 PHENOXYPHENYL) 2H PYRAZOL 3 YL]MORPHOLINE DERIVATIVE; 4 [5 (4 PHENOXYPHENYL) 2H PYRAZOL 3 YL]PIPERAZINE 1 CARBOXYLIC ACID TERT BUTYL ESTER; 4 MORPHOLIN 4 YL 1 (4 PHENOXYPHENYL)BUTANE 1,3 DIONE; MORPHOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; EVALUATION; IC 50; INFRARED SPECTROSCOPY; LEISHMANIA DONOVANI; NONHUMAN; PLASMODIUM FALCIPARUM; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; TRYPANOSOMA RHODESIENSE;

ANIMALS; ANTIMALARIALS; LEISHMANIA DONOVANI; MORPHOLINES; PLASMODIUM FALCIPARUM; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA;

EID: 36148964016     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm700938n     Document Type: Article

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