Metabolism and renal elimination of gaboxadol in humans: Role of UDP-glucuronosyltransferases and transporters

Pharmaceutical Research

Volumn 26, Issue 2, 2009, Pages 459-468

  Chu, Xiao Yan ^a   Liang, Yuexia ^a   Cai, Xiaoxin ^a   Cuevas Licea, Karla ^a   Rippley, Ronda K ^a   Kassahun, Kelem ^a   Shou, Magang ^a,b   Braun, Matthew P ^a   Doss, George A ^a   Anari, M Reza ^a,c   Evers, Raymond ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b AMGEN INC   (United States)

^c ADOLOR CORPORATION   (United States)

Author keywords

Gaboxadol; Glucuronidation; Kidney; Transporters

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CARBON 14; DRUG METABOLITE; GABOXADOL; GABOXADOL O GLUCURONIDE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 4; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; ORGANIC CATION TRANSPORTER 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CHO K1 CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ELIMINATION; DRUG GLUCURONIDATION; DRUG LABELING; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSPORT; DRUG UPTAKE; DRUG URINE LEVEL; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INSECT CELL; KIDNEY MICROSOME; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MEMBRANE VESICLE; MICHAELIS MENTEN KINETICS; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ADMINISTRATION, ORAL; ANIMALS; BIOTRANSFORMATION; CHO CELLS; CHROMATOGRAPHY, LIQUID; CRICETINAE; CRICETULUS; GABA AGONISTS; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; ISOENZYMES; ISOXAZOLES; KIDNEY; LIVER; MEMBRANE TRANSPORT PROTEINS; MICROSOMES, LIVER; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ORGANIC ANION TRANSPORT PROTEIN 1; RECOMBINANT PROTEINS; TANDEM MASS SPECTROMETRY; TRANSFECTION;

EID: 58549093350     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9799-5     Document Type: Article

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