Spiro-piperidine azetidinones as potent TRPV1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 3, 2009, Pages 783-787

  Xiao, Dong ^a   Palani, Anandan ^a   Aslanian, Robert ^a   McKittrick, Brian A ^a   McPhail, Andrew T ^b   Correll, Craig C ^a   Phelps, P Tara ^a   Anthes, John C ^a   Rindgen, Diane ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

Spiro azetidinone stability; TRPV1

Indexed keywords

AZETIDINE DERIVATIVE; PIPERIDINE DERIVATIVE; SPIRO COMPOUND; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST;

AREA UNDER THE CURVE; ARTICLE; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IC 50; NONHUMAN; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; AZETIDINES; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HYDROGEN-ION CONCENTRATION; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; RATS; SPIRO COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRPV CATION CHANNELS;

RATTUS;

EID: 58549085376     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.12.024     Document Type: Article

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