An approach to the synthesis of 5,5-trans-fused lactam analogues of β-lactam antibiotics

Journal of the Chemical Society. Perkin Transactions 1

Volumn , Issue 1, 2001, Pages 21-25

  Smith, Paul W ^a   Whittington, Andrew R ^a   Cobley, Kevin N ^a   Jaxa Chamiec, Albert ^a   Finch, Harry ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATOGRAPHY; CRYSTALLINE MATERIALS; CRYSTALLIZATION; ENZYMES; ESTERS; ISOMERS; SALTS; STEREOCHEMISTRY; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

ANTIBACTERIAL AGENTS;

ANTIBIOTICS;

EID: 0035819444     PISSN: 14727781     EISSN: None     Source Type: Journal    
DOI: 10.1039/b007286i     Document Type: Article

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27. 3 (cfu = colony forming units). The plates were incubated at 37 °C for 18 hours and the minimum inhibitory concentration (MIC) value interpreted as the lowest antibiotic concentration which completely inhibited bacterial growth.
28. -3) was added. The enzymatic hydrolysis of nitrocefin was followed at 495 nm. Compound 6 failed to inhibit the activity of TEM-1 at the highest concentration used (1 mM).