Synthesis and evaluation of thiazole carboxamides as vanilloid receptor 1 (TRPV1) antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 23, 2005, Pages 5211-5217

  Xi, Ning ^a   Bo, Yunxin ^a   Doherty, Elizabeth M ^a   Fotsch, Christopher ^a   Gavva, Narender R ^a   Han, Nianhe ^a   Hungate, Randall W ^a   Klionsky, Lana ^a   Liu, Qingyian ^a   Tamir, Rami ^a   Xu, Shimin ^a   Treanor, James J S ^a   Norman, Mark H ^a  

^a AMGEN INC   (United States)

Author keywords

Antagonists; Thiazole carboxamides; Vanilloid receptor 1 (TRPV1)

Indexed keywords

2 (2,6 DICHLOROBENZYL) N (4 ISOPROPYLPHENYL)THIAZOLE 4 CARBOXAMIDE; 4 METHYL 5 CARBOXAMIDE; ACID; AMIDE; CALCIUM; CAPSAICIN; IMIDAZOLE; OXAZOLE; PYRIDINE DERIVATIVE; RECEPTOR BLOCKING AGENT; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ANIMAL CELL; ARTICLE; ASSAY; CALCIUM TRANSPORT; CHO CELL; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IC 50; NONHUMAN; PROTEIN EXPRESSION; RAT;

AMIDES; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; MOLECULAR STRUCTURE; OXAMIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TRPV CATION CHANNELS;

EID: 26844506569     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.08.100     Document Type: Article

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