메뉴 건너뛰기




Volumn 25, Issue 1, 2009, Pages 59-65

Aberrant crypt foci: Are they intermediate endpoints of colon carcinogenesis in humans?

Author keywords

Aberrant crypt foci; Biomarker; Colorectal cancer; High magnification colonoscopy

Indexed keywords

BIOLOGICAL MARKER;

EID: 58349100295     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e32831db286     Document Type: Review
Times cited : (33)

References (53)
  • 2
    • 0023629080 scopus 로고
    • Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: Preliminary findings
    • Bird RP. Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett 1987; 37:147-151.
    • (1987) Cancer Lett , vol.37 , pp. 147-151
    • Bird, R.P.1
  • 4
    • 0036441901 scopus 로고    scopus 로고
    • Most effective colon cancer chemopreventive agents in rats: A systematic review of aberrant crypt foci and tumor data, ranked by potency
    • Corpet DE, Tache S. Most effective colon cancer chemopreventive agents in rats: a systematic review of aberrant crypt foci and tumor data, ranked by potency. Nutr Cancer 2002; 43:1-21.
    • (2002) Nutr Cancer , vol.43 , pp. 1-21
    • Corpet, D.E.1    Tache, S.2
  • 5
    • 0025753555 scopus 로고
    • Aberrant crypts: Putative preneoplastic foci in human colonic mucosa
    • Pretlow TP, Barrow BJ, Ashton WS, et al. Aberrant crypts: putative preneoplastic foci in human colonic mucosa. Cancer Res 1991; 51:1564-1567.
    • (1991) Cancer Res , vol.51 , pp. 1564-1567
    • Pretlow, T.P.1    Barrow, B.J.2    Ashton, W.S.3
  • 6
    • 0030885138 scopus 로고    scopus 로고
    • Detection of aberrant crypt foci by magnifying colonoscopy
    • Yokota T, Sugano K, Hondo H, et al. Detection of aberrant crypt foci by magnifying colonoscopy. Gastrointest Endosc 1997; 46:61-65.
    • (1997) Gastrointest Endosc , vol.46 , pp. 61-65
    • Yokota, T.1    Sugano, K.2    Hondo, H.3
  • 7
    • 33744800861 scopus 로고    scopus 로고
    • Assessment of rectal aberrant crypt foci by standard chromoscopy and its predictive value for colonic advanced neoplasms
    • Seike K, Koda K, Oda K, et al. Assessment of rectal aberrant crypt foci by standard chromoscopy and its predictive value for colonic advanced neoplasms. Am J Gastroenterol 2006; 101:1362-1369.
    • (2006) Am J Gastroenterol , vol.101 , pp. 1362-1369
    • Seike, K.1    Koda, K.2    Oda, K.3
  • 8
    • 57249089705 scopus 로고    scopus 로고
    • Cho NL, Redston M, Zauber AG, et al. Aberrant Crypt Foci in the Adenoma •• Prevention with Celecoxib Trial. Cancer Prev Res 2008; 1:OF1-OF11. This is a human study that employs ACF as an intermediate endpoint, nested within an adenoma prevention trial that uses celecoxib.
    • Cho NL, Redston M, Zauber AG, et al. Aberrant Crypt Foci in the Adenoma •• Prevention with Celecoxib Trial. Cancer Prev Res 2008; 1:OF1-OF11. This is a human study that employs ACF as an intermediate endpoint, nested within an adenoma prevention trial that uses celecoxib.
  • 9
    • 57249113909 scopus 로고    scopus 로고
    • Sporadic aberrant crypt foci are not a surrogate endpoint for colorectal adenoma prevention
    • Lance P, Hamilton SR. Sporadic aberrant crypt foci are not a surrogate endpoint for colorectal adenoma prevention. Cancer Prev Res 2008; 1:OF2 - OF5.
    • (2008) Cancer Prev Res , vol.1
    • Lance, P.1    Hamilton, S.R.2
  • 10
    • 58349112697 scopus 로고    scopus 로고
    • Prevalence and Risk Factors for Aberrant Crypt Foci: An ancillary study to the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial
    • Mutch M, Schoen RE, Fleshman JW, et al. Prevalence and Risk Factors for Aberrant Crypt Foci: an ancillary study to the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Gastroenterology 2008; 132:20.
    • (2008) Gastroenterology , vol.132 , pp. 20
    • Mutch, M.1    Schoen, R.E.2    Fleshman, J.W.3
  • 11
    • 44149102048 scopus 로고    scopus 로고
    • Schoen RE, Mutch M, Rall C, et al. The natural history of aberrant crypt foci. •• Gastrointest Endosc 2008; 67:1097-1102. The first study on the natural history of ACF, showing that only 43% of ACF can be reidentified 1 year later.
    • Schoen RE, Mutch M, Rall C, et al. The natural history of aberrant crypt foci. •• Gastrointest Endosc 2008; 67:1097-1102. The first study on the natural history of ACF, showing that only 43% of ACF can be reidentified 1 year later.
  • 12
    • 58349097859 scopus 로고    scopus 로고
    • Performance of high magnification colonoscopy (HMC) in detecting aberrant crypt foci (ACF)
    • Gupta AK, Pinsky P, Rall C, et al. Performance of high magnification colonoscopy (HMC) in detecting aberrant crypt foci (ACF). Gastroenterology 2008; 134:A445-A446.
    • (2008) Gastroenterology , vol.134
    • Gupta, A.K.1    Pinsky, P.2    Rall, C.3
  • 13
    • 17144464406 scopus 로고    scopus 로고
    • Aberrant crypt foci of the colon as precursors of adenoma and cancer
    • Takayama T, Katsuki S, Takahashi Y, et al. Aberrant crypt foci of the colon as precursors of adenoma and cancer. N Engl J Med 1998; 339:1277-1284.
    • (1998) N Engl J Med , vol.339 , pp. 1277-1284
    • Takayama, T.1    Katsuki, S.2    Takahashi, Y.3
  • 14
    • 16844381852 scopus 로고    scopus 로고
    • Risk factors for colorectal cancer in relation to number and size of aberrant crypt foci in humans
    • Rudolph RE, Dominttz JA, Lampe JW, et al. Risk factors for colorectal cancer in relation to number and size of aberrant crypt foci in humans. Cancer Epidemiol Biomarkers Prev 2005; 14:605-608.
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 605-608
    • Rudolph, R.E.1    Dominttz, J.A.2    Lampe, J.W.3
  • 15
    • 21344470662 scopus 로고    scopus 로고
    • Rectal aberrant crypt foci identified using high-magnification-chromoscopic colonoscopy: Biomarkers for flat and depressed neoplasia
    • Hurlstone DP, Karajeh M, Sanders DS, et al. Rectal aberrant crypt foci identified using high-magnification-chromoscopic colonoscopy: biomarkers for flat and depressed neoplasia. Am J Gastroenterol 2005; 100:1283-1289.
    • (2005) Am J Gastroenterol , vol.100 , pp. 1283-1289
    • Hurlstone, D.P.1    Karajeh, M.2    Sanders, D.S.3
  • 16
    • 0036834672 scopus 로고    scopus 로고
    • Endoscopic identification and quantification of aberrant crypt foci in the human colon
    • Adler DG, Gostout CJ, Sorbi D, et al. Endoscopic identification and quantification of aberrant crypt foci in the human colon. Gastrointest Endosc 2002; 56:657-662.
    • (2002) Gastrointest Endosc , vol.56 , pp. 657-662
    • Adler, D.G.1    Gostout, C.J.2    Sorbi, D.3
  • 17
    • 52649167893 scopus 로고    scopus 로고
    • Aberrant crypt focus size predicts distal polyp • histopathology
    • A large scale study on ACF prevalence, in which, for the first time, the entire left colon was examined for ACF in all study participants
    • Kim J, Ng J, Arozulllah A, et al. Aberrant crypt focus size predicts distal polyp • histopathology. Cancer Epidemiol Biomarkers Prev 2008; 17:1155-1162. A large scale study on ACF prevalence, in which, for the first time, the entire left colon was examined for ACF in all study participants.
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 1155-1162
    • Kim, J.1    Ng, J.2    Arozulllah, A.3
  • 18
    • 0027264522 scopus 로고
    • Cell kinetic evaluation of human colonic aberrant crypts. (Colorectal Cancer Study group of the University of Modena and the Healthcare District 16, Modena, Italy)
    • Roncucci L, Pedroni M, Fante R, et al. Cell kinetic evaluation of human colonic aberrant crypts. (Colorectal Cancer Study group of the University of Modena and the Healthcare District 16, Modena, Italy). Cancer Res 1993; 53:3726-3729.
    • (1993) Cancer Res , vol.53 , pp. 3726-3729
    • Roncucci, L.1    Pedroni, M.2    Fante, R.3
  • 19
    • 0031944450 scopus 로고    scopus 로고
    • Aberrant crypt foci in human colons: Distribution and histomorphologic characteristics
    • Shpitz B, Bomstein Y, Mekori Y, et al. Aberrant crypt foci in human colons: distribution and histomorphologic characteristics. Hum Pathol 1998; 29:469-475.
    • (1998) Hum Pathol , vol.29 , pp. 469-475
    • Shpitz, B.1    Bomstein, Y.2    Mekori, Y.3
  • 20
    • 0026026294 scopus 로고
    • Identification and quantification of aberrant crypt foci and microadenomas in the human colon
    • Roncucci L, Stamp D, Medline A, et al. Identification and quantification of aberrant crypt foci and microadenomas in the human colon. Hum Pathol 1991;22:287-294.
    • (1991) Hum Pathol , vol.22 , pp. 287-294
    • Roncucci, L.1    Stamp, D.2    Medline, A.3
  • 22
    • 0030982833 scopus 로고    scopus 로고
    • Identification of dysplasia in human colonic aberrant crypt foci
    • Siu IM, Pretlow TG, Amini SB, Pretlow TP. Identification of dysplasia in human colonic aberrant crypt foci. Am J Pathol 1997; 150:1805-1813.
    • (1997) Am J Pathol , vol.150 , pp. 1805-1813
    • Siu, I.M.1    Pretlow, T.G.2    Amini, S.B.3    Pretlow, T.P.4
  • 23
    • 0032927484 scopus 로고    scopus 로고
    • Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease
    • Bouzourene H, Chaubert P, Seetentag W. et al. Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease. Hum Pathol 1999; 30:66-71.
    • (1999) Hum Pathol , vol.30 , pp. 66-71
    • Bouzourene, H.1    Chaubert, P.2    Seetentag, W.3
  • 24
    • 0027138093 scopus 로고
    • K-ras mutations in putative preneoplastic lesions in human colon
    • Pretlow TP, Brasitus TA, Fulton NC, et al. K-ras mutations in putative preneoplastic lesions in human colon. J Natl Cancer Inst 1993; 85:2004-2007.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 2004-2007
    • Pretlow, T.P.1    Brasitus, T.A.2    Fulton, N.C.3
  • 25
    • 0028062973 scopus 로고
    • Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons
    • Smith AJ, Stem HS, Penner M, et al. Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons. Cancer Res 1994; 54:5527-5530.
    • (1994) Cancer Res , vol.54 , pp. 5527-5530
    • Smith, A.J.1    Stem, H.S.2    Penner, M.3
  • 26
    • 0028897398 scopus 로고
    • Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon
    • Yamashita N, Minamoto T, Ochiai A, et al. Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon. Gastroenterology 1995; 108:434-440.
    • (1995) Gastroenterology , vol.108 , pp. 434-440
    • Yamashita, N.1    Minamoto, T.2    Ochiai, A.3
  • 27
    • 0031468110 scopus 로고    scopus 로고
    • Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa
    • Nucci MR, Robinson CR, Longo P, et al. Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa. Hum Pathol 1997; 28:1396-1407.
    • (1997) Hum Pathol , vol.28 , pp. 1396-1407
    • Nucci, M.R.1    Robinson, C.R.2    Longo, P.3
  • 28
    • 0032168852 scopus 로고    scopus 로고
    • Infrequent somatic mutation of the adenomatous polyposis coli gene in aberrant crypt foci of human colon tissue
    • Otori K, Konishi M, Sugiyama K, et al. Infrequent somatic mutation of the adenomatous polyposis coli gene in aberrant crypt foci of human colon tissue. Cancer 1998; 83:896-900.
    • (1998) Cancer , vol.83 , pp. 896-900
    • Otori, K.1    Konishi, M.2    Sugiyama, K.3
  • 29
    • 0034830884 scopus 로고    scopus 로고
    • Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis
    • Takayama T, Ohi M, Hayashi T, et al. Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis. Gastroenterology 2001; 121:599-611.
    • (2001) Gastroenterology , vol.121 , pp. 599-611
    • Takayama, T.1    Ohi, M.2    Hayashi, T.3
  • 30
    • 0027973077 scopus 로고
    • Molecular determinants of dysplasia in colorectal lesions
    • Jen J, Powell SM, Papadopoulos N, et al. Molecular determinants of dysplasia in colorectal lesions. Cancer Res 1994; 54:5523-5526.
    • (1994) Cancer Res , vol.54 , pp. 5523-5526
    • Jen, J.1    Powell, S.M.2    Papadopoulos, N.3
  • 31
    • 34248592612 scopus 로고    scopus 로고
    • Mutations in BRAF and KRAS differentially distinguish serrated versus nonserrated hyperplastic aberrant crypt foci in humans
    • Rosenberg DW, Yang S, Pleau DC, et al. Mutations in BRAF and KRAS differentially distinguish serrated versus nonserrated hyperplastic aberrant crypt foci in humans. Cancer Res 2007; 67:3551-3554.
    • (2007) Cancer Res , vol.67 , pp. 3551-3554
    • Rosenberg, D.W.1    Yang, S.2    Pleau, D.C.3
  • 32
    • 0032894001 scopus 로고    scopus 로고
    • The identification of monoclonality in human aberrant crypt foci
    • Siu IM, Robinson DR, Schwartz S, et al. The identification of monoclonality in human aberrant crypt foci. Cancer Res 1999; 59:63-66.
    • (1999) Cancer Res , vol.59 , pp. 63-66
    • Siu, I.M.1    Robinson, D.R.2    Schwartz, S.3
  • 33
    • 20244383984 scopus 로고    scopus 로고
    • BRAF mutations in aberrant crypt foci and hyperplastic polyposis
    • Beach R, Chan AO, Wu TT, et al. BRAF mutations in aberrant crypt foci and hyperplastic polyposis. Am J Pathol 2005; 166:1069-1075.
    • (2005) Am J Pathol , vol.166 , pp. 1069-1075
    • Beach, R.1    Chan, A.O.2    Wu, T.T.3
  • 34
    • 0029089259 scopus 로고
    • Hereditary nonpolyposis colorectal cancer: The syndrome, the genes, and historical perspectives
    • Marra G, Bdand CR. Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. J Natl Cancer Inst 1995; 87:1114-1125.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1114-1125
    • Marra, G.1    Bdand, C.R.2
  • 35
    • 0029917009 scopus 로고    scopus 로고
    • Evidence for genomic instability in human colonic aberrant crypt foci
    • Augenlicht LH, Richards C, Corner G, Pretlow TP. Evidence for genomic instability in human colonic aberrant crypt foci. Oncogene 1996; 12:1767-1772.
    • (1996) Oncogene , vol.12 , pp. 1767-1772
    • Augenlicht, L.H.1    Richards, C.2    Corner, G.3    Pretlow, T.P.4
  • 36
    • 0030466920 scopus 로고    scopus 로고
    • Microsatellite instability in aberrant crypt foci from human colons
    • Heinen CD, Shivapurkar N, Tang Z, et al. Microsatellite instability in aberrant crypt foci from human colons. Cancer Res 1996; 56:5339-5341.
    • (1996) Cancer Res , vol.56 , pp. 5339-5341
    • Heinen, C.D.1    Shivapurkar, N.2    Tang, Z.3
  • 38
    • 0141954047 scopus 로고    scopus 로고
    • DNA alterations in human aberrant crypt foci and colon cancers by random primed polymerase chain reaction
    • Luo L, Li B, Pretlow TP. DNA alterations in human aberrant crypt foci and colon cancers by random primed polymerase chain reaction. Cancer Res 2003;63:6166-6169.
    • (2003) Cancer Res , vol.63 , pp. 6166-6169
    • Luo, L.1    Li, B.2    Pretlow, T.P.3
  • 39
    • 0035890420 scopus 로고    scopus 로고
    • Beta-catenin expression is altered in human colonic aberrant crypt foci
    • Hao XP, Pretlow TG, Rao JS, Pretlow TP. Beta-catenin expression is altered in human colonic aberrant crypt foci. Cancer Res 2001; 61:8085-8088.
    • (2001) Cancer Res , vol.61 , pp. 8085-8088
    • Hao, X.P.1    Pretlow, T.G.2    Rao, J.S.3    Pretlow, T.P.4
  • 40
    • 33746724690 scopus 로고    scopus 로고
    • Subcellular localization of beta-catenin and APC proteins in colorectal preneoplastic and neoplastic lesions
    • Sena P, Saviano M, Monni S, et al. Subcellular localization of beta-catenin and APC proteins in colorectal preneoplastic and neoplastic lesions. Cancer Lett 2006;241:203-212.
    • (2006) Cancer Lett , vol.241 , pp. 203-212
    • Sena, P.1    Saviano, M.2    Monni, S.3
  • 41
    • 0036098559 scopus 로고    scopus 로고
    • CpG island methylation in aberrant crypt foci of the colorectum
    • Chan AO, Broaddus RR, Houlihan PS, et al. CpG island methylation in aberrant crypt foci of the colorectum. Am J Pathol 2002; 160:1823-1830.
    • (2002) Am J Pathol , vol.160 , pp. 1823-1830
    • Chan, A.O.1    Broaddus, R.R.2    Houlihan, P.S.3
  • 42
    • 20144372468 scopus 로고    scopus 로고
    • CpG island methylation in aberrant crypt foci and cancers from the same patients
    • Luo L, Chen WD, Pretlow TP. CpG island methylation in aberrant crypt foci and cancers from the same patients, Int J Cancer 2005; 115:747-751.
    • (2005) Int J Cancer , vol.115 , pp. 747-751
    • Luo, L.1    Chen, W.D.2    Pretlow, T.P.3
  • 43
    • 0038153876 scopus 로고    scopus 로고
    • SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers
    • Li H, Myeroff L, Smiraglia D, et al. SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. Proc Natl Acad Sci U S A 2003; 100:8412-8417.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8412-8417
    • Li, H.1    Myeroff, L.2    Smiraglia, D.3
  • 44
    • 33745632617 scopus 로고    scopus 로고
    • Epigenetic alterations in RASSF1A in human aberrant crypt foci
    • Greenspan EJ, Jablonski MA, Rajan TV, et al. Epigenetic alterations in RASSF1A in human aberrant crypt foci. Carcinogenesis 2006; 27:1316-1322.
    • (2006) Carcinogenesis , vol.27 , pp. 1316-1322
    • Greenspan, E.J.1    Jablonski, M.A.2    Rajan, T.V.3
  • 45
    • 0033587747 scopus 로고    scopus 로고
    • CpG island methylator phenotype in colorectal cancer
    • Toyota M, Ahuja N, One-Toyota M, et al. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A 1999; 96:8681-8686.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 8681-8686
    • Toyota, M.1    Ahuja, N.2    One-Toyota, M.3
  • 46
    • 17644367518 scopus 로고    scopus 로고
    • Relationship of aging and tobacco use with the development of aberrant crypt foci in a predominantly African-American population
    • Moxon D, Raza M, Kenney R, et al. Relationship of aging and tobacco use with the development of aberrant crypt foci in a predominantly African-American population. Clin Gastroenterol Hepatol 2005; 3:271-278.
    • (2005) Clin Gastroenterol Hepatol , vol.3 , pp. 271-278
    • Moxon, D.1    Raza, M.2    Kenney, R.3
  • 47
    • 40749143178 scopus 로고    scopus 로고
    • Aberrant crypt foci as precursors of the dysplasia-carcinoma sequence in patients with ulcerative colitis
    • Kukitsu T, Takayama T, Miyanishi K, et al. Aberrant crypt foci as precursors of the dysplasia-carcinoma sequence in patients with ulcerative colitis. Clin Cancer Res 2008; 14:48-54.
    • (2008) Clin Cancer Res , vol.14 , pp. 48-54
    • Kukitsu, T.1    Takayama, T.2    Miyanishi, K.3
  • 48
    • 33847400448 scopus 로고    scopus 로고
    • Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer
    • Stevens RG, Swede H, Heinen CD, et al. Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer. Cancer Lett 2007; 248:262-268.
    • (2007) Cancer Lett , vol.248 , pp. 262-268
    • Stevens, R.G.1    Swede, H.2    Heinen, C.D.3
  • 49
    • 0242361159 scopus 로고    scopus 로고
    • Suppressive effect of aspirin on aberrant crypt foci in patients with colorectal cancer
    • Shpitz B, Klein E, Buklan G, et al. Suppressive effect of aspirin on aberrant crypt foci in patients with colorectal cancer. Gut 2003; 52:1598-1601.
    • (2003) Gut , vol.52 , pp. 1598-1601
    • Shpitz, B.1    Klein, E.2    Buklan, G.3
  • 50
    • 33845608798 scopus 로고    scopus 로고
    • Classification of colorectal cancer based on correlation of clinical, morphological and molecular features
    • Jass JR. Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology 2007; 50:113-130.
    • (2007) Histopathology , vol.50 , pp. 113-130
    • Jass, J.R.1
  • 51
    • 58349116592 scopus 로고    scopus 로고
    • Comment re: 'Sporadic Aberrant Crypt Foci Are Not a Surrogate Endpoint for Colorectal Adenoma Prevention' and 'Aberrant Crypt Foci in the Adenoma Prevention with Celecoxib Trial'
    • Stevens RG, Pretlow TP, Hurlstone DP, et al. Comment re: 'Sporadic Aberrant Crypt Foci Are Not a Surrogate Endpoint for Colorectal Adenoma Prevention' and 'Aberrant Crypt Foci in the Adenoma Prevention with Celecoxib Trial'. Cancer Prev Res 2008; 1:215-216.
    • (2008) Cancer Prev Res , vol.1 , pp. 215-216
    • Stevens, R.G.1    Pretlow, T.P.2    Hurlstone, D.P.3
  • 52
    • 58349107214 scopus 로고    scopus 로고
    • Comment re: 'Sporadic Aberrant Crypt Foci Are Not a Surrogate Endpoint for Colorectal Adenoma Prevention' and 'Aberrant Crypt Foci in the Adenoma Prevention with Celecoxib Trial'
    • Zauber AG, Bertagnolli MM. Comment re: 'Sporadic Aberrant Crypt Foci Are Not a Surrogate Endpoint for Colorectal Adenoma Prevention' and 'Aberrant Crypt Foci in the Adenoma Prevention with Celecoxib Trial'. Cancer Prev Res 2008; 1:216.
    • (2008) Cancer Prev Res , vol.1 , pp. 216
    • Zauber, A.G.1    Bertagnolli, M.M.2
  • 53
    • 12144291274 scopus 로고    scopus 로고
    • Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
    • Suzuki H, Watkins DN, Jair KW, et al. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 2004; 36:417-422.
    • (2004) Nat Genet , vol.36 , pp. 417-422
    • Suzuki, H.1    Watkins, D.N.2    Jair, K.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.