Subcellular localization of β-catenin and APC proteins in colorectal preneoplastic and neoplastic lesions

Cancer Letters

Volumn 241, Issue 2, 2006, Pages 203-212

  Sena, Paola ^a   Saviano, Massimo ^a   Monni, Sebastiano ^a   Losi, Lorena ^a   Roncucci, Luca ^a   Marzona, Laura ^a   Pol, Anto De ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Catenin; Aberrant crypt foci; APC; Colorectal carcinoma; Electron microscopy; Familial adenomatous polyposis; Immunogold ultrastructural subcellular distribution

Indexed keywords

APC PROTEIN; BETA CATENIN; WNT PROTEIN;

ACCURACY; ADENOMATOUS POLYP; ARTICLE; CARCINOGENESIS; CELL MEMBRANE; CELLULAR DISTRIBUTION; COLON MUCOSA; COLORECTAL TUMOR; CYTOPLASM; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGOLD ELECTRON MICROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE;

ADENOMATOUS POLYPOSIS COLI; ADENOMATOUS POLYPOSIS COLI PROTEIN; BETA CATENIN; CELL NUCLEUS; COLORECTAL NEOPLASMS; CYTOPLASM; HUMANS; INTESTINAL MUCOSA; MICROSCOPY, IMMUNOELECTRON; PRECANCEROUS CONDITIONS; SUBCELLULAR FRACTIONS;

EID: 33746724690     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.10.011     Document Type: Article

References (30)

1. Jankowski J., and Wright N. Epithelial stem cells in gastrointestinal morphogenesis, adaptation and carcinogenesis. Semin. Cell Biol. 3 (1992) 445-456
2. Morin P.J., Sparks A.B., Korinek V., Barker N., Clevers H., Vogelstein B., and Kinzler K.W. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275 (1997) 1787-1790
3. Mann B., Gelos M., Siedow A., Hanski M.L., Gratchev A., Ilyas M., et al. Target genes of β-caténin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc. Natl Acad. Sci. USA 96 (1999) 1603-1608
4. Gavert N., Conacci-Sorrell M., Gast D., Schneider A., Algevogt P., Blabletz T., and Ben-Ze'ev A. L1, a novel target of β-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. J. Cell Biol. 168 (2005) 633-642
5. Fearon E.R., and Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 61 (1990) 759-767
6. Smith A.J., Stern H.S., Penner M., Hay K., Mitri A., Bapat B.V., and Gallinger S. Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons. Cancer Res. 54 (1994) 5527-5530
7. Jen J., Powell S.M., Papadopoulos N., Smith K.J., Hamilton S.R., Vogelstein B., and Kinzler K.W. Molecular determinants of dysplasia in colorectal lesions. Cancer Res. 54 (1994) 5523-5526
8. Korinek V., Barker N., Morin P.J., van Wirchen D., de Weger R., Kinzler K.W., et al. Constitutive transcriptions activation of a β-catenin-Tcf complex in APC-/- colon carcinoma. Science 275 (1997) 1784-1787
9. Hao X., Tomlinson I., Ilyas M., Palazzo J.P., and Talbot I.C. Reciprocity between membranous and nuclear expression of β-catenin in colorectal tumors. Virchows Arch. 431 (1997) 167-172
10. Takayama T., Ohi M., Hayashi T., Miyanishi K., Nobuoka A., Nakajima T., et al. Analysis of K-ras, APC, and β-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis. Gastroenterology 121 (2001) 599-611
11. Anderson C.B., Neufeld K.L., and White R.L. Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. Proc. Natl Acad. Sci. USA 99 (2002) 8683-8688
12. Hao X., Frayling I.M., Willcocks T.C., Han W., Tomlinson I.P.M., Pignatelli M.N., et al. β-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis. Virchows Arch. 440 (2002) 362-366
13. Roncucci L., Medline A., and Bruce W.R. Classification of aberrant crypt foci and microadenomas in human colon. Cancer Epidemiol. Biomarkers Prev. 1 (1991) 57-60
14. Levine D.S., and Haggitt R.C. Normal histology of the colon. Am. J. Surg. Pathol. 13 (1989) 966-984
15. Munemitsu S., Souza B., Muller O., Albert I., Rubinfeld B., and Polakis P. The APC gene product associates with microtubules in vivo and promotes assembly in vitro. Cancer Res. 54 (1994) 3676-3681
16. Nathke I.S., Adams C.L., Polakis P., Sellin J.H., and Nelson W.J. The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J. Cell Biol. 134 (1996) 165-179
17. Oshima M., Oshima H., Kitagawa K., Kobayashi M., Itakura C., and Taketo M. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc. Natl Acad. Sci. USA 92 (1995) 4482-4486
18. Iwamoto M., Ahnen D.J., Franklin W.A., and Maltzman T.H. Expression of β-catenin and full-length APC protein in normal and neoplastic colonic tissues. Carcinogenesis (London) 21 (2000) 1935-1940
19. Siu I.-M., Robinson D.R., Schwartz S., Kung H.-J., Pretlow T.G., Petersen R.B., and Pretlow T.P. The identification of monoclonality in human aberrant crypt foci. Cancer Res. 59 (1999) 63-66
20. Roncucci L., Pedroni M., Vaccina F., Benatti P., Marzona L., and De Pol A. Aberrant crypt foci in colorectal carcinogenesis. Cell and crypt dynamics. Cell Prolif. 33 (2000) 1-18
21. Roncucci L., Pedroni M., Fante R., Di Gregorio C., and Ponz de Leon M. Cell kinetic evaluation of human colonic aberrant crypts. Cancer Res. 53 (1993) 3726-3729
22. Siu I.-M., Pretlow T.G., Amini S., and Pretlow T.P. Identification of dysplasia in human colonic aberrant crypt foci. Am. J. Pathol. 150 (1997) 1805-1813
23. Di Gregorio C., Losi L., Fante R., Modica S., Ghidoni M., Pedroni M., et al. Histology of aberrant crypt foci in the human colon. Histopathology 30 (1997) 328-334
24. Vaccina F., Scorcioni F., Pedroni M., Tamassia M.G., Ponz de Leon M., De Pol A., et al. Scanning electron microscopy of aberrant crypt foci in human colorectal mucosa. Anticancer Res. 18 (1998) 3451-3456
25. Chan T.A., Wang Z., Dang L.H., Vogelstein B., and Kinzler K.W. Targeted inactivation of CTNNB1 reveals unexpected effects of β-catenin mutation. Proc. Natl Acad. Sci. USA 99 (1999) 8265-8270
26. Neufeld K.L., Nix D.A., Bogerd H., Kang Y., Beckerle M.C., Cullen B.R., and White R.L. Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proc. Natl Acad. Sci. USA 97 (2000) 12085-12090
27. Xing P.H., Pretlow T.G., Rao J.S., and Pretlow T.P. β-catenin expression is altered in human colonic aberrant crypt foci. Cancer Res. 61 (2001) 8085-8088
28. Furihata T., Kawamata H., Kubota K., and Fujimori T. Evaluation of the malignant potential of aberrant crypt foci by immunohistochemical staining for β-catenin in inflammation-induced rat colon carcinogenesis. Int. J. Mol. Med. 9 (2002) 353-358
29. Femia A.P., Bendinelli B., Giannini A., Salvadori M., Pinzani P., Dolara P., and Caderni G. Mucin-depleted foci have β-catenin gene mutations, altered expression of its protein, and are dose- and time-dependent in the colon of 1,2-dimethylhydrazine-treated rats. Int. J. Cancer 116 (2005) 9-15
30. Samowitz W.S., Powers M.D., Spirio L.N., Nollet F., van Roy F., and Slattery M.L. β-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas. Cancer Res. 59 (1999) 1442-1444