Immunomodulatory effects of feed-borne fusarium mycotoxins in chickens infected with coccidia

Experimental Biology and Medicine

Volumn 233, Issue 11, 2008, Pages 1411-1420

  Girgis, George N ^a   Sharif, Shayan ^a   Barta, John R ^a   Boermans, Herman J ^a   Smith, Trevor K ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

Chickens; Coccidia; Fusarium mycotoxins; Immunomodulation

Indexed keywords

15 ACETYL DEOXYNIVALENOL; GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MYCOTOXIN; POLYMERIC GLUCOMANNAN MYCOTOXIN ADSORBENT; UNCLASSIFIED DRUG; VOMITOXIN; ZERANOL; IMMUNOGLOBULIN;

ANIMAL EXPERIMENT; ARTICLE; BIRD; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL POPULATION; CHICKEN; COCCIDIAL INFECTION; COCCIDIOSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DIET; FEMALE; FOOD CONTAMINATION; FUSARIUM; GENE EXPRESSION; GRAIN; IMMUNOMODULATION; INOCULATION; MONONUCLEAR CELL; NONHUMAN; OOCYST; TONSIL; UPREGULATION; ANIMAL; ANIMAL DISEASE; ANIMAL FOOD; BLOOD; CHEMISTRY; DRUG EFFECT; EIMERIA; GENETICS; IMMUNITY; IMMUNOLOGY; ISOLATION AND PURIFICATION; LEUKOCYTE COUNT; LYMPHOCYTE; MICROBIOLOGY; PARASITOLOGY; WEIGHT GAIN;

AVES; COCCIDIA; EIMERIA ACERVULINA; FUSARIUM; GALLUS GALLUS;

ANIMAL FEED; ANIMALS; CHICKENS; COCCIDIOSIS; EIMERIA; FEMALE; FUSARIUM; GENE EXPRESSION; IMMUNITY; IMMUNOGLOBULINS; LEUKOCYTE COUNT; LYMPHOCYTES; MYCOTOXINS; OOCYSTS; WEIGHT GAIN;

EID: 58249089683     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.3181/0805-RM-173     Document Type: Article

References (46)

1. Abdul-Careem M, Hunter B, Sarson A, Mayameei A, Zhou H, Sharif S. Marek's disease virus-induced transient paralysis is associated with cytokine gene expression in the nervous system. Viral Immunol 19: 167-176, 2006.
2. Becker CE, O'Neill LAJ. Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs. Semin Immunopathol 29:239-248, 2007.
3. Beckmann L, Simon O, Vahjen W. Isolation and identification of mixed linked beta-glucan degrading bacteria in the intestine of broiler chickens and partial characterization of respective 1,3-1,4-beta- glucanase activities. J Basic Microbiol 46:75-85, 2006.
4. Berthiller F, Asta CD, Schuhmacher R, Lemmens M, Adam G, Krska R. Masked mycotoxins: determination of a deoxynivalenol glucoside in artificially and naturally contaminated wheat by liquid chromatog-raphy-tandem mass spectrometry. J Agric Food Chem 53:3421-3425, 2005.
5. Bondy G, Pestka JJ. Immunomodulation by fungal toxins. J Toxicol Environ Health B 3:109-143, 2000.
6. Canadian Council on Animal Care. Guide to the care and use of experimental animals. Vol. 1. Ottawa, ON, Canada: CCAC, 1993.
7. Chowdhury SR, Smith TK, Boermans HJ, Woodward B. Effects of feed-borne Fusarium mycotoxins on hematology and immunology of laying hens. Poult Sci 84:1841-1850, 2005.
8. Dänicke S, Valenta H, Mattes S. On the interactions between Fusarium toxin-contaminated wheat and non-starch polysaccharide hydrolyzing enzymes in diets of broilers on performance, intestinal viscosity, and carryover of deoxynivalenol. Poult Sci 85:291-298, 2007.
9. Davis ND, Dickens JW, Freie RL, Hamilton PB, Shotwell OL, Wyllie TD, Fulkerson JF. Protocols for surveys, sampling, post-collection handling, and analysis of grain samples involved in mycotoxin problems. J Assoc Off Anal Chem 63:95-102, 1980.
10. Desjardins AE. Natural occurrence of trichothecenes. In: Desjardins AE, Ed. Fusarium Mycotoxins Chemistry, Genetics and Biology. Minnesota: APS Press, pp23-33, 2006.
11. Desjardins AE. Mechanism of action of trichothecenes. In: Desjardins AE, Ed. Fusarium Mycotoxins Chemistry, Genetics and Biology. Minnesota: APS, pp53-54, 2006.
12. Ding X, Lillehoj HS, Quiroz MA, Bevensee E, Lillehoj EP. Protective immunity against Eimeria acervulina following in ovo immunization with recombinant subunit vaccine and cytokine genes. Infect Immun 72:6939-6944, 2004.
13. Eriksen GS, Pettersson H. Toxicological evaluation of trichothecenes in animal feed. Anim Feed Sci Technol 114:205-239, 2004.
14. Garside P. A role for IL-18 in intestinal inflammation? Gut 48:6-9, 2001.
15. Göbel TW, Schneider K, Schaerer B, Mejri I, Puehler F, Weigend S, Staeheli P, Kaspers B. IL-18 stimulates the proliferation and IFN-γ release of CD4+ T cells in the chicken: conservation of a Th1-like system in a non-mammalian species. J Immunol 171:1809-1815, 2003.
16. Holt PS, Corrier DE, DeLoach JR. Suppressive and enhancing effect of T-2 toxin on murine lymphocyte activation and interleukin 2 production. Immunopharmacol Immunotoxicol 10:365-385, 1988.
17. Hong YH, Lillehoj HS, Lee SH, Dalloul LA, Lillehoj EP. Analysis of chicken cytokine and chemokine gene expression following Eimeria acervulina and Eimeria tenella infections. Vet Immunol Immunopathol 114:209-223, 2006.
18. Johnson J, Reid WM. Anticoccidial drugs: lesion scoring techniques in battery and floor-pen experiments with chickens. Exp Parasitol 28:30-36, 1970.
19. Kabak B, Dobson AD, Var I. Strategies to prevent mycotoxin contamination of food and animal feed: a review. Crit Rev Food Sci Nutr 46:593-619, 2006.
20. Laurent F, Mancassola R, Lacroix S, Menezes R, Naciri M. Analysis of chicken mucosal immune response to Eimeria tenella and Eimeria maxima infection by quantitative reverse transcription-PCR. Infect Immun 69:2527-2534, 2001.
21. Lewis JG. Introduction to the mononuclear phagocyte system. In: Burleson GR, Dean JH, Munson AE, Eds. Methods in Immunotoxicology. New York: Wiley-Liss, p3, 1995.
22. Li M, Cuff CF, Pestka JJ. Modulation of murine host response to enteric reovirus infection by the trichothecene deoxynivalenol. Toxicol Sci 87:134-145, 2005.
23. Li M, Cuff CF, Pestka JJ. T-2 toxin impairment of enteric reovirus clearance in the mouse associated with suppressed immunoglobulin and IFN-γ response. Toxicol Appl Pharmacol 214:318-325, 2006.
24. Lillehoj HS, Trout JM. Avian gut-associated lymphoid tissues and intestinal immune responses to Eimeria parasites. Clin Microbiol Rev 9:349-360, 1996.
25. Min W, Lillehoj HS, Burnside J, Weining KC, Staeheli P, Zhu JJ. Adjuvant effects of IL-1β, IL-2, IL-8, IL-15, IFN-α, IFN-γ, TGF-β4 and lymphoactin on DNA vaccination against Eimeria acervulina. Vaccine 20:267-274, 2002.
26. Moore KW, Malefyt RW, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19:683-765, 2001.
27. NRC. Nutrient requirements of poultry. Washignton DC: Natl Acad Sci, 1994.
28. Oswald IP, Marin DE, Bouhet S, Pinton P, Taranu I, Accensi F. Immunotoxicological risk of mycotoxins for domestic animals. Food Add Contam 22:354-360, 2005.
29. Pestka JJ. Deoxynivalenol-induced IgA production and IgA nephropathy-aberrant mucosal immune response with systemic repercussions. Toxicol Lett 140:287-295, 2003.
30. Pestka JJ, Smolinski AT. Deoxynivalenol: toxicology and potential effects on humans. J Toxicol Environ Health B Crit Rev 8:39-69, 2005.
31. Pestka JJ, Zhou H, Moon Y, Chung YJ. Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unraveling a paradox. Toxicol Lett 153:61-73, 2004.
32. Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30:e36, 2002.
33. Puehler F, Göbel T, Breyer U, Ohnemus A, Staeheli P, Kaspers B. A sensitive bioassay for chicken interleukin-18 based on the inducible release of preformed interferon-γ. J Immunol Methods 274:229-232, 2003.
34. Rasooly L, Pestka JJ. Vomitoxin-induced dysregulation of serum IgA, IgM and IgG reactive with gut bacterial and self antigens. Food Chem Toxicol 30:499-504, 1992.
35. Raymond SL, Smith TK, Swamy HVLN. Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on feed intake, serum chemistry, and hematology of horses, and the efficacy of a polymeric glucomannan mycotoxin adsorbent. J Anim Sci 81:2123-2130, 2003.
36. Schneweis I, Meyer K, Engelhardt G, Bauer J. Occurrence of zearalenone-4-β-D-glucopyranoside in wheat. J Agric Food Chem 50: 1736-1738, 2002.
37. Sivakumar PV, Westrich GM, Kanaly S, Garka K, Born TL, Derry JMJ, Viney JL. Interleukin 18 is a primary mediator of the inflammation associated with dextran sulfate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage. Gut 50:812-820, 2002.
38. Song KD, Lillehoj HS, Choi KD, Zarlenga D, Han JY. Expression and functional characterization of recombinant chicken interferon-gamma. Vet Immunol Immunopathol 58:321-333, 1997.
39. Strober W. Trypan blue exclusion test for cell viability. In: Coligan JE, Kruisbeek AM, Marguiles DH, Shevach EM, Strober W, Eds. Current Protocols in Immunology. New York: Wiley, ppA.3.3-4, 1991.
40. Swamy HVLN, Smith TK, Cotter PF, Boermans HJ, Sefton AE. Effects of feeding blends of grains naturally contaminated with Fusarium mycotoxins on production and metabolism in broilers. Poult Sci 81: 966-975, 2002.
41. Swamy HVLN, Smith TK, Karrow NA, Boermans HJ. Effects of feeding blends of grains naturally contaminated with Fusarium mycotoxins on growth and immunological parameters of broiler chickens. Poult Sci 83:533-543, 2004.
42. Yan D, Zhou H, Brooks KH, Pestka JJ. Potential role for IL-5 and IL-6 in enhanced IgA secretion by Peyer's patch cells isolated from mice acutely exposed to vomitoxin. Toxicol 122:145-158, 1997.
43. Yegani M, Smith TK, Leeson S, Boermans HJ. Effects of feeding grains naturally contaminated with Fusarium mycotoxins on performance and metabolism of broiler breeders. Poult Sci 85:1541-1549, 2006.
44. Yun CH, Lillehoj HS, Choi KD. Eimeria tenella infection induces local gamma interferon production and intestinal lymphocytes subpopulation changes. Infect Immun 68:1282-1288, 2000.
45. Zeković DB, Kwiatkowski S, Vrvić MM, Jakovljević D, Moran CA. Natural and modified (1→3)-β-D-glucans in health promotion and disease alleviation. Crit Rev Biotechnol 25:205-230, 2005.
46. Zubiaga AM, Munoz E, Huber BT. Superinduction of IL-2 gene transcription in the presence of cycloheximide. J Immunol 146:3857-3863, 1991.