Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1α mRNA 3′-UTR and modulate HIF-1α protein expression

Biochemical Journal

Volumn 417, Issue 1, 2009, Pages 235-246

  Hägele, Sonja ^a   Kühn, Uwe ^b   Böning, Melanie ^a   Katschinski, Dörthe M ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Hypoxia inducible factor (HIF); Insulin; Oxygen; Polyadenylation; Translation

Indexed keywords

ELEMENT-BINDING PROTEINS; GROWTH FACTOR; HOMOEOSTASIS; HYPOXIA-INDUCIBLE FACTOR (HIF); HYPOXIA-INDUCIBLE FACTORS; MASTER REGULATORS; NEUROBLASTOMA; OVER-EXPRESSION; POLYADENYLATION; PROTEIN EXPRESSIONS; PROTEIN LEVEL; PROTEIN STABILITY; REPORTER GENE; SHORT INTERFERING RNA; TRANSLATION; UNTRANSLATED REGIONS; XENOPUS OOCYTE;

INSULIN; MAMMALS; OXYGEN;

WELL STIMULATION;

CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN 1; CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INSULIN; MESSENGER RNA; NUCLEIC ACID BINDING PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CARBON MONOXIDE; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; CPEB1 PROTEIN, MOUSE; CPEB2 PROTEIN, MOUSE; HIF1A PROTEIN, MOUSE; LUCIFERASE; RNA BINDING PROTEIN; TRANSCRIPTION FACTOR;

3' UNTRANSLATED REGION; ANIMAL TISSUE; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REPORTER GENE; XENOPUS; ANIMAL; BIOLOGICAL MODEL; DRUG EFFECT; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GENETICS; HELA CELL; METABOLISM; OOCYTE; PHYSIOLOGY; PROTEIN BINDING; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

MAMMALIA;

3' UNTRANSLATED REGIONS; ANIMALS; CARBON MONOXIDE; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUCIFERASES; MICE; MODELS, BIOLOGICAL; MRNA CLEAVAGE AND POLYADENYLATION FACTORS; OOCYTES; POLYADENYLATION; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS; XENOPUS;

EID: 58249085308     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20081353     Document Type: Article

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