TRPM2 variants and bipolar disorder risk: Confirmation in a family-based association study

Bipolar Disorders

Volumn 11, Issue 1, 2009, Pages 1-10

  Xu, Chun ^a   Li, Peter P ^a,b,c   Cooke, Robert G ^a,c   Parikh, Sagar V ^a,c   Wang, Ke Sheng ^d   Kennedy, James L ^a,c,e   Warsh, Jerry J ^a,b,c,e  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b Department of Pharmacology ^*  (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

Bipolar disorder; Case control design; Family study design; Intracellular calcium homeostasis; SNP; TRPM2

Indexed keywords

CLUSTERIN;

ADOLESCENT; ADULT; ARTICLE; BIPOLAR DISORDER; CASE CONTROL STUDY; CONFOUNDING VARIABLE; CONTROLLED STUDY; EXON; FAMILY STUDY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PATHOGENESIS; PEDIGREE; POPULATION STRUCTURE; PRIORITY JOURNAL; PROTEIN FUNCTION; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; BIPOLAR DISORDER; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; EXONS; FAMILY HEALTH; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK; TRPM CATION CHANNELS; YOUNG ADULT;

EID: 58149529713     PISSN: 13985647     EISSN: 13995618     Source Type: Journal    
DOI: 10.1111/j.1399-5618.2008.00655.x     Document Type: Article

References (48)

1. Hayden EP, Nurnberger JI Jr. Molecular genetics of bipolar disorder. Genes Brain Behav 2006; 5: 85-95.
2. The Wellcome Trust Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447: 661-678.
3. Warsh JJ, Andreopoulos S, Li PP. Role of Intracellular calcium signaling in the pathophysiology and pharmacotherapy of bipolar disorder: Current status. Clinical Neuroscience Research 2004; 4: 201-213.
4. 2+ permeable cation channels: From gene to biological function. Cell Calcium 2003; 33: 519-531.
5. Miller BA. The role of TRP channels in oxidative stress-induced cell death. Journal of Membrane Biology 2006; 209: 1-11.
6. Xu C, Macciardi F, Li PP et al. Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 2006; 141: 36-43.
7. Yoon IS, Li PP, Siu KP et al. Altered TRPC7 gene expression in bipolar disorder. Biol Psychiatry 2001; 50: 620-626.
8. McQuillin A, Bass NJ, Kalsi G et al. Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3. Mol Psychiatry 2006; 11: 134-142.
9. Roche S, Cassidy F, Zhao C et al. Candidate gene analysis of 21q22: Support for S100B as a susceptibility gene for bipolar affective disorder with psychosis. Am J Med Genet B Neuropsychiatr Genet 2007; 144: 1094-1096.
10. Marchini J, Cardon LR, Phillips MS, Donnelly P. The effects of human population structure on large genetic association studies. Nat Genet 2004; 36: 512-517.
11. Wehage E, Eisfeld J, Heiner I et al. Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose. J Biol Chem 2002; 277: 23150-23156.
12. Frey BN, Martins MR, Petronilho FC et al. Increased oxidative stress after repeated amphetamine exposure: Possible relevance as a model of mania. Bipolar Disord 2006; 8: 275-280.
13. So J, Warsh JJ, Li PP. Impaired endoplasmic reticulum stress response in B-lymphoblasts from patients with bipolar-I disorder. Biol Psychiatry 2007; 62: 141-147.
14. Mundo E, Tharmalingham S, Neves-Pereira M et al. Evidence that the N-methyl-D-aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder. Mol Psychiatry 2003; 8: 241-245.
15. First M, Spitzer R, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders-Patient Edition (SCID-I/P) Version 2.0. New York, N.Y.: Biometrics Research Department, New York Psychiatric Institute, 1995.
16. Dalton EJ, Cate-Carter TD, Mundo E, Parikh SV, Kennedy JL. Suicide risk in bipolar patients: The role of co-morbid substance use disorders. Bipolar Disord 2003; 5: 58-61.
17. First M, Spitzer R, Gibbon M, Willians JBW. Structured Clinical Interview for DSM-IV Axis I Disorders - Nonpatient Edition (SCID-I/NP), Version 2.0. New York, N.Y.: Biometrics Research Department, New York Psychiatric Institute, 1995.
18. Lahiri DK, Nurnberger JI Jr. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res 1991; 19: 5444.
19. Laird NM, Horvath S, Xu X. Implementing a unified approach to family-based tests of association. Genet Epidemiol 2000; 19(suppl 1): S36-S42.
20. Dudbridge F. UNPHASED user guide. Technical Report 2006/5. Cambridge, UK: MRC Biostatistics Unit, 2006.
21. Clayton D. A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. Am J Hum Genet 1999; 65: 1170-1177.
22. Lange C, DeMeo D, Silverman EK, Weiss ST, Laird NM. PBAT tools for family-based association studies. Am J Hum Genet 2004; 74: 367-369.
23. Lange C, Blacker D, Laird NM. Family-based association tests for survival and times-to-onset analysis. Stat Med 2004; 23: 179-189.
24. Leboyer M, Henry C, Paillere-Martinot ML, Bellivier F. Age at onset in bipolar affective disorders: A review. Bipolar Disord 2005; 7: 111-118.
25. Bellivier F, Golmard JL, Rietschel M et al. Age at onset in bipolar I affective disorder: Further evidence for three subgroups. Am J Psychiatry 2003; 160: 999-1001.
26. McInnis MG, Lan TH, Willour VL et al. Genome-wide scan of bipolar disorder in 65 pedigrees: Supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12. Mol Psychiatry 2003; 8: 288-298.
27. Maeda K, Nwulia E, Chang J et al. Differential Expression of Disrupted-in-Schizophrenia (DISC1) in Bipolar Disorder. Biol Psychiatry 2006; 60: 929-935.
28. Schulze TG, Buervenich S, Badner JA et al. Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees. Biol Psychiatry 2004; 56: 18-23.
29. Underwood SL, Christoforou A, Thomson PA et al. Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia. Mol Psychiatry 2006; 11: 384-394.
30. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG. Replication validity of genetic association studies. Nat Genet 2001; 29: 306-309.
31. MacQueen GM, Young LT. Bipolar II disorder: Symptoms, course, and response to treatment. Psychiatr Serv 2001; 52: 358-361.
32. MacQueen GM, Hajek T, Alda M. The phenotypes of bipolar disorder: relevance for genetic investigations. Mol Psychiatry 2005; 10: 811-826.
33. Otani K, Ujike H, Tanaka Y et al. The GABA type A receptor alpha5 subunit gene is associated with bipolar I disorder. Neurosci Lett 2005; 381: 108-113.
34. Kuratomi G, Iwamoto K, Bundo M et al. Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins. Mol Psychiatry 2008; 13: 429-441.
35. Hasler G, Drevets WC, Gould TD, Gottesman II, Manji HK. Toward constructing an endophenotype strategy for bipolar disorders. Biol Psychiatry 2006; 60: 93-105.
36. Craddock N, Forty L. Genetics of affective (mood) disorders. Eur J Hum Genet 2006; 14: 660-668.
37. Schulze TGM, Hedeker DP, Zandi PP, Rietschel MM, McMahon FJM. What Is familial about familial bipolar disorder?: Resemblance among relatives across a broad spectrum of phenotypic characteristics. Arch Gen Psychiatry 2006; 63: 1368-1376.
38. Zammit S, Lewis G, Thapar A et al. Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia. J Psychiatr Res 2006; 40: 622-626.
39. Schulze TG, Muller DJ, Krauss H et al. Caught in the trio trap? Potential selection bias inherent to association studies using parent-offspring trios Am J Med Genet 2001; 105: 351-353.
40. Hirschhorn JN, Daly MJ. Genome-wide association studies for common diseases and complex traits. Nat Rev Genet 2005; 6: 95-108.
41. Lin PI, Vance JM, Pericak-Vance MA, Martin ER. No gene is an island: The flip-flop phenomenon. Am J Hum Genet 2007; 80: 531-538.
42. Gu S, Pakstis AJ, Li H et al. Significant variation in haplotype block structure but conservation in tagSNP patterns among global populations. Eur J Hum Genet 2007; 15: 302-312.
43. Potash JB, DePaulo JR Jr. Searching high and low: A review of the genetics of bipolar disorder. Bipolar Disord 2000; 2: 8-26.
44. Gimelbrant A, Hutchinson JN, Thompson BR, Chess A. Widespread monoallelic expression on human autosomes. Science 2007; 318: 1136-1140.
45. Knight JC. Regulatory polymorphisms underlying complex disease traits. J Mol Med 2005; 83: 97-109.
46. Hunter DJ. Gene-environment interactions in human diseases. Nat Rev Genet 2005; 6: 287-298.
47. Hemminki K, Lorenzo BJ, Forsti A. The balance between heritable and environmental aetiology of human disease. Nat Rev Genet 2006; 7: 958-965.
48. Chanock SJ, Manolio T, Boehnke M et al. Replicating genotype-phenotype associations. Nature 2007; 447: 655-660.