Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia

Molecular Psychiatry

Volumn 11, Issue 4, 2006, Pages 384-394

  Underwood, S L ^a   Christoforou, A ^a,b   Thomson, P A ^a   Wray, N R ^a   Tenesa, A ^b   Whittaker, J ^c   Adams, R A ^a   Le Hellard, S ^a   Morris, S W ^a   Blackwood, D H R ^a   Muir, W J ^a   Porteous, D J ^a   Evans, K L ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Association study; Bipolar disorder; G protein coupled receptors; Linkage disequilibrium; Schizophrenia

Indexed keywords

G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 78; UNCLASSIFIED DRUG;

ARTICLE; BIPOLAR DISORDER; CHROMOSOME 4P; CONTROLLED STUDY; FAMILY STUDY; FEMALE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC CODE; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOTYPE; GPR78 GENE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SCHIZOPHRENIA; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM;

BIPOLAR DISORDER; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 4; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; LOD SCORE; LOGISTIC MODELS; MALE; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; SCHIZOPHRENIA; SEX FACTORS;

EID: 33645505400     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/sj.mp.4001786     Document Type: Article

References (55)

1. Craddock N, Khodel V, Van Eerdewegh P, Reich T. Mathematical limits of multilocus models: the genetic transmission of bipolar disorder. Am J Hum Genet 1995; 57: 690-702.
2. Berry N, Jobanputra V, Pal H. Molecular genetics of schizophrenia: a critical review. J Psychiatry Neurosci 2003; 28: 415-429.
3. Tsuang MT, Taylor L, Faraone SV. An overview of the genetics of psychotic mood disorders. J Psychiatr Res 2004; 38: 3-15.
4. Blackwood DH, He L, Morris SW, McLean A, Whitton C, Thomson M et al. A locus for bipolar affective disorder on chromosome 4p. Nat Genet 1996; 12: 427-430.
5. Le Hellard S, Lee AJ, Underwood S, Thomson PA, Morris SW, Torrance HS et al. Haplotype analysis and a novel allele sharing method refines a chromosome 4p locus linked to bipolar disorder and schizophrenia. 2005 (submitted).
6. Asherson P, Mant R, Williams N, Cardno A, Jones L, Murphy K et al. A study of chromosome 4p markers and dopamine D5 receptor gene in schizophrenia and bipolar disorder. Mol Psychiatry 1998; 3: 310-320.
7. Ewald H, Degn B, Mors O, Kruse TA. Support for the possible locus on chromosome 4p16 for bipolar affective disorder. Mol Psychiatry 1998; 3: 442-448.
8. Detera-Wadleigh SD, Badner JA, Berrettini WH, Yoshikawa T, Goldin LR, Turner G et al. A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc Natl Acad Sci USA 1999; 96: 5604-5609.
9. Williams NM, Rees MI, Holmans P, Norton N, Cardno AG, Jones LA et al. A two-stage genome scan for schizophrenia susceptibility genes in 196 affected sibling pairs. Hum Mol Genet 1999; 8: 1729-1739.
10. Lerer B, Segman RH, Hamdan A, Kanyas K, Karni O, Kohn Y et al. Genome scan of Arab Israeli families maps a schizophrenia susceptibility gene to chromosome 6q23 and supports a locus at chromosome 10q24. Mol Psychiatry 2003; 8: 488-498.
11. Als TD, Dahl HA, Flint TJ, Wang AG, Vang M, Mors O et al. Possible evidence for a common risk locus for bipolar affective disorder and schizophrenia on chromosome 4p16 in patients from the Faroe Islands. Mol Psychiatry 2004; 9: 93-98.
12. Evans KL, Le Hellard S, Morris SW, Lawson D, Whitton C, Semple CA et al. A 6.9 Mb high-resolution BAC/PAC contig of human 4p153-p161 a candidate region for bipolar affective disorder. Genomics 2001; 71: 315-323.
13. Gould TD, Manji HK. Signaling networks in the pathophysiology and treatment of mood disorders. J Psychosom Res 2002; 53: 687-697.
14. Gonzalez-Maeso J, Rodriguez-Puertas R, Meana JJ, Garcia-Sevilla JA, Guimon J. Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)-adrenoceptors. Mol Psychiatry 2002; 7: 755-767.
15. Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A et al. Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor. Mol Psychiatry 2005; 10: 470-478.
16. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O et al. Discovery and mapping of ten novel G protein-coupled receptor genes. Gene 2001; 275: 83-91.
17. Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR et al. Cloning and characterization of additional members of the G protein-coupled receptor family. Biochim Biophys Acta 2000; 1490: 311-323.
18. Herman JP, Prewitt CM, Cullinan WE. Neuronal circuit regulation of the hypothalamo-pituitary-adrenocortical stress axis. Crit Rev Neurobiol 1996; 10: 371-394.
19. Rybakowski JK, Twardowska K. The dexamethasone/corticotropin-releasing hormone test in depression in bipolar and unipolar affective illness. J Psychiatr Res 1999; 33: 363-370.
20. Pariante CM, Miller AH. Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol Psychiatry 2001; 49: 391-404.
21. Altamura AC, Boin F, Maes M. HPA axis and cytokines dysregulation in schizophrenia: potential implications for the antipsychotic treatment. Eur Neuropsychopharmacol 1999; 10: 1-4.
22. Weinstock M. Does prenatal stress impair coping and regulation of hypothalamic-pituitary-adrenal axis? Neurosci Biobehav Rev 1997; 21: 1-10.
23. Bromet EJ, Fennig S. Epidemiology and natural history of schizophrenia. Biol Psychiatry 1999; 46: 871-881.
24. Endicott J, Spitzer RL. A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 1978; 35: 837-844.
25. Association AP. Diagnostic and Statistical Manual of Mental Disorders 4th edn. (DSM-IV). APA: Washington, DC, 1994.
26. World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. WHO: Geneva, 1992.
27. Risch NJ. Searching for genetic determinants in the new millennium. Nature 2000; 405: 847-856.
28. Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000; 132: 365-386.
29. Gordon D, Abajian C, Green P. Consed: a graphical tool for sequence finishing. Genome Res 1998; 8: 195-202.
30. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265.
31. 2 measure of linkage disequilibrium: impact on design and interpretation of association studies. Twin Res Hum Genet 2005; 8: 87-94.
32. Wall JD, Pritchard JK. Haplotype blocks and linkage disequilibrium in the human genome. Nat Rev Genet 2003; 4: 587-597.
33. Berrettini W. Evidence for shared susceptibility in bipolar disorder and schizophrenia. Am J Med Genet C 2003; 123: 59-64.
34. Craddock N, O'Donovan MC, Owen MJ. The genetics of schizophrenia and bipolar disorder: dissecting psychosis. J Med Genet 2005; 42: 193-204.
35. Holden C. Sex and the suffering brain. Science 2005; 308: 1574.
36. Zubenko GS, Hughes III HB, Stiffler JS, Brechbiel A, Zubenko WN, Maher BS et al. Sequence variations in CREB1 cosegregate with depressive disorders in women. Mol Psychiatry 2003; 8: 611-618.
37. Kirkwood BR, Sterne JAC. Essential Medical Statistics, 2nd edn. Blackwell Science Ltd: Malden, MA, 2003.
38. Cordell HJ, Clayton DG. A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes. Am J Hum Genet 2002; 70: 124-141.
39. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 2003; 25: 115-121.
40. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. Basic local alignment search tool. J Mol Biol 1990; 215: 403-410.
41. Ng PC, Henikoff S. SIFT: predicting amino acid changes that affect protein function. Nucleic Acids Res 2003; 31: 3812-3814.
42. Cserzo M, Eisenhaber F, Eisenhaber B, Simon I. On filtering false positive transmembrane protein predictions. Protein Eng 2002; 15: 745-752.
43. Hulo N, Sigrist CJ, Le Saux V, Langendijk-Genevaux PS, Bordoli L, Gattiker A et al. Recent improvements to the PROSITE database. Nucleic Acids Res 2004; 32: D134-D137.
44. Blom N, Gammeltoft S, Brunak S. Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J Mol Biol 1999; 294: 1351-1362.
45. Blanchette M, Kent WJ, Riemer C, Elnitski L, Smit AF, Roskin KM et al. Aligning multiple genomic sequences with the threaded blockset aligner. Genome Res 2004; 14: 708-715.
46. Siepel A, Haussler D. Combining phylogenetic and hidden Markov models in biosequence analysis. J Comput Biol 2004; 11: 413-428.
47. Kent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM et al. The human genome browser at UCSC. Genome Res 2002; 12: 996-1006.
48. Karolchik D, Baertsch R, Diekhans M, Furey TS, Hinrichs A, Lu YT et al. The UCSC Genome Browser Database. Nucleic Acids Res 2003; 31: 51-54.
49. Kel AE, Gossling E, Reuter I, Cheremushkin E, Kel-Margoulis OV, Wingender E. MATCH: a tool for searching transcription factor binding sites in DNA sequences. Nucleic Acids Res 2003; 31: 3576-3579.
50. Wingender E, Chen X, Fricke E, Geffers R, Hehl R, Liebich I et al. The TRANSFAC system on gene expression regulation. Nucleic Acids Res 2001; 29: 281-283.
51. Consortium TIH. The international HapMap project. Nature 2003; 18: 789-796.
52. Akey J, Jin L, Xiong M. Haplotypes vs single marker linkage disequilibrium tests: what do we gain? Eur J Hum Genet 2001; 9: 291-300.
53. Jawaid A, Sham PC, Makoff AJ, Asherson PJ. Is haplotype tagging the panacea to association mapping studies? Eur J Hum Genet 2004; 12: 259-262.
54. Goring HH, Terwilliger JD, Blangero J. Large upward bias in estimation of locus-specific effects from genomewide scans. Am J Hum Genet 2001; 69: 1357-1369.
55. Wang WY, Barratt BJ, Clayton DG, Todd JA. Genome-wide association studies: theoretical and practical concerns. Nat Rev Genet 2005; 6: 109-118.