Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia

Journal of Psychiatric Research

Volumn 40, Issue 7, 2006, Pages 622-626

  Zammit, Stanley ^a   Lewis, Glyn ^b   Thapar, Anita ^a   Owen, Richard ^a   Jones, Gaynor ^a   Jones, Susan ^a   Sanders, Rob ^a   Milham, Charis ^a   Mahdi, Ameera ^a   O'Donovan, Michael C ^a   Owen, Michael J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Bias; Epidemiology; Genetics; Phenotype; Schizophrenia; Trios

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CHILD; DISEASE ASSOCIATION; GENETIC ASSOCIATION; GENETIC DIFFERENCE; GENETIC HETEROGENEITY; GENETIC RISK; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; PARENT; PHENOTYPE; PRIORITY JOURNAL; SCHIZOPHRENIA;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; PSYCHIATRIC STATUS RATING SCALES; RISK FACTORS; SCHIZOPHRENIA; VARIATION (GENETICS);

EID: 33748302073     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2005.05.006     Document Type: Article

References (11)

1. Bruun T.G., and Ewald H. Selection bias of susceptibility genes possible when using parent-offspring trios in genetic association studies. Molecular Psychiatry 4 (1999) 415-416
2. Curtis D., and Sham P.C. A note on the application of the transmission disequilibrium test when a parent is missing. American Journal of Human Genetics 56 (1995) 811-812
3. Endicott J., Spitzer R.L., Fleiss J.L., and Cohen J. The global assessment scale. A procedure for measuring overall severity of psychiatric disturbance. Archives of General Psychiatry 33 (1976) 766-771
4. Falk C.T., and Rubinstein P. Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations. Annals of Human Genetics 51 Pt 3 (1987) 227-233
5. Malhotra A.K., Bates J.A., Jaeger J., Petrides G., Robinson D.G., Bilder R.M., et al. No evidence for phenotypic variation between probands in case-control versus family-based association studies of schizophrenia. American Journal of Medical Genetics 114 (2002) 509-511
6. McGuffin P., Farmer A., and Harvey I. A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Archives of General Psychiatry 48 (1991) 764-770
7. Risch N.J. Searching for genetic determinants in the new millenium. Nature 405 (2000) 847-856
8. Schulze T.G., Muller D.J., Krauss H., Gross M., Bauer I., Fangerau-Lefevre H., et al. Caught in the trio trap? Potential selection bias inherent to association studies using parent-offspring trios. American Journal of Medical Genetics 105 (2001) 351-353
9. Spielman R.S., and Ewens W.J. The TDT and other family-based tests for linkage disequilibrium and association. American Journal of Human Genetics 59 (1996) 983-989
10. West A., Langley K., Hamshere M.L., Kent L., Craddock N., Owen M.J., et al. Evidence to suggest biased phenotypes in children with Attention Deficit Hyperactivity Disorder from completely ascertained trios. Molecular Psychiatry 7 (2002) 962-966
11. Wing J.K., Babor T., Brugha T., Burke J., Cooper J.E., Giel R., et al. SCAN. Schedules for Clinical Assessment in Neuropsychiatry. Archives of General Psychiatry 47 (1990) 589-593